Curcumin-functionalized Prussian blue for NIR-II photothermal antibacterial therapy
Source abstract
Abstract
FDA-approved Prussian blue (PB) has been developed as a nano photothermal therapy (PTT) agent due to its unique FeIII-CN-FeII structure and the resulting near-infrared (NIR) absorption performance. Nevertheless, the NIR absorption peaks of traditional PB-based nanomedicines are often located in the NIR-I region (700-900 nm) rather than NIR-II region (900-1700 nm), thus limiting their efficacy in treating deep lesions. Herein, curcumin (Cur)-functionalized PB nanomedicine is elaborately designed for NIR-II PTT against bacterial infections. In addition to serving as a dispersant and a reducing agent, the introduced Cur effectively regulates the absorption peak of PB to the NIR-II region. Moreover, as-prepared Cur-functionalized PB nanomedicine demonstrated superior photothermal antibacterial performance against S. aureus. Therefore, this study proffers a new attempt centered on the optical performance regulation of PB and lays the foundation for next-generation PTT nanomedicines.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Curcumin's Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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