journal article·2025-05Open access

Engineering the Immune Response to Biomaterials

Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi

Advanced Science· Volume 12· Issue 19

Abstract

Abstract Biomaterials are increasingly used as implants in the body, but they often elicit tissue reactions due to the immune system recognizing them as foreign bodies. These reactions typically involve the activation of innate immunity and the initiation of an inflammatory response, which can persist as chronic inflammation, causing implant failure. To reduce these risks, various strategies have been developed to modify the material composition, surface characteristics, or mechanical properties of biomaterials. Moreover, bioactive materials have emerged as a new class of biomaterials that can induce desirable tissue responses and form a strong bond between the implant and the host tissue. In recent years, different immunomodulatory strategies have been incorporated into biomaterials as drug delivery systems. Furthermore, more advanced molecule and cell‐based immunomodulators have been developed and integrated with biomaterials. These emerging strategies will enable better control of the immune response to biomaterials and improve the function and longevity of implants and, ultimately, the outcome of biomaterial‐based therapies.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: RNA Interference and Gene Delivery · Nanoplatforms for cancer theranostics · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bioengineering P.C. Rossin College of Engineering & Applied Science Lehigh University Bethlehem PA 18015 USA

Department of Mechanical Engineering & Mechanics Lehigh University Bethlehem PA 18015 USA

Department of Nano and Chemical Engineering University of California San Diego La Jolla CA 92093 USA

Department of Chemistry Faculty of Engineering, Istanbul University‐Cerrahpaşa Istanbul, Avcılar 34320 Turkey

Department of Biomedical Engineering Erciyes University Kayseri 38039 Turkey

ERNAM – Nanotechnology Research and Application Center Erciyes University Kayseri 38039 Turkey

College of Dental Medicine Qatar University Health Qatar University P.O. Box 2713 Doha Qatar

Azrieli Research Center Centre Hospitalier Universitaire Sainte‐Justine Montreal QC H3T 1C5 Canada

Institute of Biomedical Engineering, Department of Pharmacology and Physiology Faculty of Medicine Montreal Quebec H3T 1J4 Canada

Montreal TransMedTech Institute iTMT Montreal Quebec H3T 1J4 Canada

Department of Biomedical Engineering Michigan Technological University Houghton MI 49931 USA

Health Research Institute Michigan Technological University Houghton MI 49931 USA

BioFrontiers Institute University of Colorado Boulder CO 80303 USA

Institute for Quantitative Health Science and Engineering (IQ) and Department of Biomedical Engineering (BME) Colleges of Engineering and Human Medicine Michigan State University East Lansing MI 48824 USA

Department of Bioengineering Samueli School of Engineering University of California Los Angeles Los Angeles CA 90095 USA

Funding

American Heart Association · Eesti Teadusagentuur · Foundation for the National Institutes of Health · Natural Sciences and Engineering Research Council of Canada

References (100+)

Show source-provided references
1. Health at a Glance: Asia/Pacific 2020 OECD2020.
2. 10.1038/s41590-017-0006-x10.1038/s41590-017-0006-x ↗
3. 10.3389/fimmu.2017.0196010.3389/fimmu.2017.01960 ↗
4. 10.1016/j.exger.2017.12.01510.1016/j.exger.2017.12.015 ↗
5. 10.1038/s41574-018-0059-410.1038/s41574-018-0059-4 ↗
6. 10.1002/adfm.20200722610.1002/adfm.202007226 ↗
7. 10.1016/j.mser.2014.10.00110.1016/j.mser.2014.10.001 ↗
8. 10.1016/j.smim.2007.11.00410.1016/j.smim.2007.11.004 ↗
9. 10.1097/PRS.000000000000119310.1097/PRS.0000000000001193 ↗
10. 10.1016/j.tibtech.2016.03.00910.1016/j.tibtech.2016.03.009 ↗
11. 10.1038/nm.280710.1038/nm.2807 ↗
12. 10.1016/j.bone.2016.02.02010.1016/j.bone.2016.02.020 ↗
13. B.Rolfe B.Zhang G.Campbell H.Wang J.Mooney J.Campbell Q.Huang S.Jahnke S.‐J.Le Y.‐Q.Chau The fibrotic response to implanted biomaterials: implications for tissue engineering2011.10.5772/21790 ↗
14. 10.1208/s12248-010-9175-310.1208/s12248-010-9175-3 ↗
15. 10.1002/adhm.20200215310.1002/adhm.202002153 ↗
16. 10.1089/15209150477419808910.1089/152091504774198089 ↗
17. 10.1302/0301-620X.42B1.2810.1302/0301-620X.42B1.28 ↗
18. 10.47102/annals-acadmedsg.V40N5p23710.47102/annals-acadmedsg.V40N5p237 ↗
19. 10.1016/j.bej.2022.10852210.1016/j.bej.2022.108522 ↗
20. Hench L. L. · Front Bioeng. Biotechnol. · 2015 · 3
21. 10.1039/D3BM00322A10.1039/D3BM00322A ↗
22. 10.1016/j.ceramint.2023.02.19410.1016/j.ceramint.2023.02.194 ↗
23. 10.3390/jfb1407036410.3390/jfb14070364 ↗
24. 10.3389/felec.2022.98568110.3389/felec.2022.985681 ↗
25. 10.1039/D1MA00733E10.1039/D1MA00733E ↗
26. 10.1007/s10856-015-5423-510.1007/s10856-015-5423-5 ↗
27. 10.3389/fbioe.2021.66459210.3389/fbioe.2021.664592 ↗
28. 10.1186/s40824-022-00326-x10.1186/s40824-022-00326-x ↗
29. 10.1039/D1RA02557K10.1039/D1RA02557K ↗
30. 10.1111/prd.1214810.1111/prd.12148 ↗
31. 10.1089/dia.2004.6.89810.1089/dia.2004.6.898 ↗
32. 10.1007/s10856-006-0601-010.1007/s10856-006-0601-0 ↗
33. 10.1002/jbm.b.3124310.1002/jbm.b.31243 ↗
34. 10.3390/mi1112109810.3390/mi11121098 ↗
35. 10.1007/978-3-031-21900-9_710.1007/978-3-031-21900-9_7 ↗
36. 10.3389/fbioe.2016.0007110.3389/fbioe.2016.00071 ↗
37. 10.1016/j.survophthal.2009.07.00510.1016/j.survophthal.2009.07.005 ↗
38. 10.1097/scs.0b013e31802e2a8510.1097/scs.0b013e31802e2a85 ↗
39. 10.1038/s44161-023-00232-y10.1038/s44161-023-00232-y ↗
40. 10.1016/S0735-1097(03)01056-810.1016/S0735-1097(03)01056-8 ↗
41. 10.1016/j.jvssci.2021.04.00110.1016/j.jvssci.2021.04.001 ↗
42. 10.1016/j.lab.2004.06.00210.1016/j.lab.2004.06.002 ↗
43. 10.1186/s40425-017-0257-y10.1186/s40425-017-0257-y ↗
44. 10.1007/s12026-022-09330-810.1007/s12026-022-09330-8 ↗
45. 10.2174/13816121280353076310.2174/138161212803530763 ↗
46. 10.1093/intimm/dxy05410.1093/intimm/dxy054 ↗
47. 10.1007/s40828-022-00163-410.1007/s40828-022-00163-4 ↗
48. 10.3389/fimmu.2017.0152010.3389/fimmu.2017.01520 ↗
49. 10.1016/j.jconrel.2016.01.02610.1016/j.jconrel.2016.01.026 ↗
50. 10.1186/s12929-023-00981-910.1186/s12929-023-00981-9 ↗
51. 10.1002/adhm.20200072610.1002/adhm.202000726 ↗
52. 10.1021/acsami.7b1428110.1021/acsami.7b14281 ↗
53. 10.1002/admi.20200119810.1002/admi.202001198 ↗
54. 10.1002/adfm.20190933110.1002/adfm.201909331 ↗
55. 10.1002/adma.20200296210.1002/adma.202002962 ↗
56. 10.1016/j.pmatsci.2016.04.00510.1016/j.pmatsci.2016.04.005 ↗
57. 10.1002/admi.20190057210.1002/admi.201900572 ↗
58. 10.1016/j.pmatsci.2019.10058810.1016/j.pmatsci.2019.100588 ↗
59. 10.1186/s40824-022-00314-110.1186/s40824-022-00314-1 ↗
60. 10.3390/cells1007179410.3390/cells10071794 ↗
61. 10.3390/cancers1204104910.3390/cancers12041049 ↗
62. 10.3389/fimmu.2020.0094510.3389/fimmu.2020.00945 ↗
63. 10.1016/j.ijpharm.2019.11862810.1016/j.ijpharm.2019.118628 ↗
64. 10.3389/fimmu.2021.68846010.3389/fimmu.2021.688460 ↗
65. 10.1039/D0BM00269K10.1039/D0BM00269K ↗
66. 10.1002/advs.20220510510.1002/advs.202205105 ↗
67. 10.1007/s40883-022-00279-610.1007/s40883-022-00279-6 ↗
68. 10.1016/j.actbio.2022.11.00310.1016/j.actbio.2022.11.003 ↗
69. 10.1186/s12929-018-0491-810.1186/s12929-018-0491-8 ↗
70. 10.1016/j.actbio.2017.02.01010.1016/j.actbio.2017.02.010 ↗
71. 10.1039/C7TB00157F10.1039/C7TB00157F ↗
72. 10.1021/acs.accounts.0c0033410.1021/acs.accounts.0c00334 ↗
73. 10.1002/adtp.20200012910.1002/adtp.202000129 ↗
74. 10.1021/acs.chemrev.0c0089510.1021/acs.chemrev.0c00895 ↗
75. 10.1007/s10439-013-0941-010.1007/s10439-013-0941-0 ↗
76. 10.3389/fimmu.2018.0035010.3389/fimmu.2018.00350 ↗
77. 10.3389/fimmu.2020.0104010.3389/fimmu.2020.01040 ↗
78. 10.1182/blood-2004-04-155910.1182/blood-2004-04-1559 ↗
79. 10.3389/fimmu.2021.71483210.3389/fimmu.2021.714832 ↗
80. 10.3389/fgene.2017.0016110.3389/fgene.2017.00161 ↗
81. 10.3390/cells1010266310.3390/cells10102663 ↗
82. 10.1016/j.freeradbiomed.2021.04.03210.1016/j.freeradbiomed.2021.04.032 ↗
83. 10.1097/SCS.000000000000759110.1097/SCS.0000000000007591 ↗
84. 10.1002/btm2.1044110.1002/btm2.10441 ↗
85. 10.1016/j.actbio.2021.12.02610.1016/j.actbio.2021.12.026 ↗
86. 10.1002/btm2.1038310.1002/btm2.10383 ↗
87. 10.1016/j.actbio.2018.11.03510.1016/j.actbio.2018.11.035 ↗
88. 10.1016/j.jconrel.2015.08.03810.1016/j.jconrel.2015.08.038 ↗
89. 10.1073/pnas.170361611410.1073/pnas.1703616114 ↗
90. 10.3389/fimmu.2023.126996010.3389/fimmu.2023.1269960 ↗
91. 10.1038/s41578-022-00426-z10.1038/s41578-022-00426-z ↗
92. 10.1016/j.cobme.2019.02.00410.1016/j.cobme.2019.02.004 ↗
93. 10.1002/jbm.a.3595810.1002/jbm.a.35958 ↗
94. 10.3389/fimmu.2015.0026210.3389/fimmu.2015.00262 ↗
95. 10.1039/C9MH00291J10.1039/C9MH00291J ↗
96. 10.3389/fimmu.2021.66783410.3389/fimmu.2021.667834 ↗
97. 10.1111/aji.1249310.1111/aji.12493 ↗
98. 10.1016/S0006-8993(02)03463-710.1016/S0006-8993(02)03463-7 ↗
99. 10.3390/ijms2003063610.3390/ijms20030636 ↗
100. 10.1038/s41368-022-00203-210.1038/s41368-022-00203-2 ↗