Advanced Healthcare Materials

Graphical Abstract This review highlights the strategies to enhance the reactive oxygen species generation through optimizing photoinduced electron transfer and energy transfer processes of photosensitizers (PSs). The approaches that combine photodynamic therapy with other therapeutics (e.g., chemotherapy, photothermal therapy, and radiotherapy) and the targeted delivery in cancer cells or tumor tissue are introduced. The main challenges for the clinical application of PSs are also discussed.