Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABAAR‐Dependent TRIM21 Modulation of Src Expression
Source abstract
Abstract
Abstract Generation of circulating tumor cells (CTCs), a key step in tumor metastasis, occurs during surgical tumor resection, often performed under general anesthesia. Propofol is the commonly used anesthetic, but its effects on CTCs and tumor metastasis remain largely unknown. Propofol effects are investigated in an experimental metastasis model by injecting tumor cells and, subsequently, low‐ or standard‐dose propofol to nude mice through tail vein. Propofol‐ or vehicle‐treated tumor cells are also injected to the mice. An in vitro tumor cell–vascular endothelial cell adhesion assay, immunofluorescence, and other methods are employed to assess how propofol affects tumor cell adhesion and extension. Propofol induces more lung tumor metastasis in mice than control. Mechanistically, propofol enhances tumor cell adhesion and extension through GABAAR to downregulate TRIM21 expression, leading to upregulation of Src, a protein associated with cell adhesion. These results demonstrate that propofol may promote tumor metastasis through GABAAR–TRIM21–Src mechanism.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Cancer, Stress, Anesthesia, and Immune Response · Cancer Cells and Metastasis · Neuropeptides and Animal Physiology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Anesthesia and Brain Research Institute Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 P. R. China
Department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 P. R. China
Division of Thoracic Surgery Department of Surgery Massachusetts General Hospital and Harvard Medical School Boston MA 02114 USA
Tongji University Cancer Center Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 P. R. China
Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital and Harvard Medical School Charlestown MA 02129 USA
Funding
National Natural Science Foundation of China · China Postdoctoral Science Foundation
References (79)
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