DataVXAdvanced Healthcare MaterialsPaper
journal article·2024-05

Fast and Stable Antibacterial Coating of Photosensitive Aggregation‐Induced Emission Luminogens for Disinfection on Medical Devices

Mian Chen, Ruihua Dong, Jiayi Song, Jie Qi, Jiangjiang Zhang, Zheng Zhao, Wentian Zhang, Ying Li, Ben Zhong Tang

Advanced Healthcare Materials· Volume 13· Issue 13
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Source abstract

Abstract

Abstract Aggregation‐induced emission luminogens (AIEgens) are promising photosensitizers that have exhibited excellent antibacterial ability with abundant reactive oxygen species (ROS) generation. TTCPy‐PF6 and TTCPy‐Br are deposited on the surface of diverse solid substrates through plasma‐assistant electrostatic self‐assembly. The AIEgens‐covered coating can effectively eliminate different pathogenic Gram‐positive (G+) bacteria and even their multidrug‐resistant (MDR) mutants with negligible side effects such as cytotoxicity, hemolysis, and inflammation. Moreover, the AIEgen‐coated surface can maintain high stability for long‐time antibacterial usage, which is dependent on the ROS‐mediated disruption of the attached bacteria. The AIEgen‐based coatings with broad surface applicability have many advantages in high antibacterial ability, great biocompatibility, and low possibility of antibiotic pollution. The robust antibacterial ability and excellent biological safety of the AIEgen‐based coatings would be helpful for the disinfection of medical devices.
Source: crossref · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Antimicrobial agents and applications · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Innovation Research Center for AIE Pharmaceutical Biology Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology the NMPA and State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences and the Fifth Affiliated Hospital Guangzhou Medical University Guangzhou 511436 China

Clinical Translational Research Center of Aggregation‐Induced Emission The Second Affiliated Hospital School of Medicine School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen 518172 China

Shenzhen Key Laboratory of Smart Healthcare Engineering and Guangdong Provincial Key Laboratory of Advanced Biomaterials Department of Biomedical Engineering Southern University of Science and Technology No 1088, Xueyuan Rd., Nanshan District Shenzhen 518055 China

Funding

National Natural Science Foundation of China

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