journal article·2023-08Open access

Engineering Molybdenum‐Assisted Tellurium Nanosonosensitizers for Enhanced Sonodynamic Tumor Nanotherapy

Lile Dong, Wenjuan Li, Yu Luo, Chaoran Liu, Kai Li, Yu Chen, Guobin Hong

Advanced Functional Materials· Volume 33· Issue 31

Abstract

Abstract Materdicine‐augmented sonodynamic therapy has emerged as an efficient noninvasive strategy for cancer treatment by generating reactive oxygen species associated with the cavitation effect and sonosensitizers. However, semiconductor‐based inorganic nanosonosensitizers have undesirable nondegradability, which can cause unsatisfactory therapeutic efficacy and potential toxicity. With the aim of overcoming this obstacle, in this study, Mo‐assisted Te (MT) nanosonosensitizers with high oxidative degradation abilities are engineered for photoacoustic imaging (PA)‐guided sonodynamic tumor nanotherapy. Intriguingly, the engineered MT nanosonosensitizers can generate abundant singlet oxygen under ultrasound irradiation to eradicate tumor cells, thereby demonstrating its ability to achieve high tumor growth inhibition rates. In particular, MT nanosonosensitizers exhibit oxidative degradation properties that guarantee desirable biocompatibility and potentiate clinical translation. Therefore, this study validates a paradigm for theory‐oriented design of sonodynamic tumor nanotherapy.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Luminescence Properties of Advanced Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Radiology The Fifth Affiliated Hospital Sun Yat‐Sen University Zhuhai Guangdong 519000 P. R. China

Guangdong Provincial Key Laboratory of Biomedical Imaging The Fifth Affiliated Hospital, Sun Yat‐Sen University Zhuhai Guangdong 519000 P. R. China

Shanghai Engineering Research Center of Pharmaceutical Intelligent Equipment Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non‐Coding RNA Institute for Frontier Medical Technology School of Chemistry and Chemical Engineering Shanghai University of Engineering Science Shanghai 201620 P. R. China

State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China

Materdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. China

Funding

China Postdoctoral Science Foundation · National Natural Science Foundation of China

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