DataVXACS Biomaterials Science & EngineeringPaper
journal article·2019-09-09

Polypyrrole Nanocones and Dynamic Piezoelectric Stimulation-Induced Stem Cell Osteogenic Differentiation

Zhengnan Zhou, Peng Yu, Lei Zhou, Lingjie Tu, Lei Fan, Fengmiao Zhang, Cong Dai, Yi Liu, Chengyun Ning, Jianqiang Du, Guoxin Tan

ACS Biomaterials Science & Engineering· Volume 5· Issue 9
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Source abstract

Abstract

Imitating the physiological microenvironment of living cell and tissues opens new avenues of research into the application of electricity to medical therapies. In this study, dynamic piezoelectric stimulation is generated in a dynamic culture because of the piezoelectric effect of the poly(vinylidene fluoride)-polypyrrole (PVDF-PPy) electroactive composite. Combined with PPy nanocones, dynamic piezoelectric signals are effectively and continuously provided to cells. In the presence of dynamic piezoelectric stimulation and PPy nanocones, PPy-PVDF NS samples show promoted bone mesenchymal stem cell (BMSCs) adhesion, spreadin, and osteogenic differentiation. On the basis of the results of this study, PPy nanocones and dynamic piezoelectric stimulation can be administered to modulate cell behavior, paving the way for the exploration of cellular responses to dynamic electrical stimulation.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsComposites

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Neuroscience and Neural Engineering · Conducting polymers and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China

School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China

Guangdong Key Laboratory of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou 510006, China

Orthopedics Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China

Department of Nuclear Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China

Funding

China Postdoctoral Science Foundation · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Technological Projects of Guangzhou

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