Plant-Based Scaffolds in Tissue Engineering
Source abstract
Abstract
A wide range of platforms has been developed for 3D culture of cells in vitro to aggregate and align cells to resemble in vivo conditions in order to enhance communication between cells and promote differentiation. The cellulose skeleton of plant tissue can serve as an attainable scaffold for mammalian cells after decellularization, which is advantageous when compared to synthetic polymers or animal-derived scaffolds. Adjustable variables to modify the physical and biochemical properties of the resulting scaffolds include the protocol for the sodium dodecyl sulfate (SDS)-based decellularization procedure, surface coatings for cell attachment, plant type for decellularization, differentiation media, and integrity and shape of the substrate. These tunable cellulose platforms can host a wide range of mammalian cell types from muscle to bone cells, as well as malignancies. Here, fundamentals and applications of decellularized plant-based scaffolds are discussed. These biocompatible, naturally perfused, tunable, and easily prepared decellularized scaffolds may allow eco-friendly manufacturing frameworks for application in tissue engineering and organs-on-a-chip.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Tissue Engineering and Regenerative Medicine · 3D Printing in Biomedical Research · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Medicine, Koç University, Sariyer, Istanbul, Turkey 34450
Boğaziçi Institute of Biomedical Engineering, Boğaziçi University, Çengelköy, Istanbul, Turkey 34684
Interdisiplinary Research Unit for Advanced Materials (INTRAM), Ankara University, Ankara, Turkey 06560
Department of Chemistry, Ankara University, Ankara, Turkey 06560
Department of Chemical Engineering, Imperial College London, London SW7 2AZ, United Kingdom
Department of Mechanical Engineering, Koç University, Sariyer, Istanbul, Turkey 34450
Koc University Research Center for Translational Medicine, Koç University, Sariyer, Istanbul, Turkey 34450
Koç University Arçelik Research Center for Creative Industries (KUAR), Koç University, Sariyer, Istanbul, Turkey 34450
Center for Life Sciences and Technologies, Bogazici University, Bebek, Istanbul, Turkey 34470
Funding
Royal Academy of Engineering · H2020 Marie Sklodowska-Curie Actions · Alexander von Humboldt-Stiftung · T?rkiye Bilimsel ve Teknolojik Arastirma Kurumu
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