journal article·2016-02Open access

Photocleavable Hydrogels for Light‐Triggered siRNA Release

Cong Truc Huynh, Minh Khanh Nguyen, Gulen Yesilbag Tonga, Lionel Longé, Vincent M. Rotello, Eben Alsberg

Advanced Healthcare Materials· Volume 5· Issue 3

Abstract

A photocleavable hydrogel system for on-demand delivery of genetic material is reported. The release of short interfering RNAs can be triggered by the application of UV light without any loss in bioactivity. This approach provides a promising external stimulus-based nucleic acid delivery platform for applications in disease therapeutics and tissue regeneration. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques · Conducting polymers and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomedical Engineering Case Western Reserve University 10900 Euclid Avenue Cleveland OH 44106 USA

Department of Chemistry University of Massachusetts 710 North Pleasant Street Amherst MA 01003 USA

Département Chimie Physique École Nationale Supérieure de Chimie de Biologie et de Physique 16 avenue Pey Berland 33607 PESSAC CEDEX France

Department of Orthopaedic Surgery Case Western Reserve University 10900 Euclid Avenue Cleveland OH 44106 USA

Funding

National Institutes of Health · Department of Defense Congressionally Directed Medical Research Programs

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