Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015)
Source abstract
Abstract
One major obstacle to the routine deployment of stem cell-derived cells is their instability in culture. On page 1820 David C. Hay and co-workers describe the use of a synthetic polymer surface. The image shows stem cell-derived hepatocytes replated on this polyurethane surface. Importantly the cells express Zonal Occludin (green stain) at the cell surface, which indicates that the cells display elements of polarization. The blue stain is DAPI, which demarks the nucleus.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Biomedical Ethics and Regulation
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Affiliations
MRC Centre for Regenerative Medicine University of Edinburgh 5 Little France Drive Edinburgh EH16 4UU UK
Faculty of Life Sciences Michael Smith Building Oxford Road Manchester M13 9PT UK
MRC Centre for Inflammation Research University of Edinburgh 47 Little France Crescent Edinburgh EH16 4TJ UK
School of Chemistry University of Edinburgh West Mains Road Edinburgh EH9 3FJ UK
References
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