Nature‐Skin‐Derived e‐Skin as Versatile “Wound Therapy‐Health Monitoring” Bioelectronic Skin‐Scaffolds: Skin to Bio‐e‐Skin

Abstract Electronic skins (e‐skins) have the potential to turn into breakthroughs in biomedical applications. Herein, a novel acellular dermal matrix (ADM)‐based bioelectronic skin (e‐ADM) is used to fabricate versatile “wound therapy‐health monitoring” tissue‐nanoengineered skin scaffolds via a facile “one‐pot” bio‐compositing strategy to incorporate the conductive carbon nanotubes and self‐assembled micro‐copper oxide microspheres with a cicada‐wing‐like rough surface and nanocone microstructure. The e‐ADM exhibits robust tensile strength (22 MPa), flexibility, biodegradability, electroactivity, and antibacterial properties. Interestingly, e‐ADM exhibits the pH‐responsive ability for intelligent command between sterilization and wound repair . Additionally, e‐ADM enables accurate real‐time monitoring of human activities, providing a novel flexible e‐skin sensor to record injury and motions. In vitro and in vivo experiments show that with electrical stimulation, e‐ADM could prominently facilitate cell growth and proliferation and further promote full‐thickness skin wound healing, providing a comprehensive therapeutic strategy for smart sensing and tissue repair, guiding the development of high‐performance “wound therapy‐health monitoring” bioelectronic skin‐scaffolds.