DataVXAdvanced Healthcare MaterialsPaper
journal article·2023-10Open access

Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery

Ying Li, Jung Seung Lee, Ameya R. Kirtane, Mengyuan Li, Charles William Coffey, Kaitlyn Hess, Aaron Lopes, Joy Collins, Siddartha Tamang, Keiko Ishida, Alison Hayward, Jacob Wainer, Adam J. Wentworth, Giovanni Traverso

Advanced Healthcare Materials· Volume 12· Issue 27
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Source abstract

Abstract

Abstract Patient adherence to chronic therapies can be suboptimal, leading to poor therapeutic outcomes. Dosage forms that enable reduction in dosing frequency stand to improve patient adherence. Variation in gastrointestinal transit time, inter‐individual differences in gastrointestinal physiology and differences in physicochemical properties of drugs represent challenges to the development of such systems. To this end, a small intestine‐targeted drug delivery system is developed, where prolonged gastrointestinal retention and sustained release are achieved through tissue adhesion of drug pills mediated by an essential intestinal enzyme catalase. Here proof‐of‐concept pharmacokinetics is demonstrated in the swine model for two drugs, hydrophilic amoxicillin and hydrophobic levodopa. It is anticipated that this system can be applicable for many drugs with a diverse of physicochemical characteristics.
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Research context

OpenAlex topics: Advanced Drug Delivery Systems · Oral and gingival health research · Drug Solubulity and Delivery Systems

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Haidian District Beijing 100193 P. R. China

David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA 02139 USA

Department of Intelligent Precision Healthcare Convergence Sungkyunkwan University Suwon 16419 South Korea

Department of Biomedical Engineering Sungkyunkwan University Suwon 16419 South Korea

Division of Gastroenterology Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA

Faculty of Applied Science & Engineering University of Toronto Toronto ON M5S1A4 Canada

Department of Biological Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA

Division of Comparative Medicine Massachusetts Institute of Technology Cambridge MA 02139 USA

Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA

Funding

China Scholarship Council · Massachusetts Institute of Technology · Bill and Melinda Gates Foundation

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