Native-like Flow Properties of an Artificial Spider Silk Dope
Source abstract
Abstract
Recombinant spider silk has emerged as a biomaterial that can circumvent problems associated with synthetic and naturally derived polymers, while still fulfilling the potential of the native material. The artificial spider silk protein NT2RepCT can be produced and spun into fibers without the use of harsh chemicals and here we evaluate key properties of NT2RepCT dope at native-like concentrations. We show that NT2RepCT recapitulates not only the overall secondary structure content of a native silk dope but also emulates its viscoelastic rheological properties. We propose that these properties are key to biomimetic spinning and that optimization of rheological properties could facilitate successful spinning of artificial dopes into fibers.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Silk-based biomaterials and applications · Biochemical and Structural Characterization · Invertebrate Immune Response Mechanisms
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Neo, Blickagången 16, Huddinge 141 52, Sweden
Department of Materials Science and Engineering, The University of Sheffield, Sir Robert Hadfield Building, Mappin Street, Sheffield S1 3JD, United Kingdom
Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala 750 07, Sweden
Funding
Svenska Forskningsr?det Formas · Vetenskapsr?det · Kommunfullm?ktige, Stockholms Stad · H2020 European Research Council · Karolinska Institutet, SFO Regen · Centrum f?r innovativ medicin, Karolinska Institutet
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