Bioactive P(VDF‐TrFE) Bandage Contact Lenses Enhance Corneal Wound Healing Through Microelectric Field Stimulation

Abstract Serving as the cornea's outermost barrier, the corneal epithelium is susceptible to persistent damage, which can lead to irreversible vision loss and severe neuropathic pain. Electrical stimulation bandage contact lenses (BCLs) can provide wound protection while accelerating the healing process. However, their opacity and complex design hinder their clinical adoption. This study proposes a bioactive BCL using poly(vinylidene fluoride‐ co ‐trifluoroethylene) (P(VDF‐TrFE)) through a simple fabrication process, which exhibits outstanding transparency and the ability to generate a uniform microelectric field over the injury site, while also offering superior smoothness, mechanical, and electrical properties. In vivo and in vitro experiments confirmed the excellent biocompatibility and effectiveness of P(VDF‐TrFE) BCLs in corneal epithelial wound healing, with RNA‐sequencing revealing the underlying mechanisms associated with corneal injury healing, such as cytoskeletal reorganization and inflammation regulation. Furthermore, the reorganization of the cytoskeleton and pseudopodia, which enhances the cellular ability to sense the injury environment and to promote migration and proliferation, is validated in co‐ cultured human corneal epithelial cells. Additionally, P(VDF‐TrFE) BCLs inhibit excessive inflammation during the injury process, promoting a favorable healing environment. These findings position P(VDF‐TrFE) as a promising treatment option for corneal injuries, highlighting the broader potential of ferroelectric polymers in ophthalmic tissue engineering.