journal article·2025-08

Implantable, Biointegrated Optoelectronic Platforms with Ultrathin Encapsulation Layers as Long‐Term Neural Interfaces

Xi Wang, Lichao Ma, Yifei Lu, Zhongzheng Li, Fuying Liang, JiZhai Cui, Wei Cheng, Fan Xu, Zhijin Hou, Yongfeng Mei, Xing Sheng, Enming Song

Advanced Materials Technologies· Volume 10· Issue 16
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Abstract

Abstract With the increasing demand for advanced biomedical technologies, there is a pressing need for flexible, integrated systems capable of simultaneously detecting and stimulating biological processes with high precision and reliability. In this study, an on‐chip integrated flexible electronic system is successfully fabricated that combines both photoelectric detection and stimulation functionalities. This system integrates single‐crystal silicon nanomembrane (Si‐NM) photodiode array with micro‐all‐inorganic light‐emitting diodes (µ‐ILEDs), achieving comprehensive flexibility and complete encapsulation. The Si‐NM photodiode exhibits broad responsivity across the visible light spectrum. Observed spatial response variations enable the detector array to accurately capture spatial information, precisely determining the position and direction of the light sources. Notably, the system incorporates an ultrathin thermally grown silicon dioxide (t‐SiO2) biofluid barrier. This barrier ensures stable leakage current in the device following 120 h of immersion in 90 °C PBS solution, guaranteeing long‐term stability and reliability. Furthermore, this barrier effectively prevents the infiltration of toxic elements into surrounding tissues, ensuring the safety and biocompatibility of the implant. By leveraging advanced materials and manufacturing technologies, this system not only enhances the performance of optoelectronic devices but also expands their application scope in the biomedical field, opening new avenues for future biomedical research and clinical innovations.
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Research context

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Neuroscience and Neural Engineering · Advanced Memory and Neural Computing

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Optoelectronics & Innovation School of Future Information Department of Materials Science Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception Fudan University Shanghai 200438 China

International Institute for Intelligent Nanorobots and Nanosystems, Neuromodulation and Brain‐machine‐interface Centre Fudan University Shanghai 200438 China

Yiwu Research Institute of Fudan University Yiwu Zhejiang 322000 China

Institute of Science and Technology for Brain‐Inspired Intelligence Fudan University Shanghai 200438 China

Institute of Mechanics and Computational Engineering Department of Aeronautics and Astronautics & College of Intelligent Robotics and Advanced Manufacturing Fudan University Shanghai 200433 China

State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan University Shanghai 200433 China

Department of Electronic Engineering Beijing National Research Center for Information Science and Technology Center for Flexible Electronics Technology Tsinghua University Beijing 100084 China

IDG/McGovern Institute for Brain Research Tsinghua University Beijing 100084 China

State Key Laboratory of Integrated Chips and Systems Frontier Institute of Chip and System Fudan University Shanghai 200438 China

Funding

National Natural Science Foundation of China · Science and Technology Commission of Shanghai Municipality · Shanghai Municipal Education Commission

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