journal article·2020-08Open access

Flexible Fiber Probe for Efficient Neural Stimulation and Detection

Minghui Du, Lu Huang, Jiajun Zheng, Yue Xi, Yi Dai, Weida Zhang, Wei Yan, Guangming Tao, Jianrong Qiu, Kwok‐Fai So, Chaoran Ren, Shifeng Zhou

Advanced Science· Volume 7· Issue 15

Abstract

Abstract Functional probes are a leading contender for the recognition and manipulation of nervous behavior and are characterized by substantial scientific and technological potential. Despite the recent development of functional neural probes, a flexible biocompatible probe unit that allows for long‐term simultaneous stimulation and signaling is still an important task. Here, a category of flexible tiny multimaterial fiber probes (<0.3 g) is described in which the metal electrodes are regularly embedded inside a biocompatible polymer fiber with a double‐clad optical waveguide by thermal drawing. Significantly, this arrangement enables great improvement in mechanical properties, achieves high optical transmission (>90%), and effectively minimizes the impedance (by up to one order of magnitude) of the probe. This ability allows to realize long‐term (at least 10 weeks) simultaneous optical stimulation and neural recording at the single‐cell level in behaving mice with signal‐to‐noise ratio (SNR = 30 dB) that is more than 6 times that of the benchmark probe such as an all‐polymer fiber.
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Research context

OpenAlex topics: Photoreceptor and optogenetics research · Neuroscience and Neural Engineering · Neural dynamics and brain function

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Luminescent Materials and Devices School of Materials Science and Engineering South China University of Technology Guangzhou 510640 China

Guangdong Provincial Key Laboratory of Fibre Laser Materials and Applied Techniques Guangdong Engineering Technology Research and Development Center of Special Optical Fibre Materials and Devices Guangzhou 510640 China

Guangdong‐Hongkong‐Macau Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint Laboratory Jinan University Guangzhou 510632 China

Department of Neurology and Stroke Center The First Affiliated Hospital of Jinan University Guangzhou 510632 China

Research Laboratory of Electronics Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA

School of Optical and Electronic Information Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China

College of Optical Science and Engineering State Key Laboratory of Modern Optical Instrumentation Zhejiang University Hangzhou 310027 China

Guangzhou Regenerative Medicine and Health Guangdong Laboratory Guangzhou 510530 China

Co‐innovation Center of Neuroregeneration Nantong University Nantong 226001 China

Center for Brain Science and Brain‐Inspired Intelligence Guangdong‐Hong Kong‐Macao Greater Bay Area Guangzhou 510000 China

Funding

National Outstanding Youth Science Fund Project of National Natural Science Foundation of China · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province

References (51)

Show source-provided references
1. 10.1038/nmeth.f.32410.1038/nmeth.f.324 ↗
2. 10.4103/1673-5374.21353210.4103/1673-5374.213532 ↗
3. 10.1016/j.neuron.2011.06.00410.1016/j.neuron.2011.06.004 ↗
4. 10.1146/annurev-neuro-061010-11381710.1146/annurev-neuro-061010-113817 ↗
5. 10.1016/j.cell.2010.02.03710.1016/j.cell.2010.02.037 ↗
6. 10.1038/nn.409110.1038/nn.4091 ↗
7. 10.1038/nbt.341510.1038/nbt.3415 ↗
8. 10.1073/pnas.131703311010.1073/pnas.1317033110 ↗
9. 10.1038/nbt.324510.1038/nbt.3245 ↗
10. 10.1073/pnas.131929611110.1073/pnas.1319296111 ↗
11. 10.1016/j.neuron.2017.06.01110.1016/j.neuron.2017.06.011 ↗
12. 10.1016/j.neuron.2016.12.03710.1016/j.neuron.2016.12.037 ↗
13. 10.1038/nmeth.190410.1038/nmeth.1904 ↗
14. 10.1038/ncomms130410.1038/ncomms1304 ↗
15. 10.1038/nmeth.155410.1038/nmeth.1554 ↗
16. 10.1523/JNEUROSCI.5344-13.201410.1523/JNEUROSCI.5344-13.2014 ↗
17. 10.1038/nn.342710.1038/nn.3427 ↗
18. 10.1109/TBME.1970.450273810.1109/TBME.1970.4502738 ↗
19. Campbell P. K. · Biomed. Sci. Instrum. · 1990 · 26 · 161
20. 10.1038/nature2463610.1038/nature24636 ↗
21. 10.1126/science.aav789310.1126/science.aav7893 ↗
22. 10.1038/nn.390510.1038/nn.3905 ↗
23. 10.1126/science.aan620310.1126/science.aan6203 ↗
24. 10.1038/nnano.2015.11510.1038/nnano.2015.115 ↗
25. 10.1038/nmeth.396910.1038/nmeth.3969 ↗
26. 10.1073/pnas.170550911410.1073/pnas.1705509114 ↗
27. 10.1073/pnas.171769511410.1073/pnas.1717695114 ↗
28. 10.1021/acs.nanolett.6b0267310.1021/acs.nanolett.6b02673 ↗
29. 10.1039/C4LC01321B10.1039/C4LC01321B ↗
30. 10.1016/j.neuron.2015.10.03210.1016/j.neuron.2015.10.032 ↗
31. 10.1016/j.neuron.2018.11.00210.1016/j.neuron.2018.11.002 ↗
32. 10.1038/s41583-019-0140-610.1038/s41583-019-0140-6 ↗
33. 10.1038/nbt.309310.1038/nbt.3093 ↗
34. 10.1126/sciadv.160095510.1126/sciadv.1600955 ↗
35. 10.1038/nn.409410.1038/nn.4094 ↗
36. 10.1038/natrevmats.2016.6310.1038/natrevmats.2016.63 ↗
37. 10.1038/nn.451010.1038/nn.4510 ↗
38. 10.1038/s41586-018-0390-x10.1038/s41586-018-0390-x ↗
39. 10.1088/1741-2560/2/4/00310.1088/1741-2560/2/4/003 ↗
40. 10.1039/c2lc40874k10.1039/c2lc40874k ↗
41. 10.1002/adfm.20140126610.1002/adfm.201401266 ↗
42. 10.1002/adma.20180586710.1002/adma.201805867 ↗
43. 10.1021/acsnano.5b0106010.1021/acsnano.5b01060 ↗
44. 10.1146/annurev.bioeng.10.061807.16051810.1146/annurev.bioeng.10.061807.160518 ↗
45. 10.1038/nrn317110.1038/nrn3171 ↗
46. 10.1016/j.neuron.2007.03.00510.1016/j.neuron.2007.03.005 ↗
47. 10.1038/nn152510.1038/nn1525 ↗
48. 10.1038/nmeth.180810.1038/nmeth.1808 ↗
49. 10.1016/0166-2236(89)90052-010.1016/0166-2236(89)90052-0 ↗
50. 10.1088/1741-2560/4/4/00710.1088/1741-2560/4/4/007 ↗
51. 10.1038/srep0294210.1038/srep02942 ↗