Local Delivery of PHD2 siRNA from ROS‐Degradable Scaffolds to Promote Diabetic Wound Healing
Source abstract
Abstract
Small interfering RNA (siRNA) delivered from reactive oxygen species-degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal-urethane) scaffolds implanted in diabetic wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2, thereby increasing the expression of progrowth genes and increasing vasculature, proliferating cells, and tissue development in diabetic wounds.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine · Mesenchymal stem cell research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biomedical Engineering Vanderbilt University Nashville TN 37235 USA
Department of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center Nashville TN 37232 USA
Department of Plastic Surgery Vanderbilt University Medical Center Nashville TN 37232 USA
Medical Research Service Veterans Affairs Tennessee Valley Healthcare System Nashville TN 37212 USA
Department of Chemical and Biomolecular Engineering Vanderbilt University Nashville TN 37235 USA
Funding
National Institutes of Health · National Science Foundation
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