Glutathione-Responsive Polymeric Micelles Formed by a Biodegradable Amphiphilic Triblock Copolymer for Anticancer Drug Delivery and Controlled Release
Source abstract
Abstract
-poly(ethylene glycol) triblock copolymer that self-assembles into micellar nanoparticles and simutaneously carry hydrophobic anticancer drugs such as doxirubicin. These drug-loading micelles show glutathione-triggered decomposition that leads to controlled drug release and cytotoxicity to cancer cells. This polymeric drug-carrier system integrates features of facile synthesis, stimuli-responsive drug release, good biocompatibility, and relatively low toxicity of the dissociated segments, thus representing a promising anticancer drug carrier for potential clinical applications.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Advanced Polymer Synthesis and Characterization
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore
Funding
Ministry of Education - Singapore · Nanyang Technological University
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