DataVXAdvanced SciencePaper
journal article·2024-11Open access

An Engineered Hierarchical Hydrogel with Immune Responsiveness and Targeted Mitochondrial Transfer to Augmented Bone Regeneration

Wenjin Cai, Shihua Mao, Ying Wang, Bicong Gao, Jiaying Zhao, Yongzheng Li, Yani Chen, Dong Zhang, Jintao Yang, Guoli Yang

Advanced Science· Volume 11· Issue 42
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Abstract

Abstract Coordinating the immune response and bioenergy metabolism in bone defect environments is essential for promoting bone regeneration. Mitochondria are important organelles that control internal balance and metabolism. Repairing dysfunctional mitochondria has been proposed as a therapeutic approach for disease intervention. Here, an engineered hierarchical hydrogel with immune responsiveness can adapt to the bone regeneration environment and mediate the targeted mitochondria transfer between cells. The continuous supply of mitochondria by macrophages can restore the mitochondrial bioenergy of bone marrow mesenchymal stem cells (BMSC). Fundamentally solving the problem of insufficient energy support of BMSCs caused by local inflammation during bone repair and regeneration. This discovery provides a new therapeutic strategy for promoting bone regeneration and repair, which has research value and practical application prospects in the treatment of various diseases caused by mitochondrial dysfunction.
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Research context

Polymers

OpenAlex topics: Mesenchymal stem cell research · Immune cells in cancer · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province Hangzhou 310000 P. R. China

Zhejiang Key Laboratory of Plastic Modification and Processing Technology College of Materials Science & Engineering Zhejiang University of Technology Hangzhou 310014 P. R. China

The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta GA 30318 USA

Funding

National Natural Science Foundation of China · National Outstanding Youth Science Fund Project of National Natural Science Foundation of China

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