New Silk Road: From Mesoscopic Reconstruction/Functionalization to Flexible Meso‐Electronics/Photonics Based on Cocoon Silk Materials

Abstract Two of the key questions to be addressed are whether and how one can turn cocoon silk into fascinating materials with different electronic and optical functions so as to fabricate the flexible devices. In this review, a comprehensive overview of the unique strategy of mesoscopic functionalization starting from silk fibroin (SF) materials to the fabrication of various meso flexible SF devices is presented. Notably, SF materials with novel and enhanced properties can be achieved by mesoscopically reconstructing the hierarchical structures of SF materials. This is based on rerouting the refolding process of SF molecules by meso‐nucleation templating. As‐acquired functionalized SF materials can be applied to fabricate bio‐compatible/degradable flexible/implantable meso‐optical/electronic devices of various types. Consequently, functionalized SF can be fabricated into optical elements, that is, nonlinear photonic and fluorescent components, and make it possible to construct silk meso‐electronics with high‐performance. These advances enable the applications of SF‐material based devices in the areas of physical and biochemical sensing, meso‐memristors, transistors, brain electrodes, and energy generation/storage, applicable to on‐skin long‐term monitoring of human physiological conditions, and in‐body sensing, information processing, and storage.