journal article·2019-07-08

Multifunctional Tannic Acid (TA) and Lysozyme (Lys) Films Built Layer by Layer for Potential Application on Implant Coating

Shuoshuo Yang, Yong Wang, Xiaoxiao Wu, Sunren Sheng, Tian Wang, Xingjie Zan

Publisher page

Abstract

A multifunctional (TA/Lys)n film, featuring good antioxidant property, fast cell attachment at the initial stage, enhanced osteogenesis, and broad-spectrum antibacterial property, was constructed by the layer-by-layer (LBL) method. The building process was monitored by quartz crystal microbalance with dissipation (QCM-D); the physical properties, such as topography, stiffness in dry and liquid state, and conformation of Lys in the film, were thoroughly characterized. These physical properties were modulated by varying the salt concentration at which the film was constructed. The film not only allows for favorable cell attachment and proliferation of preosteoblasts Mc3t3-E1 but also provides antibacterial property against Gram-positive bacteria, S. aureus and M. lysodeikticus, and Gram-negative bacteria, E. coli. It also displays good antioxidant property, which plays a critical role on fast cell attachment at the initial stage.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Polymer Surface Interaction Studies · Dental materials and restorations

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, PR China

Wenzhou Institute of Biomaterials and Engineering, CNITECH, Chinese Academy of Sciences, Wenzhou, Zhejiang Province 325001, PR China

Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, Zhejiang Province 325001, PR China

Institute for Energy Research, Jiangsu Uniersity, Zhenjiang 212013, PR China

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, PR China

Funding

Wenzhou Municipal Science and Technology Bureau · National Natural Science Foundation of China · Wenzhou Government

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