DataVXACS Biomaterials Science & EngineeringPaper
journal article·2023-06-12

Silk Fibroin-Based Hydrogel Microneedles Deliver α-MSH to Promote Melanosome Delivery for Vitiligo Treatment

Shubin Chong, Chengxiu Wei, Longbao Feng, Rui Guo

ACS Biomaterials Science & Engineering· Volume 9· Issue 6
Publisher page
Source abstract

Abstract

Microneedles have shown great advantages in subcutaneous drug delivery and skin disease treatment. Vitiligo is a difficult-to-cure skin disease characterized by the depigmentation of the epidermis. Melanosomes produced in melanocytes are transported through dendrites to adjacent keratinocytes, where they accumulate, resulting in skin pigmentation. However, melanocytes in vitiligo patients are functionally disrupted. Silk fibroin (SF) methacrylate hydrogel microneedle can deliver α-MSH to the epidermis directly, where α-MSH helps the protection of melanocytes, extension of melanocytic dendrites, and transfer of melanosomes. In addition, the expression of melanogenesis-related melanocyte-inducing transcription factor and tyrosinase-related protein 1 (TRP1) was up-regulated, and the number of hair follicle stem cells increased with good proliferative activity. This slow release α-MSH SF-based hydrogel microneedles provides a new idea for the treatment of vitiligo.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: melanin and skin pigmentation · Silk-based biomaterials and applications · Skin Protection and Aging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Dermatology, Sixth Affiliated Hospital of South China University of Technology, Foshan 528200, China

Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China

Funding

Guangdong Science and Technology Department · Guangdong Province Introduction of Innovative R&D Team · Ministry of Science and Technology of the People's Republic of China · Department of Natural Resources · Guangzhou Municipal Science and Technology Bureau · International Science and Technology Cooperation Project of Huangpu District/Guangzhou Development District · Key Areas and Development Program of Guangzhou

References (35)

Show source-provided references
1. 10.1111/j.1755-148x.2012.00997.x10.1111/j.1755-148x.2012.00997.x ↗
2. 10.1016/j.autrev.2021.10293210.1016/j.autrev.2021.102932 ↗
3. 10.1002/med.2175410.1002/med.21754 ↗
4. 10.1111/1346-8138.1574310.1111/1346-8138.15743 ↗
5. 10.1046/j.1529-8019.2003.01621.x10.1046/j.1529-8019.2003.01621.x ↗
6. 10.1016/j.dsi.2014.05.00210.1016/j.dsi.2014.05.002 ↗
7. 10.1111/j.1749-6632.1999.tb08679.x10.1111/j.1749-6632.1999.tb08679.x ↗
8. 10.22034/ijd.2020.12083610.22034/ijd.2020.120836 ↗
9. 10.1016/j.cellsig.2017.09.00410.1016/j.cellsig.2017.09.004 ↗
10. 10.1111/j.1600-0749.1997.tb00688.x10.1111/j.1600-0749.1997.tb00688.x ↗
11. 10.1034/j.1600-0749.2002.02056.x10.1034/j.1600-0749.2002.02056.x ↗
12. 10.1034/j.1600-0749.2001.140402.x10.1034/j.1600-0749.2001.140402.x ↗
13. 10.1111/j.1749-6632.2003.tb03172.x10.1111/j.1749-6632.2003.tb03172.x ↗
14. 10.3390/ph1401004510.3390/ph14010045 ↗
15. 10.1016/j.jdermsci.2015.09.00310.1016/j.jdermsci.2015.09.003 ↗
16. 10.1111/exd.1210310.1111/exd.12103 ↗
17. 10.3390/polym1416330710.3390/polym14163307 ↗
18. 10.1016/j.biopha.2018.10.07810.1016/j.biopha.2018.10.078 ↗
19. 10.1126/sciadv.abe288810.1126/sciadv.abe2888 ↗
20. 10.1016/j.jddst.2021.10236410.1016/j.jddst.2021.102364 ↗
21. 10.1016/j.carbpol.2020.11665010.1016/j.carbpol.2020.116650 ↗
22. 10.1002/mabi.20217000310.1002/mabi.202170003 ↗
23. 10.1016/j.addr.2012.09.04310.1016/j.addr.2012.09.043 ↗
24. 10.1016/j.carbpol.2020.11668910.1016/j.carbpol.2020.116689 ↗
25. 10.1016/j.cej.2021.13042910.1016/j.cej.2021.130429 ↗
26. 10.1021/acsami.9b1566810.1021/acsami.9b15668 ↗
27. 10.1111/pcmr.1298510.1111/pcmr.12985 ↗
28. 10.1021/acsbiomaterials.1c0091310.1021/acsbiomaterials.1c00913 ↗
29. 10.1016/j.autrev.2020.10266410.1016/j.autrev.2020.102664 ↗
30. 10.1021/acsnano.1c0532110.1021/acsnano.1c05321 ↗
31. 10.1007/s12247-020-09460-210.1007/s12247-020-09460-2 ↗
32. 10.1089/scd.2021.027610.1089/scd.2021.0276 ↗
33. 10.1016/j.addr.2017.10.01010.1016/j.addr.2017.10.010 ↗
34. 10.1038/jid.2011.46310.1038/jid.2011.463 ↗
35. 10.3389/fimmu.2021.79012510.3389/fimmu.2021.790125 ↗