ACS BIOMATERIALS SCIENCE & ENGINEERING

Mei-Ching Yu, Tzu-Wei Chung, Wei-Cheng Lin, Chien-Hung Liao

Trimethylamine N-oxide (TMAO) has recently emerged as a clinically relevant biomarker for the early diagnosis and risk stratification of chronic diabetic nephropathy and cardiovascular disease. Here, we report an electric-field-driven pixel array urine biosensor for the assessment of diabetic nephropathy and for elucidating the relationship among urine TMAO, glucose, and urine …

Bo-Cheng Wu, Da-Ming Wang, Yung Chang

Biofouling of titanium implants, initiated by nonspecific protein adsorption and followed by bacterial and cellular adhesion, remains a critical challenge that compromises long-term implant performance. Herein, we report a covalent interfacial engineering strategy to construct a robust zwitterionic sulfobetaine interface on titanium via a stepwise grafting approach. This method…

Yaya Du, Mengya Zhao, Zhuo Zuo, Yulong Sun

Bioelectrical signals, particularly endogenous direct-current electric fields (EFs), constitute a pivotal yet often underappreciated class of physical cues within the cellular microenvironment. Macrophages, as central effectors of the innate immune system, exhibit remarkable plasticity in response to physicochemical stimuli. Accumulating evidence indicates that both endogenous …

Isabela Santos, Seokgyu Han, Omar Gabriel Hernández Zapata, Brittany Alejandra Garibay Corral et al.

Osteosarcoma (OS) is the most frequent primary bone malignancy, with stagnant therapeutic progress. The current chemotherapy treatment shows limited efficacy in disseminating metastasis, and its recurrent use is associated with high systemic toxicity. Moreover, the absence of effective therapeutic strategies along with low complexity models for drug screen analysis hinders ther…

Nadia A. Vázquez-Torres, Elizabeth González-García, Itzel M. Garnica-Palafox, Gabriela Piñón-Zárate et al.

We demonstrate the feasibility of semi-interpenetrating polymeric networks (SIPNs) based on poly(dimethylsiloxane) (PDMS), chitosan (CS), poly(vinyl alcohol) (PVA), and genipin (GEN). Three different weight ratios of PDMS and CS/PVA/GEN -SIPNs 7:3, 5:5, and 3:7, respectively, were prepared via solvent-casting for skin wound dressings. These SIPNs exhibited thicknesses of 300-55…

Xiao Mi, Ziqi Wang, Zhihui Xiong, Yuqiong Wu et al.

Additive manufacturing of biomedical titanium (Ti) alloys has attracted significant interest because of their potential use in patient-specific biomedical devices. Iron (Fe), an effective β-stabilizer, is capable of replacing toxic alloying elements, such as aluminum (Al) and vanadium (V), in biocompatible biomedical Ti-alloys. In this study, a Ti-2Fe alloy was produced using l…

Yikun Sun, Mingjun Li, GuiPeng Hao, Zhen Yang et al.

Postoperative re-tear remains a prevalent challenge in rotator cuff repair. To address this, we developed a bioactive glass composite rotator cuff patch (BCP) with heterogeneous structural design to promote tendon−bone interface regeneration. The BCP features an outer barrier of hydrophobic poly (lactic acid) (PLA) electrospun membrane, which prevents infiltration of inflammato…

Rewati Raman Ujjwal, Ashish Dilip Sutar, Rahul Shukla, Gymama Slaughter

Antimicrobial resistance (AMR) is a major global health challenge driven by mechanisms such as biofilm formation, efflux pumps, and genetic mutations. Nanoparticulate and fibrous materials have emerged as promising strategies to overcome these limitations through multimodal antimicrobial action and controlled drug delivery. This review highlights recent advances in electrospun …

Qingyu Xu, Jizhe Hai, Jie Chen

Irregular porous scaffolds based on Voronoi tessellation have attracted growing interest in bone tissue engineering because their geometric heterogeneity more closely resembles native bone than conventional periodic lattices. However, current Voronoi scaffold designs remain largely limited to homogeneous or axially graded architectures, whereas radially graded irregular scaffol…

Bhaben Sharmah, Hiranmoy Barman, Nazim Afzal, Rikraj Loying et al.

Abstract not available. Bibliographic information is searchable.

Shiqin Dai, Ahmed Nabil, Yoshitaka Matsumoto, Muyasha Abulimiti et al.

Glioblastoma (GBM) remains one of the most aggressive brain tumors, with limited treatment efficacy due to tumor invasiveness, drug resistance, and the blood-brain barrier. Tumor treating fields (TTFs) provide a non-invasive strategy by disrupting cancer cell mitosis using alternating electric fields, but current systems rely on external electrodes and suffer from low field pen…

Liam Gillman, Djordji Suleski, Mark E. Graham, Samantha L. Ginn et al.

Abstract Designing therapeutic payloads to deliver drug molecules to the desired target site is challenging and requires effective, stable, and safe delivery systems in cancer therapy. Lipid-based nanocarriers have gained substantial interest in preclinical and clinical studies in anticancer drugs, leveraging their potential for drug delivery over the last few decades. While li…

Junjie Liang, Hongxin Chen, Mei Li, Zengquan Tang et al.

Insufficient removal of reactive oxygen species (ROS) and macrophage M1/M2 polarization in the joint cavity are key factors in the progression of OA. Recent findings have shown that the combination of polydopamine (PDA) and platelet-rich plasma (PRP) is expected to be a promising strategy to treat OA. In light of the short retention period of nanodots in joints, we employed Pol…

Authors not provided

Abstract not available. Bibliographic information is searchable.

Authors not provided

Abstract not available. Bibliographic information is searchable.

Ashok Vishwakarma, Archana Raichur, Niraj Sinha

The management of large-scale bone defects, particularly in oncological contexts, necessitates scaffolds that provide both structural resilience and protection against recalcitrant infections. In this study, we developed multifunctional 3D-printed magnetic bioactive glass (MBG) scaffolds with a composition of 45SiO 2 –20Na 2 O–23CaO–6P 2 O 5 –2.5B 2 O 3 –1ZnO–2MgO–0.5CaF 2, rei…

Boyuan An, Qin Zeng, Lichao Zhang, Zhanrong Li et al.

Tissue trauma or chemical injury can compromise tissue integrity and trigger an inflammatory response, which can severely hinder the tissue repair process, particularly in patients with diabetes. Existing wound repair methods struggle to strike a balance between efficacy and cost. We develop a novel natural-based nano-cellulose membrane (LOBCC) by combining lignin-based carbon …

Chengru Li, Kechao Wang, Shu Xia, Pengfei Hu et al.

Diabetic wounds (DWs), characterized by pathological features of healing stagnation and limited regeneration, pose significant clinical challenges in chronic wound management and contribute to substantial consumption of healthcare resources. Although current clinical interventions heavily rely on debridement, offloading, and traditional wound dressings, their therapeutic effica…

Kate Firipis, Anne M Kong, Stephanie Doyle, Damien G Grinsell et al.

High Resolution Image Download MS PowerPoint Slide This study develops 3D-printed hollow structures for tissue engineering purposes, with particular focus on the development of branched hierarchical medium-sized blood vessels in the 1–2 mm diameter range. Hierarchical medium-sized branched blood vessels that link an incorporated capillary network within engineered tissues to th…

Feiyu Chen, Ziying Xu, Yue Liu, Daniel Yan et al.

Extracellular matrix (ECM) organization is important for integrating interactions between cells into functional tissues. A well-known example is the cellular alignment in skeletal and cardiac muscles, tendons, bones, and corneas, all of which are guided by aligned ECM fibrils. However, no current ECM alignment technique is adequate for disease modeling and regenerative medicine…