Supported Lipid Bilayers Coupled to Organic Neuromorphic Devices Modulate Short‐Term Plasticity in Biomimetic Synapses

Abstract Synaptic plasticity is a fundamental process for neuronal communication and is involved in neurodegeneration. This process has been recently exploited to inspire the design of next‐generation bioelectronic platforms. Neuromorphic devices have emerged as ideal candidates in mimicking brain functionalities, thanks to their ionic‐to‐electronic signal transduction, biocompatibility, and their ability to display short‐ and long‐term memory as biological synapses. However, these devices still fail in bridging the gap between electronics and biological systems due to the lack of biomimetic features. Here, a biomembrane‐based organic electrochemical transistor (OECT) is implemented and the supported‐lipid‐bilayer‐mediated short‐term depression of the device is investigated. After morphological and electrical characterization of the lipid bilayer, its ionic barrier behavior is exploited to enhance the neuromorphic operation of the OECT. Such biomimetic neuromorphic devices pave the way toward the implementation of synapses‐resembling in vitro platforms to investigate and characterize neurodegenerative processes involving synaptic plasticity loss.