3-D Human Renal Tubular Organoids Generated from Urine-Derived Stem Cells for Nephrotoxicity Screening
Source abstract
Abstract
The development of human cell-based systems to replace the use of rodents or the two-dimensional culture of cells for studying nephrotoxicity is urgently needed. Human urine-derived stem cells were differentiated into renal tubular epithelial cells in three-dimensional (3-D) culture after being induced by a kidney extracellular matrix. Levels of CYP2E1 and KIM-1 in 3-D organoids were significantly increased in response to acetone and cisplatin. This 3-D culture system provides an alternative tool for nephrotoxicity screening and research.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Renal and related cancers · Pluripotent Stem Cells Research · Organ Donation and Transplantation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, United States
Reproductive Medicine, Henan Provincial People’s Hospital, Zhengzhou, Henan 450003, China
Department of Urology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China
Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, United States
Funding
U.S. Department of Health and Human Services
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