New Perspectives on Semiconducting Conjugated Oligomers for Neuromodulation in Hydra vulgaris (Adv. Mater. Interfaces 20/2025)

Neuromodulation Image of the tentacle writhing behavior evoked in the small freshwater polyp Hydra vulgaris upon treatment with the semiconductor conjugated oligomer ETE-S. Hydra is an attractive animal model for neuromodulation due to its limited behavioral capacity and a nervous system organized in spatially defined neuronal networks, which can promptly response to precise interrogation. In article 2400962, Silvia Santillo, Claudia Tortiglione, and co-workers review recent data on the double function showed by thiophene based trimer in Hydra, showing intriguing possibilities offered by this model organism in the field of organic bioelectronics for both neuromodulation and in situ production of conducting interfaces.