Microfluidic Systems For Manufacturing of Microparticle-Based Drug-Delivery Systems: Design, Construction, and Operation
Source abstract
Abstract
Particles synthesized from biodegradable polymers hold great potential as controlled drug delivery systems. Continuous flow platforms based on microfluidics offer attractive advantages over conventional batch-emulsification techniques for the scalable fabrication of drug-loaded particles with controlled physicochemical properties. However, widespread utilization of microfluidic technologies for the manufacturing of drug-loaded particles has been hindered largely by the lack of practical guidelines toward cost-effective development and reliable operation of microfluidic systems. Here, we present a framework for rational design and construction of microfluidic systems using commercially available components for high-throughput production of uniform biodegradable particles encapsulating drugs. We also demonstrate successful implementation of this framework to devise a robust microfluidic system that is capable of producing drug-carrying particles with desired characteristics. The guidelines provided in this study will likely help broaden the applicability of microfluidic technologies for the synthesis of high-quality, drug-loaded biodegradable particles.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Innovative Microfluidic and Catalytic Techniques Innovation · Microfluidic and Capillary Electrophoresis Applications · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical Engineering, University of Pittsburgh, 3700 O’Hara Street, 940 Benedum Hall, Pittsburgh, Pennsylvania 15261, United States
Department of Dermatology, University of Pittsburgh School of Medicine, 200 Lothrop Street, W1150 Biomedical Science Tower, Pittsburgh, Pennsylvania 15213, United States
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States
Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States
The McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States
Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States
Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States
Funding
National Institute of Arthritis and Musculoskeletal and Skin Diseases · Commonwealth of Pennsylvania?s Department of Community and Economic Development
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