journal article·2021-04Open access

Organic thin film transistors‐based biosensors

Chenfang Sun, Xue Wang, Muhammad Aminu Auwalu, Shanshan Cheng, Wenping Hu

EcoMat· Volume 3· Issue 2

Abstract

Abstract Organic thin film transistors (OTFTs)‐based biosensors are widely applied as advanced biosensing platforms by virtue of their inherent ability to transfer and amplify received biological signals into electrical signals. Nevertheless, the development of OTFTs‐based biosensors with excellent sensitivity, selectivity, and stability for specific biological processes remains a major challenge. This mini review focuses on recent achievements in OTFTs‐based biosensors since 2010. Specifically, three types of OTFTs, specifically organic field‐effect transistors (OFETs), electrolyte‐gated OFETs (EGOFETs), and organic electrochemical transistors (OECTs) are summarized in terms of the key strategies required for high‐performance bioelectronics. Additionally, various OTFTs‐based biosensors, such as ions, glucose, nucleic acids, proteins, and cells are described in terms of their working principles. This mini review highlights the uses of OTFTs for a broad range of research applications with a focus on designing novel OTFTs‐based biosensors.image
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Conducting polymers and applications · Organic Electronics and Photovoltaics · Analytical Chemistry and Sensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Science Tianjin University Tianjin China

Joint School of National University of Singapore and Tianjin University, Fuzhou International Campus, Tianjin University Fuzhou China

Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids Institution of Chemistry, Chinese Academy of Sciences Beijing China

Funding

National Natural Science Foundation of China

References (100+)

Show source-provided references
1. 10.1002/adma.20180005110.1002/adma.201800051 ↗
2. 10.1002/advs.20170105310.1002/advs.201701053 ↗
3. 10.1016/j.snb.2015.02.03810.1016/j.snb.2015.02.038 ↗
4. Biodegradable and flexible arterial‐pulse sensor for the wireless monitoring of blood flow10.1038/s41551-018-0336-5 ↗
5. 10.1002/adma.20140026310.1002/adma.201400263 ↗
6. 10.1021/cm802530x10.1021/cm802530x ↗
7. 10.2116/analsci.18SDN0210.2116/analsci.18SDN02 ↗
8. The immobilization and electrical response of single‐stranded DNA molecules on pentacene transistors10.1063/1.3623438 ↗
9. 10.1016/j.chempr.2018.03.00710.1016/j.chempr.2018.03.007 ↗
10. Organic transistors with ordered nanoparticle arrays as a tailorable platform for selective, in situ detection10.1021/nn204830b ↗
11. 10.1016/j.orgel.2020.10579410.1016/j.orgel.2020.105794 ↗
12. 10.1016/j.bios.2018.04.05110.1016/j.bios.2018.04.051 ↗
13. 10.1021/acsami.6b0551510.1021/acsami.6b05515 ↗
14. 10.1002/anie.20191639710.1002/anie.201916397 ↗
15. 10.1002/adma.20170484310.1002/adma.201704843 ↗
16. 10.1016/j.bios.2020.11225110.1016/j.bios.2020.112251 ↗
17. 10.1038/ncomms395410.1038/ncomms3954 ↗
18. 10.1002/aelm.20170020910.1002/aelm.201700209 ↗
19. 10.1007/s00216-016-9502-310.1007/s00216-016-9502-3 ↗
20. 10.1063/1.152723310.1063/1.1527233 ↗
21. 10.1039/c3tc31412j10.1039/c3tc31412j ↗
22. 10.1002/adfm.20170001810.1002/adfm.201700018 ↗
23. 10.1002/adfm.20170099910.1002/adfm.201700999 ↗
24. 10.1016/j.scib.2020.03.01310.1016/j.scib.2020.03.013 ↗
25. 10.1038/ncomms1003210.1038/ncomms10032 ↗
26. 10.1021/jacs.7b0938110.1021/jacs.7b09381 ↗
27. 10.1038/3500660310.1038/35006603 ↗
28. 10.1039/c1cc10321k10.1039/c1cc10321k ↗
29. 10.3389/fchem.2019.0066710.3389/fchem.2019.00667 ↗
30. 10.1016/j.orgel.2014.06.00210.1016/j.orgel.2014.06.002 ↗
31. 10.1038/srep0075410.1038/srep00754 ↗
32. 10.1002/adma.20120131810.1002/adma.201201318 ↗
33. 10.1002/adma.20180195110.1002/adma.201801951 ↗
34. 10.1038/s41557-018-0200-y10.1038/s41557-018-0200-y ↗
35. 10.1038/nature0772710.1038/nature07727 ↗
36. 10.1021/ar900087310.1021/ar9000873 ↗
37. 10.1002/adma.20180183010.1002/adma.201801830 ↗
38. 10.1002/aelm.20190135210.1002/aelm.201901352 ↗
39. 10.1002/aelm.20190024910.1002/aelm.201900249 ↗
40. 10.1021/acsami.0c0420810.1021/acsami.0c04208 ↗
41. 10.1039/D0TC01536A10.1039/D0TC01536A ↗
42. 10.1126/sciadv.150185610.1126/sciadv.1501856 ↗
43. 10.1002/adfm.20140453510.1002/adfm.201404535 ↗
44. 10.1038/ncomms935610.1038/ncomms9356 ↗
45. 10.1038/nnano.2015.32410.1038/nnano.2015.324 ↗
46. 10.1002/adma.20160223710.1002/adma.201602237 ↗
47. 10.1016/j.bios.2016.02.03610.1016/j.bios.2016.02.036 ↗
48. 10.1002/adfm.20160650610.1002/adfm.201606506 ↗
49. 10.5796/electrochemistry.18-6-E267210.5796/electrochemistry.18-6-E2672 ↗
50. Multifunctional interfacial layers from a one‐step process for effective charge capturing and erasing in low‐voltage‐driven organic thin‐film transistors
51. 10.1002/adma.20180189110.1002/adma.201801891 ↗
52. 10.1002/aelm.20190112710.1002/aelm.201901127 ↗
53. 10.1002/adma.20100407110.1002/adma.201004071 ↗
54. 10.1016/j.orgel.2012.10.02710.1016/j.orgel.2012.10.027 ↗
55. 10.1002/open.20170007010.1002/open.201700070 ↗
56. 10.1002/adma.20120358710.1002/adma.201203587 ↗
57. 10.1039/C7MH00887B10.1039/C7MH00887B ↗
58. 10.1039/C5TB00243E10.1039/C5TB00243E ↗
59. 10.1016/j.bios.2017.12.04110.1016/j.bios.2017.12.041 ↗
60. 10.1007/s00216-011-5363-y10.1007/s00216-011-5363-y ↗
61. 10.1016/j.orgel.2011.09.02510.1016/j.orgel.2011.09.025 ↗
62. 10.1002/adma.20100231310.1002/adma.201002313 ↗
63. 10.1039/C9NR06096K10.1039/C9NR06096K ↗
64. 10.1021/acs.chemmater.8b0226010.1021/acs.chemmater.8b02260 ↗
65. Electrochemical gating of a hydrophobic organic semiconductor with aqueous media10.1016/j.tsf.2018.11.032 ↗
66. 10.1039/c3tb20340a10.1039/c3tb20340a ↗
67. 10.1039/c3tb00525a10.1039/c3tb00525a ↗
68. 10.1039/C3TB21491E10.1039/C3TB21491E ↗
69. 10.1016/j.bios.2016.01.01210.1016/j.bios.2016.01.012 ↗
70. 10.1088/2058-8585/aad0cb10.1088/2058-8585/aad0cb ↗
71. 10.1063/1.187305110.1063/1.1873051 ↗
72. 10.1063/1.358188210.1063/1.3581882 ↗
73. 10.1021/am100154e10.1021/am100154e ↗
74. 10.1063/1.293629610.1063/1.2936296 ↗
75. 10.1063/1.152769810.1063/1.1527698 ↗
76. 10.1016/j.snb.2008.08.00910.1016/j.snb.2008.08.009 ↗
77. 10.1039/c0cc02064h10.1039/c0cc02064h ↗
78. 10.1039/c3tb20451k10.1039/c3tb20451k ↗
79. 10.1016/j.bios.2008.07.03010.1016/j.bios.2008.07.030 ↗
80. 10.1002/adma.20100079010.1002/adma.201000790 ↗
81. 10.1002/adma.20120299610.1002/adma.201202996 ↗
82. 10.1016/j.bios.2018.01.03510.1016/j.bios.2018.01.035 ↗
83. 10.1016/j.orgel.2013.12.01610.1016/j.orgel.2013.12.016 ↗
84. 10.1021/ja107088m10.1021/ja107088m ↗
85. 10.1016/j.bios.2011.03.03110.1016/j.bios.2011.03.031 ↗
86. 10.1021/acs.analchem.6b0352210.1021/acs.analchem.6b03522 ↗
87. 10.1021/nn305903q10.1021/nn305903q ↗
88. 10.1002/adma.20100097110.1002/adma.201000971 ↗
89. 10.1021/acsami.7b0938410.1021/acsami.7b09384 ↗
90. 10.1002/adbi.20190020410.1002/adbi.201900204 ↗
91. 10.1002/adma.20130261510.1002/adma.201302615 ↗
92. 10.1039/b811606g10.1039/b811606g ↗
93. 10.1002/adhm.20160049410.1002/adhm.201600494 ↗
94. 10.1002/admt.20160004210.1002/admt.201600042 ↗
95. Multianalyte detection of cancer biomarkers in human serum using a label‐free field effect transistor biosensor
96. 10.1039/C7TC04389A10.1039/C7TC04389A ↗
97. 10.3390/polym1101010710.3390/polym11010107 ↗
98. 10.1002/smll.20190085410.1002/smll.201900854 ↗
99. The role of weak molecular dopants in enhancing the performance of solution‐processed organic field‐effect transistors10.1002/aelm.201800547 ↗
100. 10.1002/advs.20170060910.1002/advs.201700609 ↗