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journal article·2024-01Open access

Biotoxicity of Halide Perovskites in Mice

Guixiang Li, Yong‐Tao Liu, Feng Yang, Meng Li, Zuhong Zhang, Jorge Pascual, Zhao‐Kui Wang, Shi‐Zhe Wei, Xin‐Yuan Zhao, Hai‐Rui Liu, Jin‐Bo Zhao, Chieh‐Ting Lin, Jun‐Ming Li, Zhe Li, Antonio Abate, Irene Cantone

Advanced Materials· Volume 36· Issue 2
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Abstract

Abstract Halide perovskites are crystalline semiconductors with exceptional optoelectronic properties, rapidly developing toward large‐scale applications. Lead (II) (Pb2+) is the core element used to prepare halide perovskites. Pb2+ can displace key 2+ elements, including calcium, zinc and iron, that regulate vital physiological functions. Sn2+ can replace Pb2+ within the perovskite structure and, if accidentally dispersed in the environment, it readily oxidizes to Sn4+, which is compatible with physiological functions and thus potentially safe. The 3+ salt bismuth (III) (Bi3+) is also potentially safe for the same reason and useful to prepare double perovskites. Here, this work studies the biotoxicity of Pb, Sn, and Bi perovskites in mice for the first time. This work analyses histopathology and growth of mice directly exposed to perovskites and investigate the development of their offspring generation. This study provides the screening of organs and key physiological functions targeted by perovskite exposure to design specific studies in mammalians.
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Research context

Electronic materials

OpenAlex topics: Perovskite Materials and Applications · Sulfur Compounds in Biology

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Lab for Special Functional Materials Ministry of Education National & Local Joint Engineering Research Center for High‐efficiency Display and Lighting Technology School of Materials Science and Engineering and Collaborative Innovation Center of Nano Functional Materials and Applications Henan University Kaifeng 475004 China

Helmholtz‐Zentrum Berlin für Materialien und Energie Kekuléstraße 5 12489 Berlin Germany

Department of Life Science and Technology Xinxiang Medical University Xinxiang 453002 China

Henan Key Laboratory of Photovoltaic Materials School of Physics Henan Normal University Xinxiang 453007 China

Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon‐Based Functional Materials & Devices Joint International Research Laboratory of Carbon‐Based Functional Materials and Devices Soochow University Suzhou 215123 China

Department of Chemical Engineering National Chung Hsing University 145 Xingda Rd. South Dist. Taichung City 40227 Taiwan

School of Engineering and Materials Science (SEMS) Queen Mary University of London London E1 4NS UK

Department of Chemical Materials and Production Engineering University of Naples Federico II Piazzale Tecchio 80 Naples Fuorigrotta 80125 Italy

Department of Molecular Medicine and Medical Biotechnology University of Naples Federico II via Pansini 5 Naples 80131 Italy

CNR Istituto di Endocrinologia e Oncologia Sperimentale (IEOS) Via Pansini, 5 Naples 80131 Italy

Funding

National Natural Science Foundation of China · HORIZON EUROPE European Research Council

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