Enhanced photothermal therapy for tumor ablation: structural and functional insights into Bi2Se3 nanosheets as Light-to-Heat converter
Source abstract
Abstract
Photothermal therapy (PTT) represents a promising advance in oncological treatments, utilizing light-induced heat mediated by photothermal agents to target and destroy cancer cells with high precision. Despite its potential, the clinical application of PTT is often limited by the efficiency of photothermal agents and their biocompatibility, highlighting a crucial need for novel materials that can safely and effectively convert light into therapeutic heat. This study demonstrates the two-dimensional Bi 2 Se 3 nanosheets with tailored nanostructure via a solvothermal process. This study controls over their structural and photothermal properties by accurately optimizing synthesis conditions. In situ experiments provide insights into the crystallographic and phonon characteristics at varying temperatures, underscoring the thermal stability of Bi 2 Se 3 nanosheets. Notably, these nanosheets demonstrate a high photothermal conversion efficiency, rapidly raising the tumor site temperature to 53.1 °C within 180 s, resulting in rapid tumor cell ablation. Significant tumor growth suppression is also observed, with the median survival of mice treated with the particle and light combination extending to 34 days. These findings confirm the stable in vivo thermal properties of Bi 2 Se 3 nanosheets, establishing them as a potent candidate for future photothermal therapy applications.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Gold and Silver Nanoparticles Synthesis and Applications · Photoacoustic and Ultrasonic Imaging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (50)
Show source-provided references
1. Liu Y, Zheng Z. Understanding the global cancer statistics 2022: growing cancer burden. Sci China Life Sci. 2024;67:2274–6. https://doi.org/10.1007/s11427-024-2657-y.10.1007/s11427-024-2657-y ↗
2. Christopher P, Wild EW, Bernard W, Stewart. World Cancer report: Cancer research for Cancer prevention. World Health Organization; 2020.
3. Chhikara BS, Parang K. Global Cancer statistics 2022: the trends projection analysis. Chem Biology Lett. 2023;10:451.
4. Deo SVS, Sharma J, Kumar S. GLOBOCAN 2020 report on global Cancer burden: challenges and opportunities for surgical oncologists. Ann Surg Oncol. 2022;29:6497–500. https://doi.org/10.1245/s10434-022-12151-6.10.1245/s10434-022-12151-6 ↗
5. Di X, Pei Z, Pei Y, James TD. Tumor Microenvironment-oriented MOFs for chemodynamic therapy. Coord Chem Rev. 2023;484:215098. https://doi.org/10.1016/j.ccr.2023.215098.10.1016/j.ccr.2023.215098 ↗
6. Xiong J, Wang X, Kim J, Gong J, Mao Z, Kim JS, Liu Z. Tumor-Activated prodrug with synergistic Anti-Stemness chemical and photodynamic therapies. Adv Funct Mater. 2024;34:2312590. https://doi.org/10.1002/adfm.202312590.10.1002/adfm.202312590 ↗
7. Matyjaszek S, Porubovich H, Sullins K. Laser-induced photothermal ablation of equine dermal melanoma. Equine Veterinary Educ. 2024;37:349–52. https://doi.org/10.1111/eve.14023.10.1111/eve.14023 ↗
8. Wang L, Zhang X, You Z, Yang Z, Guo M, Guo J, Liu H, Zhang X, Wang Z, Wang A, Lv Y, Zhang J, Yu X, Liu J, Chen C. A molybdenum disulfide nanozyme with Charge-Enhanced activity for Ultrasound-Mediated Cascade-Catalytic tumor ferroptosis. Angew Chem Int Ed. 2023;62:e202217448. https://doi.org/10.1002/anie.202217448.10.1002/anie.202217448 ↗
9. Xiong R, Xu RX, Huang C, De Smedt S, Braeckmans K. Stimuli-responsive nanobubbles for biomedical applications. Chem Soc Rev. 2021;50:5746–76. https://doi.org/10.1039/C9CS00839J.10.1039/C9CS00839J ↗
10. He C-Y, Li Y, Zhou Z-H, Liu B-H, Gao X-H. High-Entropy photothermal materials. Adv Mater. 2024;36:2400920. https://doi.org/10.1002/adma.202400920.10.1002/adma.202400920 ↗
11. Liu T, Zhu M, Chang X, Tang X, Yuan P, Tian R, Zhu Z, Zhang Y, Chen X. Tumor-Specific Photothermal-Therapy-Assisted Immunomodulation via multiresponsive adjuvant nanoparticles. Adv Mater. 2023;35:2300086. https://doi.org/10.1002/adma.202300086.10.1002/adma.202300086 ↗
12. Overchuk M, Weersink RA, Wilson BC, Zheng G. Photodynamic and photothermal therapies: synergy opportunities for nanomedicine. ACS Nano. 2023;17:7979–8003. https://doi.org/10.1021/acsnano.3c00891.10.1021/acsnano.3c00891 ↗
13. Wang H, Gao J, Xu C, Jiang Y, Liu M, Qin H, Ye Y, Zhang L, Luo W, Chen B, Du L, Peng F, Li Y, Tu Y. Light-Driven biomimetic nanomotors for enhanced photothermal therapy. Small. 2024;20:2306208. https://doi.org/10.1002/smll.202306208.10.1002/smll.202306208 ↗
14. Žerjav G, Say Z, Zavašnik J, Finšgar M, Langhammer C, Pintar A. Photo, thermal and photothermal activity of TiO2 supported Pt catalysts for plasmon-driven environmental applications. J Environ Chem Eng. 2023;11:110209. https://doi.org/10.1016/j.jece.2023.110209.10.1016/j.jece.2023.110209 ↗
15. Noel L, Khitous A, Molinaro C, Zan H-W, Berling D, Grasset F, Soppera O. Laser direct writing of crystallized TiO2 by photothermal effect induced by gold nanoparticles. Adv Mater Technol. 2024;9:2300407. https://doi.org/10.1002/admt.202300407.10.1002/admt.202300407 ↗
16. Wu J, Wang M, Pan Y, Pang Y, Tang Y, Song C, Zhu J, Zhang X, Huang Q. Synthesis of manganese-oxide and palladium nanoparticles co-decorated polypyrrole/graphene oxide (MnO2@Pd@PPy/GO) nanocomposites for anti-cancer treatment. RSC Adv. 2022;12:23786–95. https://doi.org/10.1039/D2RA03860A.10.1039/D2RA03860A ↗
17. Kumar PP, Lim D-K. Photothermal effect of gold nanoparticles as a nanomedicine for diagnosis and therapeutics. Pharmaceutics. 2023;15(9):2349. https://doi.org/10.3390/pharmaceutics15092349.10.3390/pharmaceutics15092349 ↗
18. Han W, Wei Z, Feng L, Yao M, Zhang H, Zhang S. Single-Site Fe-N-C atom based carbon nanotubes for mutually promoted and synergistic oncotherapy. ACS Appl Mater Interfaces. 2022;14:48356–67. https://doi.org/10.1021/acsami.2c11809.10.1021/acsami.2c11809 ↗
19. Du X, Yang X, Zhang Y, Gao S, Liu S, Ji J, Zhai G. Transdermal delivery system based on heparin-modified graphene oxide for deep transportation, tumor microenvironment regulation, and immune activation. Nano Today. 2022;46:101565. https://doi.org/10.1016/j.nantod.2022.101565.10.1016/j.nantod.2022.101565 ↗
20. Lu CX, Li RY, Miao ZH, Wang F, Zha ZB. Emerging metallenes: synthesis strategies, biological effects and biomedical applications. Chem Soc Rev. 2023;52:2833–65. https://doi.org/10.1039/d2cs00586g.10.1039/d2cs00586g ↗
21. Li XQ, Li WJ, Miao ZH, Lu CX, Ma HN, Xu Y, Gong DY, Xu CY, Zha ZB. Liquid exfoliation of Stanene as degradable nanoagents for NIR-II photothermal therapy. J Mater Sci Technol. 2023;148:186–98. https://doi.org/10.1016/j.jmst.2022.10.090.10.1016/j.jmst.2022.10.090 ↗
22. Mao B, Bao T, Yu J, Zheng L, Qin J, Yin W, Cao M. One-pot synthesis of MoSe2 hetero-dimensional hybrid self-assembled by nanodots and nanosheets for electrocatalytic hydrogen evolution and photothermal therapy. Nano Res. 2017;10:2667–82. https://doi.org/10.1007/s12274-017-1469-7.10.1007/s12274-017-1469-7 ↗
23. He L, Nie T, Xia X, Liu T, Huang Y, Wang X, Chen T. Designing bioinspired 2D MoSe2 nanosheet for efficient Photothermal-Triggered Cancer immunotherapy with reprogramming Tumor-Associated macrophages. Adv Funct Mater. 2019;29:1901240. https://doi.org/10.1002/adfm.201901240.10.1002/adfm.201901240 ↗
24. Jing X, Liu D, Zhang N, Zhao X, Wang J, Wang D, Ji W, She J, Meng L. Engineering Two-dimensional tungsten-doped molybdenum Selenide transformed conformational nanoarchitectonics: trimodal therapeutic nanoagents for enhanced synergistic photothermal/chemodynamic/chemotherapy of breast carcinoma. J Colloid Interface Sci. 2025;678:646–57. https://doi.org/10.1016/j.jcis.2024.09.155.10.1016/j.jcis.2024.09.155 ↗
25. Xu D, Li Z, Li L, Wang J. Insights into the photothermal conversion of 2D MXene nanomaterials: synthesis, mechanism, and applications. Adv Funct Mater. 2020;30:2000712. https://doi.org/10.1002/adfm.202000712.10.1002/adfm.202000712 ↗
26. Wu Q, Tan L, Liu X, Li Z, Zhang Y, Zheng Y, Liang Y, Cui Z, Zhu S, Wu S. The enhanced near-infrared photocatalytic and photothermal effects of MXene-based heterojunction for rapid bacteria-killing. Appl Catal B. 2021;297:120500. https://doi.org/10.1016/j.apcatb.2021.120500.10.1016/j.apcatb.2021.120500 ↗
27. Lin T-H, Wu M-C, Lin Y-T, Tsao C-H, Chang Y-H, Chiang K-P, Huang Y-T, Lu Y-J. Solar-triggered photothermal therapy for tumor ablation by ag nanoparticles self-precipitated on structural titanium oxide nanofibers. Appl Surf Sci. 2021;552:149428. https://doi.org/10.1016/j.apsusc.2021.149428.10.1016/j.apsusc.2021.149428 ↗
28. Li Z, Zhang H, Han J, Chen Y, Lin H, Yang T. Surface nanopore engineering of 2D MXenes for targeted and synergistic multitherapies of hepatocellular carcinoma. Adv Mater. 2018;30:1706981. https://doi.org/10.1002/adma.201706981.10.1002/adma.201706981 ↗
29. Dai X, Liu D, Pan P, Liang G, Wang X, Chen W. Multifunctional Two-Dimensional Bi2Se3 nanodisks as a Non-Inflammatory photothermal agent for glioma treatment. J Colloid Interface Sci. 2024;661:930–42. https://doi.org/10.1016/j.jcis.2024.01.130.10.1016/j.jcis.2024.01.130 ↗
30. Liu Q, Yang L, Wang L, Li Z, Yu Y, Zheng Y, Lian D, Li X, Chen H, Mei L, Zeng X, Gao N. An injectable hydrogel based on Bi2Se3 nanosheets and hyaluronic acid for chemo-photothermal synergistic therapy. Int J Biol Macromol. 2023;244:125064. https://doi.org/10.1016/j.ijbiomac.2023.125064.10.1016/j.ijbiomac.2023.125064 ↗
31. Singh B, Gautam S, Behera GC, Sahoo UP, Kumar R, Aggarwal V, Tawale JS, Sahoo PK, Ganesan R, Roy SC, Kushvaha SS. Nanostructured Bi2Se3-Decorated TiSe2 pyramids on Ti foil for photoelectrochemical water splitting. ACS Appl Nano Mater. 2024;7:14029–39. https://doi.org/10.1021/acsanm.4c01203.10.1021/acsanm.4c01203 ↗
32. Zhang Y, Zhao W-M, Zhang C, Wang P, Wang T, Li S-C, Xing Z, Xing D. Anomalous superconducting proximity effect in Bi2Se3/FeSe0.5Te0.5 Thin-Film heterojunctions. Adv Mater. 2022;34:2107799. https://doi.org/10.1002/adma.202107799.10.1002/adma.202107799 ↗
33. Pauly C, Rasche B, Koepernik K, Liebmann M, Pratzer M, Richter M, Kellner J, Eschbach M, Kaufmann B, Plucinski L, Schneider Claus M, Ruck M, van den Brink J, Morgenstern M. Subnanometre-wide electron channels protected by topology. Nat Phys. 2015;11:338–43. https://doi.org/10.1038/nphys3264.10.1038/nphys3264 ↗
34. Zong Y, Chen H, Wang J, Wu M, Chen Y, Wang L, Huang X, He H, Ning X, Bai Z, Wen W, Zhu D, Ren X, Wang N, Dou S. Cation Defect-Engineered boost fast kinetics of Two-Dimensional topological Bi2Se3 cathode for High-Performance aqueous Zn-Ion batteries. Adv Mater. 2023;35:2306269. https://doi.org/10.1002/adma.202306269.10.1002/adma.202306269 ↗
35. Wu J-K, Hofmann M, Hsieh W-P, Chen S-H, Yen Z-L, Chiu S-K, Luo Y-R, Chiang C-C, Huang S-Y, Chang Y-H, Hsieh Y-P. Enhancing thermoelectric properties of 2D Bi2Se3 by 1D texturing with graphene. ACS Appl Energy Mater. 2019;2:8411–5. https://doi.org/10.1021/acsaem.9b02122.10.1021/acsaem.9b02122 ↗
36. Buks K, Andzane J, Smits K, Zicans J, Bitenieks J, Zarins A, Erts D. Growth mechanisms and related thermoelectric properties of innovative hybrid networks fabricated by direct deposition of Bi2Se3 and Sb2Te3 on multiwalled carbon nanotubes. Mater Today Energy. 2020;18:100526. https://doi.org/10.1016/j.mtener.2020.100526.10.1016/j.mtener.2020.100526 ↗
37. Klösel K, Pané S, Mihailovic IA, Hierold C. Template-assisted electrosynthesis of Thick stoichiometric thermoelectric Bi2Se3 micropillars. Electrochim Acta. 2022;403:139557. https://doi.org/10.1016/j.electacta.2021.139557.10.1016/j.electacta.2021.139557 ↗
38. Liu Y, Wan H, Mia R, Habib S, Liu H, Mahmud S. Bismuth dichalcogenide-exfoliated Bi2Se3 nanosheets: A novel approach for hexavalent chromium and azo compound photocatalysis. Colloids Surf A. 2024;680:132722. https://doi.org/10.1016/j.colsurfa.2023.132722.10.1016/j.colsurfa.2023.132722 ↗
39. Xiong Y-T, Liu W-X, Tian L, Qin P-L, Chen X-B, Ma L, Liu Q-B, Ding S-J, Wang Q-Q. Broad light absorption and multichannel charge transfer mediated by topological surface state in CdS/ZnS/Bi2Se3 nanotubes for improved photocatalytic hydrogen production. Adv Funct Mater. 2024;2407819. https://doi.org/10.1002/adfm.202407819.10.1002/adfm.202407819 ↗
40. Ibraheem S, Al-Hawary S, Musad Saleh A, Althomali E, Yeslam RH, Shahab HE, Abdulfadhil Gatea S, Alawsi M, Sapaev T I. Efficient photocatalytic reduction of Cr(VI) and degradation of Tetracycline by Bi2Se3@ZnIn2S4 binary heterostructures enriched with sulfur vacancies: mechanism and mineralization analysis. Mater Sci Engineering: B. 2024;305:117387. https://doi.org/10.1016/j.mseb.2024.117387.10.1016/j.mseb.2024.117387 ↗
41. Zhou H, Che L, Guo Z, Wu M, Li W, Xu W, Liu L. Bacteria-Mediated ultrathin Bi2Se3 nanosheets fabrication and their application in photothermal Cancer therapy. ACS Sustain Chem Eng. 2018;6:4863–70. https://doi.org/10.1021/acssuschemeng.7b04321.10.1021/acssuschemeng.7b04321 ↗
42. Mohammadniaei M, Lee T, Bharate BG, Yoon J, Choi HK, Park S-j, Kim J, Kim J, Choi J-W. Bifunctional Au@Bi2Se3 Core–Shell nanoparticle for synergetic therapy by SERS-Traceable AntagomiR delivery and photothermal treatment. Small. 2018;14:1802934. https://doi.org/10.1002/smll.201802934.10.1002/smll.201802934 ↗
43. Xie H, Li Z, Sun Z, Shao J, Yu X-F, Guo Z, Wang J, Xiao Q, Wang H, Wang Q-Q, Zhang H, Chu PK. Metabolizable ultrathin Bi2Se3 nanosheets in Imaging-Guided photothermal therapy. Small. 2016;12:4136–45. https://doi.org/10.1002/smll.201601050.10.1002/smll.201601050 ↗
44. Song G, Liang C, Gong H, Li M, Zheng X, Cheng L, Yang K, Jiang X, Liu Z. Core–Shell mnse@ Bi2Se3 fabricated via a cation exchange method as novel nanotheranostics for multimodal imaging and synergistic thermoradiotherapy. Adv Mater. 2015;27:6110–7. https://doi.org/10.1002/adma.201503006.10.1002/adma.201503006 ↗
45. Liu X-D, Chen B, Wang G-G, Ma S, Cheng L, Liu W, Zhou L, Wang Q-Q. Controlled growth of hierarchical Bi2Se3/CdSe-Au nanorods with optimized photothermal conversion and demonstrations in photothermal therapy. Adv Funct Mater. 2021;31:2104424. https://doi.org/10.1002/adfm.202104424.10.1002/adfm.202104424 ↗
46. Xu Z, Guo X, Yao M, He H, Miao L, Jiao L, Liu H, Wang J, Qian D, Jia J, Ho W, Xie M. Anisotropic topological surface States on High-Index Bi2Se3 films. Adv Mater. 2013;25:1557–62. https://doi.org/10.1002/adma.201202936.10.1002/adma.201202936 ↗
47. Zhang Y, Hu LP, Zhu TJ, Xie J, Zhao XB. High yield Bi2Te3 single crystal nanosheets with uniform morphology via a solvothermal synthesis. Cryst Growth Des. 2013;13:645–51. https://doi.org/10.1021/cg3013156.10.1021/cg3013156 ↗
48. Zhang J, Peng Z, Soni A, Zhao Y, Xiong Y, Peng B, Wang J, Dresselhaus MS, Xiong Q. Raman spectroscopy of Few-Quintuple layer topological insulator Bi2Se3 nanoplatelets. Nano Lett. 2011;11:2407–14. https://doi.org/10.1021/nl200773n.10.1021/nl200773n ↗
49. Wang F, Li L, Huang W, Li L, Jin B, Li H, Zhai T. Submillimeter 2D Bi2Se3 flakes toward High-Performance infrared photodetection at optical communication wavelength. Adv Funct Mater. 2018;28:1802707. https://doi.org/10.1002/adfm.201802707.10.1002/adfm.201802707 ↗
50. Zhou F, Zhao Y, Zhou W, Tang D. Temperature-Dependent Raman scattering of large size hexagonal Bi2Se3 Single-Crystal nanoplates. Appl Sci. 2018;8:1794. https://doi.org/10.3390/app8101794.10.3390/app8101794 ↗