DataVXAdvanced Healthcare MaterialsPaper
journal article·2019-02Open access

A Foreign Body Response‐on‐a‐Chip Platform

Fatemeh Sharifi, Su Su Htwe, Martina Righi, Hua Liu, Anna Pietralunga, Ozlem Yesil‐Celiktas, Sushila Maharjan, Byung‐Hyun Cha, Su Ryon Shin, Mehmet Remzi Dokmeci, Nihal Engin Vrana, Amir M. Ghaemmaghami, Ali Khademhosseini, Yu Shrike Zhang

Advanced Healthcare Materials· Volume 8· Issue 4
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Source abstract

Abstract

Abstract Understanding the foreign body response (FBR) and desiging strategies to modulate such a response represent a grand challenge for implant devices and biomaterials. Here, the development of a microfluidic platform is reported, i.e., the FBR‐on‐a‐chip (FBROC) for modeling the cascade of events during immune cell response to implants. The platform models the native implant microenvironment where the implants are interfaced directly with surrounding tissues, as well as vasculature with circulating immune cells. The study demonstrates that the release of cytokines such as monocyte chemoattractant protein 1 (MCP‐1) from the extracellular matrix (ECM)‐like hydrogels in the bottom tissue chamber induces trans‐endothelial migration of circulating monocytes in the vascular channel toward the hydrogels, thus mimicking implant‐induced inflammation. Data using patient‐derived peripheral blood mononuclear cells further reveal inter‐patient differences in FBR, highlighting the potential of this platform for monitoring FBR in a personalized manner. The prototype FBROC platform provides an enabling strategy to interrogate FBR on various implants, including biomaterials and engineered tissue constructs, in a physiologically relevant and individual‐specific manner.
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Research context

PolymersBiomaterials

OpenAlex topics: 3D Printing in Biomedical Research · Neuroscience and Neural Engineering · Microfluidic and Bio-sensing Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USA

School of Mechanical Engineering Sharif University of Technology Tehran 11155‐8639 Iran

Immunology and Immuno‐bioengineering Group School of Life Science Faculty of Medicine and Health Sciences University of Nottingham Nottingham NG7 2RD UK

Department of Bioengineering Faculty of Engineering Ege University Bornova 35100 Izmir, Turkey

The BioRobotics Institute Sant'Anna School of Advanced Studies Piaggio 56025 Italy

Department of Radiology David Geffen School of Medicine University of California‐Los Angeles Los Angeles CA 90095 USA

Department of Bioengineering Department of Chemical and Biomolecular Engineering Henry Samueli School of Engineering and Applied Sciences University of California, Los Angeles Los Angeles CA 90095 USA

California NanoSystems Institute (CNSI) University of California, Los Angeles Los Angeles CA 90095 USA

Biomatériaux et Bioingénierie Institut National de la Santé et de la Recherche Médicale (INSERM) 67085 Strasbourg France

Protip Medical 67000 Strasbourg France

Fédération de Médecine Translationnelle de Strasbourg Fédération des Matériaux et Nanoscience d'Alsace (FMNA) Faculté de Chirurgie Dentaire Université de Strasbourg 67000 Strasbourg France

Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine Zhejiang University School of Medicine Hangzhou 310012 P. R. China

Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province Zhejiang University School of Medicine Hangzhou 310012 P. R. China

Research Institute for Bioscience and Biotechnology Lalitpur 44600 Nepal

Funding

National Institutes of Health · Horizon 2020 Framework Programme

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