DataVXAdvanced Functional MaterialsPaper
journal article·2022-10

Immunostimulant In Situ Hydrogel Improves Synergetic Radioimmunotherapy of Malignant Glioblastoma Relapse Post‐Resection (Adv. Funct. Mater. 43/2022)

Shuo Sun, Wei Gu, Haisi Wu, Qianqian Zhao, Shiyu Qian, Hong Xiao, Kun Yang, Jian Liu, Yu Jin, Chupeng Hu, Ye Gao, Huae Xu, Hongyi Liu, Jing Ji, Yun Chen

Advanced Functional Materials· Volume 32· Issue 43
Publisher page
Source abstract

Abstract

Flexible Optoelectronics In article number 2205038, Huae Xu, Hongyi Liu, Jing Ji, Yun Chen, and co-workers present an injectable, reactive oxygen species-responsive therapeutic hydrogel (ADU-AAV-PD1@Gel), capable of sustained local release of soluble PD-1 (sPD-1) and STING agonist ADU-S100. The ADU-AAV-PD1@Gel combined with radiotherapy generates a robust antitumor immune response and induces long-term immune memory to prevent glioblastoma recurrence.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersElectronic materials

OpenAlex topics: Nanoplatforms for cancer theranostics · Immune cells in cancer · Cancer Research and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurosurgery The Affiliated Brain Hospital of Nanjing Medical University Nanjing 210029 P. R. China

Department of Immunology Gusu School Nanjing Medical University Nanjing 210029 P. R. China

Department of Neurosurgery The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 P. R. China

Department of Pharmaceutics School of Pharmacy Nanjing Medical University Nanjing 210029 P. R. China

State Key Laboratory of Reproductive Medicine Department of Prenatal Diagnosis Women's Hospital of Nanjing Medical University Nanjing Maternity and Child Health Hospital Nanjing Medical University Nanjing 211166 P. R. China

Department of Immunology Key Laboratory of Human Functional Genomics of Jiangsu Province Gusu School Nanjing Medical University Nanjing 211166 P. R. China

Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University Nanjing 210029 P. R. China

Department of Central Laboratory The Affiliated Huai'an No.1 People's Hospital Nanjing Medical University Huai'an 223300 P. R. China

Department of Emergency The First Affiliation Hospital of Xi'an Jiaotong University Xian 710061 P. R. China

References

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