DataVXAdvanced Healthcare MaterialsPaper
journal article·2023-04Open access

Preparation of 2D Polyaniline/MoO3−x Superlattice Nanosheets via Intercalation‐Induced Morphological Transformation for Efficient Chemodynamic Therapy

Tingting Hu, Baoli Xue, Fanqi Meng, Lu Ma, Yonghua Du, Shilong Yu, Ruquan Ye, Hai Li, Qinghua Zhang, Lin Gu, Zhan Zhou, Ruizheng Liang, Chaoliang Tan

Advanced Healthcare Materials· Volume 12· Issue 11
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Abstract

Abstract Organic intercalation of layered nanomaterials is an attractive strategy to fabricate organic/inorganic superlattices for a wide range of promising applications. However, the synthesis of 2D organic/inorganic superlattice nanosheets remains a big challenge. Herein, the preparation of 2D polyaniline/MoO3−x (PANI/MoO3−x) superlattice nanosheets via intercalation‐induced morphological transformation from MoO3 nanobelts, as efficient Fenton‐like reagents for chemodynamic therapy (CDT), is reported. Micrometer‐long MoO3 nanobelts are co‐intercalated with Na+/H2O followed by the guest exchange with aniline monomer for in situ polymerization to obtain PANI/MoO3−x nanosheets. Intriguingly, the PANI intercalation can induce the morphological transformation from long MoO3 nanobelts to 2D PANI/MoO3−x nanosheets along with the partial reduction of Mo6+ to Mo5+, and generation of rich oxygen vacancies. More importantly, thanks to the PANI intercalation‐induced activation, the PANI/MoO3−x nanosheets exhibit excellent Fenton‐like catalytic activity for generation of hydroxyl radical (·OH) by decomposing H2O2 compared with the MoO3 nanobelts. It is speculated that the good conductivity of PANI can facilitate electron transport during the Fenton‐like reaction, thereby enhancing the efficiency of CDT. Thus, the polyvinylpyrrolidone‐modified PANI/MoO3−x nanosheets can function as Fenton‐like reagents for highly efficient CDT to kill cancer cells and eradicate tumors.
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Research context

PolymersNanomaterialsCatalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Carbon and Quantum Dots Applications · Conducting polymers and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China

College of Chemistry and Chemical Engineering Henan Key Laboratory of Function‐Oriented Porous Materials Luoyang Normal University Luoyang 471934 P. R. China

Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 P. R. China

National Synchrotron Light Source II Brookhaven National Laboratory Upton Upton NY 11973 USA

Institute of Advanced Materials (IAM) and Key Laboratory of Flexible Electronics (KLoFE) Nanjing Tech University (NanjingTech) 30 South Puzhu Road Nanjing 211816 P. R. China

Department of Chemistry City University of Hong Kong Kowloon Hong Kong SAR 999077 P. R. China

Shenzhen Research Institute City University of Hong Kong Shenzhen 518057 P. R. China

School of Materials Science and Engineering Tsinghua University Beijing 100084 P. R. China

Center of Super‐Diamond and Advanced Films (COSDAF) City University of Hong Kong Kowloon Hong Kong SAR 999077 P. R. China

Funding

National Natural Science Foundation of China · City University of Hong Kong · Natural Science Foundation of Beijing Municipality · U.S. Department of Energy · Office of Science · Brookhaven National Laboratory

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