journal article·2025-06-18Open access

2009–2023 Bibliometric analysis of the clinical value of graphene quantum dots in glioblastoma treatment

Jingyan Zhu, Xiaoqing Li, Zhenhua Lin, Linzhuo Qu, Hongjian Guan

Discover Nano· Volume 20· Issue 1

Abstract

Glioblastoma (GBM) is the most common primary brain tumour in adults and poses a serious health risk. Graphene quantum dots (GQDs) are zero-dimensional crystalline discs de-rived from two-dimensional graphene, which contribution of GQDs in the treatment of GBM and the great potential for future development. In this study, the Web of Science database was applied to search 462 relevant papers published between 2009 and 2023, and analyzed using VOS viewer and CiteSpace software tools. This analysis aims to provide researchers with insights into the current state of applications and to facilitate a clearer understanding of potential pathways and directions for future research in this field. Our study showed a continuous increase in the number of papers about GQDs in the treatment of GBM. In the field for more than a decade, GQDs has been a research priority in drug delivery due to their excellent optical and chemical properties. It is reasonable to believe that the use of GQDs for drug delivery for the treatment of GBM will be-come one of the extremely important research topics in the future.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Graphene and Nanomaterials Applications · Carbon and Quantum Dots Applications · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (19)

Show source-provided references
1. Barzegar Behrooz A, Talaie Z, Syahir A. Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable. Pharmaceutics. 2022;14(8):1697.10.3390/pharmaceutics14081697 ↗
2. Karschnia P, Young JS, Dono A, Häni L, Sciortino T, Bruno F, Juenger ST, Teske N, Morshed RA, Haddad AF, Zhang Y, Stoecklein S, Weller M, Vogelbaum MA, Beck J, Tandon N, Hervey-Jumper S, Molinaro AM, Rudà R, Bello L, Schnell O, Esquenazi Y, Ruge MI, Grau SJ, Berger MS, Chang SM, van den Bent M, Tonn JC. Prognostic validation of a new classification system for extent of resection in glioblastoma: a report of the RANO resect group. Neuro Oncol. 2023;25(5):940–54.10.1093/neuonc/noac193 ↗
3. Nguyen TT, Dung Nguyen TT, Vo TK, Tran NM, Nguyen MK, Van Vo T, Van Vo G. Nanotechnology-based drug delivery for central nervous system disorders. Biomed Pharmacother. 2021;143: 112117.10.1016/j.biopha.2021.112117 ↗
4. Iannazzo D, Celesti C, Giofrè SV, Ettari R, Bitto A. Theranostic applications of 2D graphene-based materials for solid tumors treatment. Nanomaterials. 2023;13(16):2380.10.3390/nano13162380 ↗
5. Guo W, Song X, Liu J, Liu W, Chu X, Lei Z. Quantum dots as a potential multifunctional material for the enhancement of clinical diagnosis strategies and cancer treatments. Nanomaterials. 2024;14(13):1088.10.3390/nano14131088 ↗
6. Wang J, Maniruzzaman M. A global bibliometric and visualized analysis of bacteria-mediated cancer therapy. Drug Discov Today. 2022;27(10): 103297.10.1016/j.drudis.2022.05.023 ↗
7. Liu C, Deng C, Li Z, Liu Y, Wang S. Optimization of spatial pattern of land use: progress, frontiers, and prospects. Int J Environ Res Public Health. 2022;19(10):5805.10.3390/ijerph19105805 ↗
8. Xia Y, Yao RQ, Zhao PY, Tao ZB, Zheng LY, Zhou HT, Yao YM, Song XM. Publication trends of research on COVID-19 and host immune response: a bibliometric analysis. Front Public Health. 2022;8(10): 939053.10.3389/fpubh.2022.939053 ↗
9. Ling LX, Ouyang Y, Hu Y. Research trends on nanomaterials in gastric cancer: a bibliometric analysis from 2004 to 2023. J Nanobiotechnology. 2023;21(1):248.10.1186/s12951-023-02033-8 ↗
10. Jensen SA, Day ES, Ko CH, Hurley LA, Luciano JP, Kouri FM, Merkel TJ, Luthi AJ, Patel PC, Cutler JI, Daniel WL, Scott AW, Rotz MW, Meade TJ, Giljohann DA, Mirkin CA, Stegh AH. Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma. Sci Transl Med. 2013;30(209):209re152.
11. Hadjipanayis CG, Machaidze R, Kaluzova M, Wang L, Schuette AJ, Chen H, Wu X, Mao H. EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma. Cancer Res. 2010;70(15):6303–12.10.1158/0008-5472.CAN-10-1022 ↗
12. Kouri FM, Hurley LA, Daniel WL, Day ES, Hua Y, Hao L, Peng CY, Merkel TJ, Queisser MA, Ritner C, Zhang H, James CD, Sznajder JI, Chin L, Giljohann DA, Kessler JA, Peter ME, Mirkin CA, Stegh AH. miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma. Genes Dev. 2015;29(7):732–45.10.1101/gad.257394.114 ↗
13. Perini G, Palmieri V, Ciasca G, D’Ascenzo M, Gervasoni J, Primiano A, Rinaldi M, Fioretti D, Prampolini C, Tiberio F, Lattanzi W, Parolini O, De Spirito M, Papi M. Graphene quantum dots’ surface chemistry modulates the sensitivity of glioblastoma cells to chemotherapeutics. Int J Mol Sci. 2020;21(17):6301.10.3390/ijms21176301 ↗
14. Yasaswi PS, Shetty K, Yadav KS. Temozolomide nano enabled medicine: promises made by the nanocarriers in glioblastoma therapy. J Control Release. 2021;10(336):549–71.10.1016/j.jconrel.2021.07.003 ↗
15. Helmi O, Elshishiny F, Mamdouh W. Targeted doxorubicin delivery and release within breast cancer environment using PEGylated chitosan nanoparticles labeled with monoclonal antibodies. Int J Biol Macromol. 2021;1(184):325–38.10.1016/j.ijbiomac.2021.06.014 ↗
16. Foo CY, Fu RZ. Unravelling the potential of graphene in glioblastoma therapy. Mater Sci Eng C Mater Biol Appl. 2021;128: 112330.10.1016/j.msec.2021.112330 ↗
17. Marino A, Camponovo A, Degl’Innocenti A, Bartolucci M, Tapeinos C, Martinelli C, De Pasquale D, Santoro F, Mollo V, Arai S, Suzuki M, Harada Y, Petretto A, Ciofani G. Multifunctional temozolomide-loaded lipid superparamagnetic nanovectors: dual targeting and disintegration of glioblastoma spheroids by synergic chemotherapy and hyperthermia treatment. Nanoscale. 2019;11(44):21227–48.10.1039/C9NR07976A ↗
18. Qi L, Pan T, Ou L, Ye Z, Yu C, Bao B, Wu Z, Cao D, Dai L. Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage. Commun Biol. 2021;4(1):214.10.1038/s42003-021-01713-1 ↗
19. Nejad ZK, Khandar AA, Khatamian M, Ghorbani M. Investigating of the anticancer activity of salen/salophen metal complexes based on graphene quantum dots: Induction of apoptosis as part of biological activity. Int J Pharm. 2023;25(642): 123092.10.1016/j.ijpharm.2023.123092 ↗