Graphitic carbon nitride for biomedical applications: challenges and future opportunities in dentistry
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Abstract
Abstract Graphitic carbon nitride (g-C 3 N 4 ) is an emerging nanomaterial with unique features such as photocatalyst, biocompatibility, and tunable surface chemistry, placing g-C₃N₄ as a versatile platform for innovative biomedical applications. This review explores the properties, synthesis, biomedical applications, challenges, and future perspectives of g-C₃N₄. An electronic search of PubMed and Elsevier’s Scopus was undertaken, with no limits to the year of publication, and only English-language literature was included. One of the notable applications is as a drug delivery system due to its large surface area, functional tunability, and controlled release mechanisms. Recently, g-C 3 N 4 has also emerged as a promising agent for cancer treatment, particularly in photodynamic and photothermal therapies. Another widely explored application is its role in regenerative medicine, including wound healing, where its biocompatibility and ability to enhance cellular interactions are advantageous. Additionally, g-C 3 N 4 demonstrates strong potential in biosensing and bioimaging, leveraging its fluorescence properties for diagnostic and monitoring applications. While direct studies in dentistry are limited, these biomedical advancements suggest a potential for future dental applications, particularly in antimicrobial coatings, drug-loaded restorative materials, and guided tissue regeneration. Future research should focus on optimizing g-C 3 N 4 -based materials for targeted clinical applications, particularly within dentistry.
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OpenAlex topics: Advanced Photocatalysis Techniques · Graphene and Nanomaterials Applications · Carbon and Quantum Dots Applications
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References (100+)
Show source-provided references
1. Wang X, Chen X, Thomas A, Fu X, Antonietti M. Metal-containing carbon nitride compounds: a new functional organic–metal hybrid material. Adv Mater. 2009;21:1609–12. https://doi.org/10.1002/adma.200802627.10.1002/adma.200802627 ↗
2. Liebig J. Uber einige Stickstoff-Verbindungen. Annalen der Pharmacie. 1834;10:1–47.10.1002/jlac.18340100102 ↗
3. Franklin EC. The ammono carbonic acids. J Am Chem Soc. 1922;44:486–509.10.1021/ja01424a007 ↗
4. Pauling L, Sturdivant J. The structure of cyameluric acid, hydromelonic acid and related substances. Proc Natl Acad Sci. 1937;23:615–20.10.1073/pnas.23.12.615 ↗
5. Kumru B, Antonietti M. Colloidal properties of the metal-free semiconductor graphitic carbon nitride. Adv Opt Mater. 2020;283:102229. https://doi.org/10.1016/j.cis.2020.102229.10.1016/j.cis.2020.102229 ↗
6. Zhu J, Xiao P, Li H, Carabineiro SA. Graphitic carbon nitride: synthesis, properties, and applications in catalysis. ACS Appl Mater Interfaces. 2014;6:16449–65.10.1021/am502925j ↗
7. Deshmukh S, Pawar K, Koli V, Pachfule P. Emerging graphitic carbon nitride-based nanobiomaterials for biological applications. ACS Appl Bio Mater. 2023;6:1339–67. https://doi.org/10.1021/acsabm.2c01016.10.1021/acsabm.2c01016 ↗
8. Zhao C, Zhou B. Polyethyleneimine-based drug delivery systems for cancer theranostics. J Funct Biomater. 2022. https://doi.org/10.3390/jfb14010012.10.3390/jfb14010012 ↗
9. Sun J, Shi F, Lu Q, Ye W, Liu S, et al. On-demand release of CO in dual-responsive nanocomposite hydrogels for wound dressing. Surf Interfaces. 2024;54:105133. https://doi.org/10.1016/j.surfin.2024.105133.10.1016/j.surfin.2024.105133 ↗
10. Malik US, Duan Q, Niazi MBK, Jahan Z, Liaqat U, et al. Vanillin cross-linked hydrogel membranes interfacial reinforced by carbon nitride nanosheets for enhanced antibacterial activity and mechanical properties. Chin Chem Lett. 2023;34:108071. https://doi.org/10.1016/j.cclet.2022.108071.10.1016/j.cclet.2022.108071 ↗
11. Zaboli A, Raissi H, Farzad F. Molecular interpretation of the carbon nitride performance as a template for the transport of anti-cancer drug into the biological membrane. Sci Rep. 2021;11:18981. https://doi.org/10.1038/s41598-021-98597-2.10.1038/s41598-021-98597-2 ↗
12. Perveen M, Nazir S, Arshad AW, Khan MI, Shamim M, et al. Therapeutic potential of graphitic carbon nitride as a drug delivery system for cisplatin (anticancer drug): a DFT approach. Biophys Chem. 2020;267:106461. https://doi.org/10.1016/j.bpc.2020.106461.10.1016/j.bpc.2020.106461 ↗
13. Nawaz A, Taj MB, Carabineiro SAC. Graphitic carbon nitride as an efficient carrier for anti-cancer drug systems: a review. Next Nanotechnol. 2024;6:100074. https://doi.org/10.1016/j.nxnano.2024.100074.10.1016/j.nxnano.2024.100074 ↗
14. Perveen M, Aslam F, Nazir S, Khan MI, Zahra G, et al. DFT study of therapeutic potential of graphitic carbon nitride as a carrier for controlled release of melphalan: an anticancer drug. J Mol Model. 2022;28:359. https://doi.org/10.1007/s00894-022-05337-y.10.1007/s00894-022-05337-y ↗
15. Wang Y, Wu S, Shen J, Huang J, Wang C, et al. Ca-doping interfacial engineering and glycolysis enable rapid charge separation for efficient phototherapy of MRSA-infected wounds. Acta Biomater. 2024;179:284–99. https://doi.org/10.1016/j.actbio.2024.03.010.10.1016/j.actbio.2024.03.010 ↗
16. Awasthi GP, Kaliannagounder VK, Park J, Maharjan B, Shin M, et al. Assembly of porous graphitic carbon nitride nanosheets into electrospun polycaprolactone nanofibers for bone tissue engineering. Colloids Surf A: Physicochem Eng Asp. 2021;622:126584. https://doi.org/10.1016/j.colsurfa.2021.126584.10.1016/j.colsurfa.2021.126584 ↗
17. Liu Y, Zhou A, Zhang Y, Tian Z, Cheng X, et al. A photoactive self-healing carboxymethyl chitosan-based hydrogel for accelerated infected wound healing through simultaneously modulating multiple critical tissue repair factors. Int J Biol Macromol. 2023;242:124631.10.1016/j.ijbiomac.2023.124631 ↗
18. Arumugam G, Durairaj S, Gonçale JC, Fonseca do Carmo PH, Terra Garcia M, et al. Silver nanoparticle-embedded carbon nitride: antifungal activity on candida albicans and toxicity toward animal cells. ACS Appl Mater Interfaces. 2024;16:25727–39. https://doi.org/10.1021/acsami.4c02694.10.1021/acsami.4c02694 ↗
19. Xiang MH, Liu JW, Li N, Tang H, Yu RQ, et al. A fluorescent graphitic carbon nitride nanosheet biosensor for highly sensitive, label-free detection of alkaline phosphatase. Nanoscale. 2016;8:4727–32. https://doi.org/10.1039/c5nr08278a.10.1039/c5nr08278a ↗
20. Wang Y, Jiang X, Cao W, Wang H, Yuan R. N vacancy and self-enhancement induced high anodic electrochemiluminescence of 3D g-C3N4 for sensitive staphylococcus aureus analysis. Talanta. 2024;275:126144. https://doi.org/10.1016/j.talanta.2024.126144.10.1016/j.talanta.2024.126144 ↗
21. Wang X, Qin L, Lin M, Xing H, Wei H. Fluorescent graphitic carbon nitride-based nanozymes with peroxidase-like activities for ratiometric biosensing. Anal Chem. 2019;91:10648–56. https://doi.org/10.1021/acs.analchem.9b01884.10.1021/acs.analchem.9b01884 ↗
22. Tian F, Lyu J, Shi J, Yang M. Graphene and graphene-like two-denominational materials based fluorescence resonance energy transfer (FRET) assays for biological applications. Biosens Bioelectron. 2017;89:123–35. https://doi.org/10.1016/j.bios.2016.06.046.10.1016/j.bios.2016.06.046 ↗
23. Rana A, Killa M, Yadav N, Mishra A, Mathur A, et al. Graphitic carbon nitride as an amplification platform on an electrochemical paper-based device for the detection of norovirus-specific DNA. Sens (Basel). 2020;20:2070. https://doi.org/10.3390/s20072070.10.3390/s20072070 ↗
24. Gross EM, Maddipati SS, Snyder SM. A review of electrogenerated chemiluminescent biosensors for assays in biological matrices. Bioanalysis. 2016;8:2071–89. https://doi.org/10.4155/bio-2016-0178.10.4155/bio-2016-0178 ↗
25. Tan G-R, Wang M, Hsu C-Y, Chen N, Zhang Y. Small upconverting fluorescent nanoparticles for biosensing and bioimaging. Adv Opt Mater. 2016;4:984–97. https://doi.org/10.1002/adom.201600141.10.1002/adom.201600141 ↗
26. Rosa V, Cavalcanti BN, Nör JE, Tezvergil-Mutluay A, Silikas N, et al. Guidance for evaluating biomaterials’ properties and biological potential for dental pulp tissue engineering and regeneration research. Dent Mater. 2025;41:248–64. https://doi.org/10.1016/j.dental.2024.12.003.10.1016/j.dental.2024.12.003 ↗
27. Matoug-Elwerfelli M, Nazzal H, Duggal M, El-Gendy R. What the future holds for regenerative endodontics: novel antimicrobials and regenerative strategies. Eur Cell Mater. 2021;41:811–33. https://doi.org/10.22203/eCM.v041a51.10.22203/eCM.v041a51 ↗
28. Miller T, Jorge AB, Suter T, Sella A, Corà F, et al. Carbon nitrides: synthesis and characterization of a new class of functional materials. Phys Chem Chem Phys. 2017;19:15613–38.10.1039/C7CP02711G ↗
29. Cao S, Huang Q, Zhu B, Yu J. Trace-level phosphorus and sodium co-doping of g-C3N4 for enhanced photocatalytic H2 production. J Power Sources. 2017;351:151–59.10.1016/j.jpowsour.2017.03.089 ↗
30. Chemistry Manufacturing and Controls. (CMC) guidances for industry (GFIs) and questions and answers (Q&As) [Available from: https://www.fda.gov/animal-veterinary/guidance-industry/chemistry-manufacturing-and-controls-cmc-guidances-industry-gfis-and-questions-and-answers-qas
31. Qi K, Liu S-y, Zada A. Graphitic carbon nitride, a polymer photocatalyst. J Taiwan Inst Chem Eng. 2020;109:111–23.10.1016/j.jtice.2020.02.012 ↗
32. Liu X, Kang W, Zeng W, Zhang Y, Qi L, et al. Structural, electronic and photocatalytic properties of g-C3N4 with intrinsic defects: a first-principles hybrid functional investigation. Appl Surf Sci. 2020;499:143994. https://doi.org/10.1016/j.apsusc.2019.143994.10.1016/j.apsusc.2019.143994 ↗
33. Soni S, Teli S, Teli P, Agarwal S. Empowering sustainability: Charting the seven years of progress in g-C₃N₄ based materials and their crucial role in building a greener future. Sustain Chem Pharm. 2024;41:101693. https://doi.org/10.1016/j.scp.2024.101693.10.1016/j.scp.2024.101693 ↗
34. Zhao G, Huang X, Wang X, Wang X. Progress in catalyst exploration for heterogeneous CO2 reduction and utilization: a critical review. J Mater Chem A. 2017;5:21625–49. https://doi.org/10.1039/c7ta07290b.10.1039/c7ta07290b ↗
35. Wen J, Xie J, Chen X, Li X. A review on g-C3N4-based photocatalysts. Appl Surf Sci. 2017;391:72–123. https://doi.org/10.1016/j.apsusc.2016.07.030.10.1016/j.apsusc.2016.07.030 ↗
36. Ong WJ, Tan LL, Ng YH, Yong ST, Chai SP. Graphitic carbon nitride (g-C3N4)-based photocatalysts for artificial photosynthesis and environmental remediation: Are We a step closer to achieving sustainability? Chem Rev. 2016;116:7159–329. https://doi.org/10.1021/acs.chemrev.6b00075.10.1021/acs.chemrev.6b00075 ↗
37. Wang Y, Wang X, Antonietti M. Polymeric graphitic carbon nitride as a heterogeneous organocatalyst: from photochemistry to multipurpose catalysis to sustainable chemistry. Angew Chem Int Ed. 2012;51:68–89. https://doi.org/10.1002/anie.201101182.10.1002/anie.201101182 ↗
38. Zhang J, Zhang M, Sun RQ, Wang X. A facile band alignment of polymeric carbon nitride semiconductors to construct isotype heterojunctions. Angew Chem. 2012;124:10292–96.10.1002/ange.201205333 ↗
39. Chen Y, Lu C. Graphitic carbon nitride nanomaterials for high-performance supercapacitors. Carbon neutraliz. 2023;2:585–602. https://doi.org/10.1002/cnl2.87.10.1002/cnl2.87 ↗
40. Eid K, Gamal A, Abdullah AM. Graphitic carbon nitride-based nanostructures as emergent catalysts for carbon monoxide (CO) oxidation. Green Chem. 2023;25:1276–310.10.1039/D2GC02748H ↗
41. Wang Q, Li Y, Huang F, Song S, Ai G, et al. Recent advances in g-C3N4-based materials and their application in energy and environmental sustainability. Molecules. 2023;28:432. https://doi.org/10.3390/molecules28010432.10.3390/molecules28010432 ↗
42. Ismael M, Wu Y, Taffa DH, Bottke P, Wark M. Graphitic carbon nitride synthesized by simple pyrolysis: role of precursor in photocatalytic hydrogen production. New J Chem. 2019;43:6909–20.10.1039/C9NJ00859D ↗
43. Mou H, Wang J, Yu D, Zhang D, Chen W, et al. Fabricating amorphous g-C3N4/ZrO2 photocatalysts by one-step pyrolysis for solar-driven ambient ammonia synthesis. ACS Appl Mater Interfaces. 2019;11:44360–65.10.1021/acsami.9b16432 ↗
44. Zhang H, Li W, Yan Y, Wang W, Ren Y, et al. Synthesis of highly porous g-C3N4 nanotubes for efficient photocatalytic degradation of sulfamethoxazole. Mater Today Commun. 2021;27:102288.10.1016/j.mtcomm.2021.102288 ↗
45. Mukhopadhyay TK, Leherte L, Datta A. Molecular mechanism for the self-supported synthesis of graphitic carbon nitride from urea pyrolysis. J Phys Chem Lett. 2021;12:1396–406.10.1021/acs.jpclett.0c03559 ↗
46. Lei L, Fan H, Jia Y, Wang W. Control of carbon vacancies in g-C3N4 photocatalyst via wood pyrolysis induced etching strategy. Appl Surf Sci. 2023;639:158259.10.1016/j.apsusc.2023.158259 ↗
47. Joy J, George E, Vijayan PP, Anas S, Thomas S. An overview of synthesis, morphology, and versatile applications of nanostructured graphitic carbon nitride (g-C3N4). J Ind Eng Chem. 2024;133:74–89.10.1016/j.jiec.2023.12.016 ↗
48. Pei J, Li H, Zhuang S, Zhang D, Yu D. Recent advances in g-C3N4 photocatalysts: a review of reaction parameters, structure design and exfoliation methods. Catalysts. 2023;13:1402.10.3390/catal13111402 ↗
49. Medina-Llamas M, Bianchi E, Mozzati MC, Tedesco C, Milanese C, et al. Synthesis of carbon nitride polymorphs by sacrificial template method: correlation between physicochemical properties and photocatalytic performance. Chemsuschem. 2024;18:e202400918.10.1002/cssc.202400918 ↗
50. Wenyu C, Chengbao L, Leizhi Z, Feng C, Junchao Q, et al. Template-induced synthesis of MnO2-g-C3N4/C three-phase composites and its performance for supercapacitors. Chem Phys Lett. 2024;849:141422.10.1016/j.cplett.2024.141422 ↗
51. AbouSeada N, Elmahgary MG, Abdellatif SO, Kirah K. Synergistic integration of zirconium-based metal-organic frameworks and graphitic carbon nitride for sustainable energy solutions: a comprehensive review. J Alloys Compd. 2024;1002:175325. https://doi.org/10.1016/j.jallcom.2024.175325.10.1016/j.jallcom.2024.175325 ↗
52. Janardhana D, Jayaramu SN, Coetsee E, Motaung DE, Swart HC. Nanosheet g-C3N4 decorated α-Bi2O3: Eu3 + needles for efficient photocatalytic degradation of rhodamine B dye. Mater Sci Semicond. 2024;184:108789.10.1016/j.mssp.2024.108789 ↗
53. Chen I-T, Zheng M-W, Liu S-H. Microwave-assisted hydrothermal synthesis of mesoporous three-dimensional hexagonal graphitic carbon nitride for selective CO2 photoreduction. J Photochem Photobiol Chem. 2022;433:114199.10.1016/j.jphotochem.2022.114199 ↗
54. Matias ML, Reis-Machado AS, Rodrigues J, Calmeiro T, Deuermeier J, et al. Microwave synthesis of visible-light-activated g-C3N4/TiO2 photocatalysts. Nanomaterials (Basel). 2023;13:1090.10.3390/nano13061090 ↗
55. Saxena M, Sharma AK, Srivastava AK, Dixit AR, Singh N, et al. Microwave-assisted vs. conventional hydrothermal synthesis, morphology, microstructure, and surface area analysis of g-C3N4/MoS2 nanocomposite. Characterization, and processing of smart materials: IGI global: modeling; 2023. pp. 151–64.10.4018/978-1-6684-9224-6.ch007 ↗
56. Venkatesh D, Deepthi G, Mangatayaru KG, Noorjahan M. Microwave-assisted synthesis, characterization, photocatalytic degradation of antibiotics, and fluorometric selective sensing activity of g-C3N4 supported CuO composites. J Fluoresc. 2023;33:987–1002.10.1007/s10895-022-03125-8 ↗
57. Li R, Qu J, Zhang Y, Liang X, Li Y, et al. One-pot microwave synthesize bandgap tunable g-C3N4 for highly efficient photocatalytic H2O2 production. Mater Sci Semicond. 2024;179:108520.10.1016/j.mssp.2024.108520 ↗
58. Bian Z, Gomez E, Gruebele M, Levine BG, Link S, et al. Bottom-up carbon dots: purification, single-particle dynamics, and electronic structure. Chem Sci. 2025;16:4195–212. https://doi.org/10.1039/d4sc05843g.10.1039/d4sc05843g ↗
59. Narayanan N, Mohanprasanth A, Thirumalaivasan N. Fluorescence-guided chitosan and eugenol-based carbon dots for comprehensive infection control and in vitro wound-healing applications in dentistry. Dentistry J. 2026;14:133. https://doi.org/10.3390/dj14030133.10.3390/dj14030133 ↗
60. Kanagaraj K, Nangan S, Thirumalaivasan N. Carbon dots and their role in cancer immunotherapy: targeted drug delivery and tumor microenvironment modulation-a narrative review. Next Mater. 2026;11:101711. https://doi.org/10.1016/j.nxmate.2026.101711.10.1016/j.nxmate.2026.101711 ↗
61. Rajabzadeh-Khosroshahi M, Pourmadadi M, Yazdian F, Rashedi H, Navaei-Nigjeh M, et al. Chitosan/agarose/graphitic carbon nitride nanocomposite as an efficient pH-sensitive drug delivery system for anticancer curcumin releasing. J Drug Deliv Sci Technol. 2022;74:103443. https://doi.org/10.1016/j.jddst.2022.103443.10.1016/j.jddst.2022.103443 ↗
62. Abdouss H, Pourmadadi M, Zahedi P, Abdouss M, Yazdian F, et al. Green synthesis of chitosan/polyacrylic acid/graphitic carbon nitride nanocarrier as a potential pH-sensitive system for curcumin delivery to MCF-7 breast cancer cells. Int J Biol Macromol. 2023;242:125134. https://doi.org/10.1016/j.ijbiomac.2023.125134.10.1016/j.ijbiomac.2023.125134 ↗
63. Zhao Z, Sun Y, Dong F. Graphitic carbon nitride based nanocomposites: a review. Nanoscale. 2015;7:15–37. https://doi.org/10.1039/c4nr03008g.10.1039/c4nr03008g ↗
64. Alomari RA, Athinarayanan J, Periasamy VS, Alharbi L, Alshatwi AA. Synthesis of folic acid loaded g-C3N4/Ag2S nanohybrids for near infrared light mediated photothermal ablation of breast cancer cells. Diam Relat Mater. 2023;135:109785. https://doi.org/10.1016/j.diamond.2023.109785.10.1016/j.diamond.2023.109785 ↗
65. Wang Q, Ji Y, Shi J, Wang L, NIR-driven water. Splitting H2 production nanoplatform for H2-mediated cascade-amplifying synergetic cancer therapy. ACS Appl Mater Interfaces. 2020;12:23677–88. https://doi.org/10.1021/acsami.0c03852.10.1021/acsami.0c03852 ↗
66. Ilyas M, Khan MA, Kalsoom S, Abbas M, Perveen M, et al. Exploring graphitic carbon nitride as novel drug delivery system for hesperetin (anticancer drug): insights from DFT calculations and molecular dynamics simulations. Int J Quantum Chem. 2025;125:e70018. https://doi.org/10.1002/qua.70018.10.1002/qua.70018 ↗
67. Pourmadadi M, Rahmani E, Eshaghi MM, Shamsabadipour A, Ghotekar S, et al. Graphitic carbon nitride (g-C3N4) synthesis methods, surface functionalization, and drug delivery applications: a review. J Drug Deliv Sci Technol. 2023;79:104001. https://doi.org/10.1016/j.jddst.2022.104001.10.1016/j.jddst.2022.104001 ↗
68. Khoshtabiat L, Meshkini A, Matin MM. g-C3N4-based photoresponsive magnetic nanocatalyst drives type-I photodynamic therapy under visible light irradiation, boosting chemo/chemodynamic synergistic therapy of colon cancer. Cancer Nanotechnol. 2023;14:40. https://doi.org/10.1186/s12645-023-00188-5.10.1186/s12645-023-00188-5 ↗
69. Chen R, Zhang J, Wang Y, Chen X, Zapien JA, et al. Graphitic carbon nitride nanosheet@metal–organic framework core–shell nanoparticles for photo-chemo combination therapy. Nanoscale. 2015;7:17299–305. https://doi.org/10.1039/C5NR04436G.10.1039/C5NR04436G ↗
70. Alshawwa SZ, Kassem AA, Farid RM, Mostafa SK, Labib GS. Nanocarrier drug delivery systems: characterization, limitations, future perspectives and implementation of artificial intelligence. Pharmaceutics. 2022;14:883. https://doi.org/10.3390/pharmaceutics14040883.10.3390/pharmaceutics14040883 ↗
71. Chang Y, Xu K-Q, Yang X-L, Xie M-H, Mo Z et al. Zinc hexacyanoferrate/g-C3N4 nanocomposites with enhanced photothermal and photodynamic properties for rapid sterilization and wound healing. Colloids Surf B Biointerfaces. 2024;240:113998.10.1016/j.colsurfb.2024.113998 ↗
72. Sabzini M, Pourmadadi M, Yazdian F, Khadiv-Parsi P, Rashedi H. Development of chitosan/halloysite/graphitic–carbon nitride nanovehicle for targeted delivery of quercetin to enhance its limitation in cancer therapy: an in vitro cytotoxicity against MCF-7 cells. Int J Biol Macromol. 2023;226:159–71. https://doi.org/10.1016/j.ijbiomac.2022.11.189.10.1016/j.ijbiomac.2022.11.189 ↗
73. Habibi Jouybari M, Hosseini S, Mahboobnia K, Boloursaz LA, Moradi M, et al. Simultaneous controlled release of 5-FU, DOX and PTX from chitosan/PLA/5-FU/g-C3N4-DOX/g-C3N4-PTX triaxial nanofibers for breast cancer treatment in vitro. Colloids Surf B Biointerfaces. 2019;179:495–504. https://doi.org/10.1016/j.colsurfb.2019.04.026.10.1016/j.colsurfb.2019.04.026 ↗
74. Alaghmandfard A, Ghandi K. A comprehensive review of graphitic carbon nitride (g-C3N4)-metal oxide-based nanocomposites: potential for photocatalysis and sensing. Nanomaterials (Basel). 2022;12:294. https://doi.org/10.3390/nano12020294.10.3390/nano12020294 ↗
75. Liu C, Qin H, Kang L, Chen Z, Wang H, et al. Graphitic carbon nitride nanosheets as a multifunctional nanoplatform for photochemical internalization-enhanced photodynamic therapy. J Mater Chem B. 2018;6:7908–15. https://doi.org/10.1039/c8tb02535e.10.1039/c8tb02535e ↗
76. Muthiah KS, Thirumurugan S, Lin Y-C, Sakthivel R, Dhawan U, et al. Cerium niobate hollow sphere engineered graphitic carbon nitride for synergistic photothermal/chemodynamic cancer therapy. Crystals. 2023;13:954.10.3390/cryst13060954 ↗
77. Sun D, Zhang Z, Chen M, Zhang Y, Amagat J, et al. Co-immobilization of Ce6 Sono/photosensitizer and protonated graphitic carbon nitride on PCL/gelation fibrous scaffolds for combined sono-photodynamic cancer therapy. ACS Appl Mater Interfaces. 2020;12:40728–39. https://doi.org/10.1021/acsami.0c08446.10.1021/acsami.0c08446 ↗
78. Ju E, Dong K, Chen Z, Liu Z, Liu C, et al. Copper(II)-graphitic carbon nitride triggered synergy: improved ROS generation and reduced glutathione levels for enhanced photodynamic therapy. Angew Chem Int Ed Engl. 2016;55:11467–71. https://doi.org/10.1002/anie.201605509.10.1002/anie.201605509 ↗
79. Liu H, Lv X, Qian J, Li H, Qian Y, et al. Graphitic carbon nitride quantum dots embedded in carbon nanosheets for near-infrared imaging-guided combined photo-chemotherapy. ACS Nano. 2020;14:13304–15. https://doi.org/10.1021/acsnano.0c05143.10.1021/acsnano.0c05143 ↗
80. Chan MH, Liu RS, Hsiao M. Graphitic carbon nitride-based nanocomposites and their biological applications: a review. Nanoscale. 2019;11:14993–5003. https://doi.org/10.1039/c9nr04568f.10.1039/c9nr04568f ↗
81. Zheng DW, Li B, Li CX, Fan JX, Lei Q, et al. Carbon-dot-decorated carbon nitride nanoparticles for enhanced photodynamic therapy against hypoxic tumor via water splitting. ACS Nano. 2016;10:8715–22. https://doi.org/10.1021/acsnano.6b04156.10.1021/acsnano.6b04156 ↗
82. Li M, Xiao M, Pan Q, Xiong J. Multifunctional nanoplatform based on g-C3N4, loaded with MnO2 and CuS nanoparticals for oxygen self-generation photodynamic/photothermal synergistic therapy. Photodiagnosis Photodyn Ther. 2022;37:102684. https://doi.org/10.1016/j.pdpdt.2021.102684.10.1016/j.pdpdt.2021.102684 ↗
83. Wang Y, Xia L, Wei C, Wang H, Wang H, et al. Ultrasensitive photoelectrochemical microRNA biosensor based on doxorubicin sensitized graphitic carbon nitride assisted by a target-activated enzyme-free DNA walker. Chem Commun. 2019;55:13082–84. https://doi.org/10.1039/C9CC06556C.10.1039/C9CC06556C ↗
84. Wang H, Lin Q, Yin L, Yang Y, Qiu Y, et al. Biomimetic design of hollow flower-like g-C3N4@PDA organic framework nanospheres for realizing an efficient photoreactivity. Small. 2019;15:e1900011. https://doi.org/10.1002/smll.201900011.10.1002/smll.201900011 ↗
85. Gu BJ, Park SY, Kim W, Garcia-Godoy F, Kwon YH. g-C3N4-based complexes for treating in vitro oral cancer cells. Am J Dent. 2025;38:319–22.
86. Liu C, Qin H, Kang L, Chen Z, Wang H, et al. Graphitic carbon nitride nanosheets as a multifunctional nanoplatform for photochemical internalization-enhanced photodynamic therapy. J Mater Chem B. 2018;6:7908–15. https://doi.org/10.1039/C8TB02535E.10.1039/C8TB02535E ↗
87. Wu X, Yang L, Luo L, Shi G, Wei X, et al. Engineered g-C3N4 quantum dots for tunable two-photon imaging and photodynamic therapy. ACS Appl Bio Mater. 2019;2:1998–2005.10.1021/acsabm.9b00055 ↗
88. Sorourian M, Pourmadadi M, Yazdian F, Rashedi H, Nigjeh MN, et al. Engineered bacterial cellulose-based Ag nanoparticles/g-C3N4/Eucalyptus extract nanocomposites for wound dressing: In vitro evaluation. Eur J Med Chem. 2024;12:100190. https://doi.org/10.1016/j.ejmcr.2024.100190.10.1016/j.ejmcr.2024.100190 ↗
89. Papaioannou A, Vasilaki E, Loukelis K, Papadogianni D, Chatzinikolaidou M, et al. Bioactive and biomimetic 3D scaffolds for bone tissue engineering using graphitic carbon nitride as a sustainable visible light photoinitiator. Biomater Adv. 2024;157:213737. https://doi.org/10.1016/j.bioadv.2023.213737.10.1016/j.bioadv.2023.213737 ↗
90. Dutta SD, Hexiu J, Moniruzzaman M, Patil TV, Acharya R, et al. Tailoring osteoimmunity and hemostasis using 3D-Printed nano-photocatalytic bactericidal scaffold for augmented bone regeneration. Biomaterials. 2025;316:122991. https://doi.org/10.1016/j.biomaterials.2024.122991.10.1016/j.biomaterials.2024.122991 ↗
91. Zhang Z, Jørgensen ML, Wang Z, Amagat J, Wang Y, et al. 3D anisotropic photocatalytic architectures as bioactive nerve guidance conduits for peripheral neural regeneration. Biomaterials. 2020;253:120108. https://doi.org/10.1016/j.biomaterials.2020.120108.10.1016/j.biomaterials.2020.120108 ↗
92. Jiawen G, Xing W. Carbon nitride nanocomposites for periodontitis targeted antibacterial and osteogenesis. Int Dent J. 2025;75:104670.10.1016/j.identj.2025.104670 ↗
93. Paltinean GA, Moldovan M, Sarosi C, Silaghi-Dumitrescu L, Cuc S, et al. Graphitic carbon nitride in oral health: emerging applications, antimicrobial potential, and future perspectives. Int J Mol Sci. 2025;26:11860. https://doi.org/10.3390/ijms262411860.10.3390/ijms262411860 ↗
94. Swetha K, Bhatnagar A, Lakavathu M, Poornima P, Ganesh P, et al. Biological degradation of graphitic carbon nitride sheets and autophagy induction in macrophages. Nanoscale. 2025;17:15267–78. https://doi.org/10.1039/d5nr00795j.10.1039/d5nr00795j ↗
95. Sadek AA, Abd-Elkareem M, Abdelhamid HN, Moustafa S, Hussein K. Repair of critical-sized bone defects in rabbit femurs using graphitic carbon nitride (g-C3N4) and graphene oxide (GO) nanomaterials. Sci Rep. 2023;13:5404. https://doi.org/10.1038/s41598-023-32487-7.10.1038/s41598-023-32487-7 ↗
96. Jeirani Khamene A, Yazdian F, Pourmadadi M, Ghobeh M, Khoshmaram K, et al. Fabrication and characterization of an innovative g-C3N4/calcium/aloe vera enriched PVA-bacterial cellulose wound dressing: a novel approach to diabetic wound management. Inorg Chem Commun. 2024;168:112879. https://doi.org/10.1016/j.inoche.2024.112879.10.1016/j.inoche.2024.112879 ↗
97. Pan T, Zhang Y, Qu X, Liang X, Zhao Y. AgNPs/g-C3N4/PVA antibacterial hydrogel with excellent photocatalytic antibacterial activity for wound dressing. New J Chem. 2024;48:7785–98. https://doi.org/10.1039/D4NJ00582A.10.1039/D4NJ00582A ↗
98. Huang J, Wu S, Wang Y, Shen J, Wang C, et al. Dual elemental doping activated signaling pathway of angiogenesis and defective heterojunction engineering for effective therapy of MRSA-infected wounds. Bioact Mater. 2024;37:14–29. https://doi.org/10.1016/j.bioactmat.2024.03.011.10.1016/j.bioactmat.2024.03.011 ↗
99. He B, Zhao W, Li W, Wei C, Sun J. Ionic liquids microenvironment modulates the interface properties of g-C3N4 for boosting the performance of photodegradation and infected wound-healing therapy. Small Methods. 2024;8:2301378. https://doi.org/10.1002/smtd.202301378.10.1002/smtd.202301378 ↗
100. Lei R, Gu M, Li J, Wang W, Yu Q, et al. Lipoic acid/trometamol assembled hydrogel as injectable bandage for hypoxic wound healing at high altitude. Chem Eng J. 2024;489:151499. https://doi.org/10.1016/j.cej.2024.151499.10.1016/j.cej.2024.151499 ↗