DataVXAdvanced MaterialsPaper
journal article·2021-12

A Regioselectively Oxidized 2D Bi/BiOx Lateral Nano‐Heterostructure for Hypoxic Photodynamic Therapy

Meng Qiu, Dou Wang, Hao Huang, Teng Yin, Wenli Bao, Bin Zhang, Zhongjian Xie, Ni Xie, Zongze Wu, Chenchen Ge, Qi Wang, Meng Gu, Hilliard L. Kutscher, Liping Liu, Shiyun Bao, Paras N. Prasad, Han Zhang

Advanced Materials· Volume 33· Issue 49
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Source abstract

Abstract

Abstract Optoelectronic science and 2D nanomaterial technologies are currently at the forefront of multidisciplinary research and have numerous applications in electronics and photonics. The unique energy and optically induced interfacial electron transfer in these nanomaterials, enabled by their relative band alignment characteristics, can provide important therapeutic modalities for healthcare. Given that nano‐heterostructures can facilitate photoinduced electron–hole separation and enhance generation of reactive oxygen species (ROS), 2D nano‐heterostructure‐based photosensitizers can provide a major advancement in photodynamic therapy (PDT), to overcome the current limitations in hypoxic tumor microenvironments. Herein, a bismuthene/bismuth oxide (Bi/BiOx)‐based lateral nano‐heterostructure synthesized using a regioselective oxidation process is introduced, which, upon irradiation at 660 nm, effectively generates 1O2 under normoxia but produces cytotoxic •OH and H2 under hypoxia, which synergistically enhances PDT. Furthermore, this Bi/BiOx nano‐heterostructure is biocompatible and biodegradable, and, with the surface molecular engineering used here, it improves tumor tissue penetration and increases cellular uptake during in vitro and in vivo experiments, yielding excellent oxygen‐independent tumor ablation with 660 nm irradiation, when compared with traditional PDT agents.
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Research context

NanomaterialsBiomaterialsElectronic materials

OpenAlex topics: Nanoplatforms for cancer theranostics · Ga2O3 and related materials · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shenzhen Second People's Hospital The First Affiliated Hospital of Shenzhen University Key Laboratory of Optoelectronic Devices Systems of Ministry of Education Guangdong Province Institute of Microscale Optoelectronics Shenzhen University Shenzhen 518060 P. R. China

Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education Ocean University of China Qingdao 266100 P. R. China

Shenzhen People's Hospital (The First Affiliated Hospital) Southern University of Science and Technology Shenzhen 518020 P. R. China

Department of Materials Science and Engineering South University of Science and Technology Shenzhen 518055 P. R. China

Institute for Lasers, Photonics, and Biophotonics Department of Chemistry University at Buffalo The State University of New York Buffalo NY 14260 USA

Department of Medicine University at Buffalo The State University of New York Buffalo NY 14203 USA

Department of Anesthesiology University at Buffalo The State University of New York Buffalo NY 14203 USA

Funding

National Natural Science Foundation of China · Taishan Scholar Project of Shandong Province · Natural Science Foundation of Guangdong Province

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