DataVXAdvanced Functional MaterialsPaper
journal article·2021-06

Biocompatible Light Guide‐Assisted Wearable Devices for Enhanced UV Light Delivery in Deep Skin

Hao Zhang, Hangbo Zhao, Xingyue Zhao, Chenkai Xu, Daniel Franklin, Abraham Vázquez‐Guardado, Wubin Bai, Jeffrey Zhao, Kan Li, Giuditta Monti, Wei Lu, Aya Kobeissi, Limei Tian, Xin Ning, Xinge Yu, Sunita Mehta, Debashis Chanda, Yonggang Huang, Shuai Xu, Bethany E. Perez White, John A. Rogers

Advanced Functional Materials· Volume 31· Issue 23
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Source abstract

Abstract

Abstract Phototherapy represents an attractive route for treating a range of challenging dermatological diseases. Existing skin phototherapy modalities rely on direct UV illumination, although with limited efficacy in addressing disorders of deeper tissue and with requirements for specialized illumination equipment and masks to shield unaffected regions of the skin. This work introduces a skin‐integrated optoelectronic device that incorporates an array of UVA (360 nm) light emitting diodes in layouts that match those of typical lesional plaques and in designs that couple to biocompatible, penetrating polymer microneedle light waveguides to provide optical access to deep skin. Monte Carlo simulations and experimental results in phantom skin suggest that these waveguides significantly enhance light delivery to deep skin, with a >4‐fold increase for depths of >500 µm. In ex vivo human skin, the devices show reduced measures of phototoxicity compared to direct illumination and enhanced modulation of gene expression relevant to sclerosing skin diseases. These systems are also compatible with design principles in soft, skin‐compatible electronics and battery‐powered wireless operation. Collectively, the favorable mechanical and light delivery properties of these devices expand possibilities in targeting of deep skin lesions beyond those attainable with clinical‐standard UV light therapy approaches.
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Research context

Energy storagePolymersBiomaterialsElectronic materials

OpenAlex topics: Skin Protection and Aging · Advancements in Transdermal Drug Delivery · Advanced Fluorescence Microscopy Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology Tsinghua University Beijing 100084 China

Department of Materials Science and Engineering Northwestern University Evanston IL 60208 USA

Center for Bio‐Integrated Electronics Northwestern University Evanston IL 60208 USA

Department of Aerospace and Mechanical Engineering University of Southern California Los Angeles CA 90089 USA

Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory University of Illinois at Urbana‐Champaign Urbana IL 61801 USA

State Key Laboratory of New Ceramics and Fine Processing and School of Materials Science and Engineering Tsinghua University Beijing 100084 China

Department of Science and Technology Innovation Beijing Academy of Artificial Intelligence Beijing 100084 China

Department of Biomedical Engineering Northwestern University Evanston IL 60208 USA

NanoScience Technology Center CREOL, The College of Optics and Photonics University of Central Florida Orlando FL 32826 USA

Department of Applied Physical Sciences University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Department of Dermatology Feinberg School of Medicine Northwestern University Chicago IL 60611 USA

Department of Civil and Environmental Engineering and Department of Mechanical Engineering Northwestern University Evanston IL 60208 USA

Beckman Institute for Advanced Science and Technology University of Illinois at Urbana‐Champaign Urbana IL 61801 USA

Department of Biomedical Engineering and Center for Remote Health Technologies and Systems Texas A&M University College Station TX 77843 USA

Department of Biomedical Engineering City University of Hong Kong Hong Kong SAR 999077 China

Department of Physics University of Central Florida Orlando FL 32826 USA

Departments of Materials Science and Engineering Biomedical Engineering, Neurological Surgery, Chemistry, Mechanical Engineering Electrical Engineering and Computer Science Simpson Querrey Institute and Feinberg Medical School Center for Bio‐Integrated Electronics Northwestern University Evanston IL 60208 USA

Funding

National Natural Science Foundation of China · National Psoriasis Foundation · National Science Foundation

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