DataVXAdvanced Healthcare MaterialsPaper
journal article·2024-06Open access

Flexible Polymer Electrodes for Stable Prosthetic Visual Perception in Mice

Corinne Orlemann, Christian Boehler, Roxana N. Kooijmans, Bingshuo Li, Maria Asplund, Pieter R. Roelfsema

Advanced Healthcare Materials· Volume 13· Issue 15
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Source abstract

Abstract

Abstract Brain interfaces that can stimulate neurons, cause minimal damage, and work for a long time will be central for future neuroprosthetics. Here, the long‐term performance of highly flexible, thin polyimide shanks with several small (<15 µm) electrodes during electrical microstimulation of the visual cortex, is reported. The electrodes exhibit a remarkable stability when several billions of electrical pulses are applied in vitro. When the devices are implanted in the primary visual cortex (area V1) of mice and the animals are trained to detect electrical microstimulation, it is found that the perceptual thresholds are 2–20 microamperes (µA), which is far below the maximal currents that the electrodes can withstand. The long‐term functionality of the devices in vivo is excellent, with stable performance for up to more than a year and little damage to the brain tissue. These results demonstrate the potential of thin floating electrodes for the long‐term restoration of lost sensory functions.
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Research context

PolymersBiomaterials

OpenAlex topics: Neuroscience and Neural Engineering · Conducting polymers and applications · Advanced Memory and Neural Computing

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Vision and Cognition Netherlands Institute for Neuroscience Royal Netherlands Academy of Arts and Sciences Amsterdam 1105 BA The Netherlands

Department of Microsystems Engineering (IMTEK) University of Freiburg 79110 Freiburg Germany

BrainLinks‐BrainTools Center University of Freiburg 79110 Freiburg Germany

Institute for Neuroscience and Medicine (INM‐1) Forschungszentrum Jülich 52428 Jülich Germany

Department of Microtechnology and Nanoscience Chalmers University of Technology Gothenburg 412 96 Sweden

Laboratory of Visual Brain Therapy Sorbonne Université Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique Institut de la Vision Paris F‐75012 France

Department of Integrative Neurophysiology Centre for Neurogenomics and Cognitive Research VU University Amsterdam 1081 HV The Netherlands

Department of Neurosurgery Amsterdam University Medical Center University of Amsterdam Amsterdam 1105 AZ The Netherlands

Funding

HORIZON EUROPE European Research Council

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