journal article·2013-01Open access

Sequence‐Specific Crosslinking of Electrospun, Elastin‐Like Protein Preserves Bioactivity and Native‐Like Mechanics

Patrick L. Benitez, Jeffrey A. Sweet, Helen Fink, Krishna P. Chennazhi, Shantikumar V. Nair, Annika Enejder, Sarah C. Heilshorn

Advanced Healthcare Materials· Volume 2· Issue 1

Abstract

A nanoscale mimic of the extracellular matrix is electrospun from a highly tunable family of elastin-like proteins. A sequence-specific, two-step crosslinking procedure is developed to preserve the nanofiber morphology, elastin-like mechanics, and specific bioactivity. Rodent marrow stromal cells show sequence-specific adhesion on the matrices, which are imaged using label-free coherent anti-Stokes Raman scattering (CARS) microscopy.
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Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine · Silk-based biomaterials and applications

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