DataVXAdvanced Healthcare MaterialsPaper
journal article·2024-09

Injectable Thermosensitive Gel CH‐BPNs‐NBP for Effective Periodontitis Treatment through ROS‐Scavenging and Jaw Vascular Unit Protection

Yuli Wang, Yuqing Yuan, Ruyu Wang, Tianxiao Wang, Fanyi Guo, Yifeng Bian, Tianyao Wang, Qian Ma, Hua Yuan, Yifei Du, Jianliang Jin, Huijun Jiang, Feng Han, Jiandong Jiang, Yongchu Pan, Lulu Wang, Fan Wu

Advanced Healthcare Materials· Volume 13· Issue 22
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Source abstract

Abstract

Abstract Periodontitis, a prevalent inflammatory condition in the oral cavity, is closely associated with oxidative stress‐induced tissue damage mediated by excessive reactive oxygen species (ROS) production. The jaw vascular unit (JVU), encompassing both vascular and lymphatic vessels, plays a crucial role in maintaining tissue fluid homeostasis and contributes to the pathological process in inflammatory diseases of the jaw. This study presents a novel approach for treating periodontitis through the development of an injectable thermosensitive gel (CH‐BPNs‐NBP). The gel formulation incorporates black phosphorus nanosheets (BPNs), which are notable for their ROS‐scavenging properties, and dl‐3‐n‐butylphthalide (NBP), a vasodilator that promotes lymphatic vessel function within the JVU. These results demonstrate that the designed thermosensitive gel serve as a controlled release system, delivering BPNs and NBP to the site of inflammation. CH‐BPNs‐NBP not only protects macrophages and human lymphatic endothelial cells from ROS attack but also promotes M2 polarization and lymphatic function. In in vivo studies, this work observes a significant reduction in inflammation and tissue damage, accompanied by a notable promotion of alveolar bone regeneration. This research introduces a promising therapeutic strategy for periodontitis, leveraging the unique properties of BPNs and NBP within an injectable thermosensitive gel.
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Research context

Nanomaterials

OpenAlex topics: Oral microbiology and periodontitis research · Scientific and Engineering Research Topics · Dental Radiography and Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Oral and Maxillofacial Surgery The Affiliated Stomatological Hospital of Nanjing Medical University Jiangsu Province Key Laboratory of Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical University Nanjing Jiangsu 210029 China

Department of Orthodontic The Affiliated Stomatological Hospital of Nanjing Medical University Jiangsu Province Key Laboratory of Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical University Nanjing Jiangsu 210029 China

Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases Ministry of Education International Joint Laboratory for Drug Target of Critical Illnesses School of Pharmacy Nanjing Medical University Nanjing 211166 China

Department of Periodontology, The Affiliated Stomatological Hospital of Nanjing Medical University Jiangsu Province Key Laboratory of Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical University Nanjing Jiangsu 210029 China

Department of General Dentistry The Affiliated Stomatological Hospital of Nanjing Medical University Jiangsu Province Key Laboratory of Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical University Nanjing Jiangsu 210029 China

Department of Human Anatomy, Research Centre for Bone and Stem Cells, School of Basic Medical Sciences, Key Laboratory for Aging & Disease, School of Biomedical Engineering and informatics Nanjing Medical University Nanjing Jiangsu 211166 China

Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China

Funding

Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China

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