Pyroptosis‐Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy
Source abstract
Abstract
Abstract Pyroptosis can effectively overcome immunosuppression and reactivate antitumor immunity. However, pyroptosis initiation is challenging. First, the underlying biological mechanisms of pyroptosis are complex, and a variety of gasdermin family proteins can be targeted to induce pyroptosis. Second, other intracellular death pathways may also interfere with pyroptosis. The rationally designed gasdermin protein‐targeting biomaterials are capable of inducing pyroptosis and have the capacity to stimulate antitumor immune function in a safe and effective manner. This review provides a comprehensive overview of the design, function, and antitumor efficacy of pyroptosis‐inducing materials and the associated challenges, with a particular focus on the design options for pyroptosis‐inducing biomaterials based on the activation of different gasdermin proteins. This review offers a valuable foundation for the further development of pyroptosis‐inducing biomaterials for clinical applications.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Inflammasome and immune disorders · Histiocytic Disorders and Treatments · Toxoplasma gondii Research Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute for Advanced Research Wenzhou Medical University Wenzhou Zhejiang 325027 P. R. China
Department of Radiation and Medical Oncology Wenzhou Key Laboratory of Basic Science and Translational Research of Radiation Oncology Zhejiang Engineering Research Center for Innovation and Application of Intelligent Radiotherapy Technology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 P. R. China
The First Affiliated Hospital of Wenzhou Medical University Wenzhou Medical University Wenzhou Zhejiang 325027 P. R. China
Department of Oncology Xijing Hospital of Air Force Military Medical University Xi'an Shaanxi 710032 P. R. China
The First Hospital of Xi'an Jiaotong University Xi'an Shanxi 710061 P. R. China
Funding
National Natural Science Foundation of China · Wenzhou Medical University · Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
References (100+)
Show source-provided references
1. 10.1038/s41577-024-01026-410.1038/s41577-024-01026-4 ↗
2. 10.1038/s41568-024-00674-x10.1038/s41568-024-00674-x ↗
3. 10.1056/NEJMoa191060710.1056/NEJMoa1910607 ↗
4. 10.1016/j.cell.2022.09.02010.1016/j.cell.2022.09.020 ↗
5. 10.1200/JCO.2020.38.15_suppl.e1929410.1200/JCO.2020.38.15_suppl.e19294 ↗
6. 10.1038/nrclinonc.2016.16810.1038/nrclinonc.2016.168 ↗
7. 10.1038/s41577-019-0228-210.1038/s41577-019-0228-2 ↗
8. 10.1038/nature1551410.1038/nature15514 ↗
9. 10.1038/s41586-020-2079-110.1038/s41586-020-2079-1 ↗
10. 10.1038/s41586-020-2071-910.1038/s41586-020-2071-9 ↗
11. 10.1126/science.aaz754810.1126/science.aaz7548 ↗
12. 10.1038/s41577-019-0269-610.1038/s41577-019-0269-6 ↗
13. 10.1038/s41565-022-01125-010.1038/s41565-022-01125-0 ↗
14. 10.1038/s41589-022-01145-w10.1038/s41589-022-01145-w ↗
15. 10.1007/s00335990067310.1007/s003359900673 ↗
16. 10.1007/s00335001013810.1007/s003350010138 ↗
17. 10.1038/250310.1038/2503 ↗
18. 10.1016/S0021-9258(17)38364-310.1016/S0021-9258(17)38364-3 ↗
19. Nakamura S. · Jpn. J. Cancer Res. · 1986 · 77 · 767
20. 10.1038/358167a010.1038/358167a0 ↗
21. 10.1002/stem.14016410.1002/stem.140164 ↗
22. 10.1128/iai.65.12.5165-5170.199710.1128/iai.65.12.5165-5170.1997 ↗
23. 10.1016/S0966-842X(00)01936-310.1016/S0966-842X(00)01936-3 ↗
24. 10.1038/nm.202810.1038/nm.2028 ↗
25. 10.1111/j.1600-065X.2012.01146.x10.1111/j.1600-065X.2012.01146.x ↗
26. 10.1084/jem.2012200610.1084/jem.20122006 ↗
27. 10.1073/pnas.101681410810.1073/pnas.1016814108 ↗
28. 10.1111/j.1462-5822.2005.00569.x10.1111/j.1462-5822.2005.00569.x ↗
29. 10.1128/IAI.71.8.4448-4455.200310.1128/IAI.71.8.4448-4455.2003 ↗
30. 10.1038/nature1554110.1038/nature15541 ↗
31. 10.1073/pnas.160776911310.1073/pnas.1607769113 ↗
32. 10.1016/j.tibs.2016.10.00410.1016/j.tibs.2016.10.004 ↗
33. 10.1038/nature1551410.1038/nature15514 ↗
34. 10.1155/2015/83480510.1155/2015/834805 ↗
35. 10.1038/ncomms1412810.1038/ncomms14128 ↗
36. 10.4049/jimmunol.190038310.4049/jimmunol.1900383 ↗
37. 10.1038/s41467-019-09397-210.1038/s41467-019-09397-2 ↗
38. 10.1038/s41577-019-0228-210.1038/s41577-019-0228-2 ↗
39. 10.1038/cr.2015.13910.1038/cr.2015.139 ↗
40. 10.1038/nature1862910.1038/nature18629 ↗
41. 10.1038/nature1859010.1038/nature18590 ↗
42. 10.15252/embj.20169469610.15252/embj.201694696 ↗
43. 10.1038/cr.2015.13910.1038/cr.2015.139 ↗
44. 10.1016/j.immuni.2015.08.01310.1016/j.immuni.2015.08.013 ↗
45. 10.1038/nature2239310.1038/nature22393 ↗
46. 10.1038/ncomms1412810.1038/ncomms14128 ↗
47. 10.1016/j.celrep.2021.10899810.1016/j.celrep.2021.108998 ↗
48. 10.1038/nature1859010.1038/nature18590 ↗
49. 10.1038/s41586-021-04384-410.1038/s41586-021-04384-4 ↗
50. 10.1080/0031302070171625010.1080/00313020701716250 ↗
51. 10.1593/tlo.0811210.1593/tlo.08112 ↗
52. 10.1038/s41586-020-2071-910.1038/s41586-020-2071-9 ↗
53. 10.1126/science.aaz754810.1126/science.aaz7548 ↗
54. 10.1111/j.1349-7006.2001.tb01076.x10.1111/j.1349-7006.2001.tb01076.x ↗
55. 10.1371/journal.pone.016642210.1371/journal.pone.0166422 ↗
56. 10.1200/JCO.2021.39.15_suppl.e1625610.1200/JCO.2021.39.15_suppl.e16256 ↗
57. 10.1038/s41556-020-0575-z10.1038/s41556-020-0575-z ↗
58. 10.1002/gcc.2063610.1002/gcc.20636 ↗
59. 10.1002/adfm.20231136210.1002/adfm.202311362 ↗
60. 10.1021/acsami.1c2280410.1021/acsami.1c22804 ↗
61. 10.1002/adma.20230948810.1002/adma.202309488 ↗
62. 10.1002/anie.20201639910.1002/anie.202016399 ↗
63. 10.1016/j.nantod.2022.10151110.1016/j.nantod.2022.101511 ↗
64. 10.1002/anie.20221098810.1002/anie.202210988 ↗
65. 10.1002/anie.20211580010.1002/anie.202115800 ↗
66. 10.1002/advs.20220291410.1002/advs.202202914 ↗
67. Chen H. · Chem. Eng. J. · 2023 · 476 · 15
68. 10.1021/acsnano.3c0500510.1021/acsnano.3c05005 ↗
69. 10.1016/j.bioactmat.2022.05.03710.1016/j.bioactmat.2022.05.037 ↗
70. 10.1002/anie.20231015810.1002/anie.202310158 ↗
71. 10.1021/jacs.2c1318910.1021/jacs.2c13189 ↗
72. 10.1002/adma.20230023210.1002/adma.202300232 ↗
73. 10.1002/advs.20230242210.1002/advs.202302422 ↗
74. Xu S. · Chem. Eng. J. · 2023 · 460 · 15
75. 10.1016/j.bioactmat.2022.07.01610.1016/j.bioactmat.2022.07.016 ↗
76. 10.1021/jacs.3c0418010.1021/jacs.3c04180 ↗
77. 10.1002/adma.20230507310.1002/adma.202305073 ↗
78. Lu Y.‐F. · Chem. Eng. J. · 2024 · 481 · 1
79. 10.1021/jacs.0c0948210.1021/jacs.0c09482 ↗
80. 10.1002/adma.20190726710.1002/adma.201907267 ↗
81. 10.1039/D0NH00674B10.1039/D0NH00674B ↗
82. 10.1021/acs.chemmater.1c0404810.1021/acs.chemmater.1c04048 ↗
83. 10.1021/acsnano.1c0949610.1021/acsnano.1c09496 ↗
84. 10.1016/j.jhazmat.2022.12909310.1016/j.jhazmat.2022.129093 ↗
85. 10.1016/j.cej.2022.13796710.1016/j.cej.2022.137967 ↗
86. 10.1002/anie.20221530710.1002/anie.202215307 ↗
87. 10.1002/anie.20230770610.1002/anie.202307706 ↗
88. 10.1002/adma.20230646910.1002/adma.202306469 ↗
89. 10.1002/adma.20230824110.1002/adma.202308241 ↗
90. 10.1016/j.cej.2023.14708510.1016/j.cej.2023.147085 ↗
91. 10.1002/adma.20220857110.1002/adma.202208571 ↗
92. 10.1002/adfm.20230094110.1002/adfm.202300941 ↗
93. 10.1002/anie.20230186610.1002/anie.202301866 ↗
94. 10.1002/anie.20231730410.1002/anie.202317304 ↗
95. 10.1002/adma.20231212410.1002/adma.202312124 ↗
96. 10.1002/adma.20230296110.1002/adma.202302961 ↗
97. 10.1002/adma.20220881710.1002/adma.202208817 ↗
98. 10.1002/advs.20230227810.1002/advs.202302278 ↗
99. 10.1038/s41467-022-34036-810.1038/s41467-022-34036-8 ↗
100. 10.1002/adma.20231006310.1002/adma.202310063 ↗