journal article·2022-08

Conductive Hydrogel Conduits with Growth Factor Gradients for Peripheral Nerve Repair in Diabetics with Non‐Suture Tape

Yuting Cai, Qun Huang, Penghui Wang, Kaichuang Ye, Zhen Zhao, Haomin Chen, Zhenjing Liu, Hongwei Liu, Hoilun Wong, Mohsen Tamtaji, Kenan Zhang, Feng Xu, Guorui Jin, Lun Zeng, Jianbo Xie, Yucong Du, Zhigang Hu, Dazhi Sun, Jinbao Qin, Xinwu Lu, Zhengtang Luo

Advanced Healthcare Materials· Volume 11· Issue 16
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Abstract

Abstract Diabetic patients suffer from peripheral nerve injury with slow and incomplete regeneration owing to hyperglycemia and microvascular complications. This study develops a graphene‐based nerve guidance conduit by incorporating natural double network hydrogel and a neurotrophic concentration gradient with non‐invasive treatment for diabetics. GelMA/silk fibroin double network hydrogel plays quadruple roles for rapid setting/curing, suitable mechanical supporting, good biocompatibility, and sustainable growth factor delivery. Meanwhile, graphene mesh can improve the toughness of conduit and enhance conductivity of conduit for regeneration. Here, novel silk tapes show quick and tough adhesion of wet tissue by dual mechanism to replace suture step. The in vivo results demonstrate that gradient concentration of netrin‐1 in conduit have better performance than uniform concentration caused by chemotaxis phenomenon for axon extension, remyelination, and angiogenesis. Altogether, GelMA/silk graphene conduit with gradient netrin‐1 and dry double‐sided adhesive tape can significantly promote repairing of peripheral nerve injury and inhibit the atrophy of muscles for diabetics.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nerve injury and regeneration · Graphene and Nanomaterials Applications · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and Technology Shenzhen Guangdong 518055 China

Department of Chemical and Biological Engineering Guangdong‐Hong Kong‐Macao Joint Laboratory for Intelligent Micro‐Nano Optoelectronic Technology William Mong Institute of Nano Science and Technology and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong 999077 P. R. China

Department of Vascular Surgery Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine Shanghai 200011 China

Vascular Center of Shanghai JiaoTong University Shanghai 200011 China

Department of Materials Science and Engineering KAIST Institute for the Nanocentury Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University Xi'an 710049 China

Guangzhou Baiyun Medical Adhesive Co. Ltd Guangzhou Guangdong 510405 P. R. China

Silver Age Engineering Plastics (Dongguan) Co. Ltd Dongguan Guangdong 523187 P. R. China

Funding

Innovation and Technology Commission · Guangdong Science and Technology Department · National Natural Science Foundation of China

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