Multifunctional Cu₂Se/F127 Hydrogel with SOD‐Like Enzyme Activity for Efficient Wound Healing

Abstract Free radicals are secreted following skin damage and cause oxidative stress and inflammatory reactions that increase the difficulty of wound healing. In this study, copper‐based nanozyme Cu₂Se nanosheets (NSs) are synthesized by an anion‐exchange strategy and apply to wounds with F127 hydrogels to investigate the healing effect of this nanozyme composite hydrogels on wounds. Cu₂Se NSs have a large number of catalytically active centers, are simple to synthesize, require few reaction conditions and have a short synthesis cycle. In vitro experiments have shown that Cu₂Se NSs possess superoxide dismutase (SOD)‐like activity and nitrogen radical scavenging activity and promote angiogenesis and fibroblast migration. The doping of Cu₂Se NSs into the F127 hydrogel does not have a significantly affect on the properties of the hydrogel. This hybridized hydrogel not only adapts to the irregular and complex morphology of acute wounds but also prolongs the duration of nanozyme action on the wound, thus promoting wound healing. Transcriptomic analysis further reveals the potential therapeutic mechanism of the Cu₂Se/F127 hydrogel in promoting acute wound healing. Animal experiments have shown that the Cu₂Se/F127 hydrogel has good biosafety. The Cu₂Se/F127 hydrogel provides an innovative idea for the development of hydrogel dressings for the treatment of acute wounds.