Ultrasonic Formation of Fe3O4-Reduced Graphene Oxide–Salicylic Acid Nanoparticles with Switchable Antioxidant Function
Source abstract
Abstract
We demonstrate a single-step ultrasonic in situ complexation of salicylic acid during the growth of Fe3O4-reduced graphene oxide nanoparticles (∼10 nm) to improve the antioxidant and antiproliferative effects of pristine drug molecules. These nanoparticles have a precisely defined electronic molecular structure with salicylic acid ligands specifically complexed to Fe(III)/Fe(II) sites, four orders of magnitude larger electric surface potential, and enzymatic activity modulated by ascorbic acid molecules. The diminishing efficiency of hydroxyl radicals by Fe3O4-rGO-SA nanoparticles is tenfold higher than that by pristine salicylic acid in the electro-Fenton process. The H+ production of these nanoparticles can be switched by the interaction with ascorbic acid ligands and cause the redox deactivation of iron or enhanced antioxidation, where rGO plays an important role in enhanced charge transfer catalysis. Fe3O4-rGO-SA nanoparticles are nontoxic to erythrocytes, i.e., human peripheral blood mononuclear cells, but surpassingly inhibit the growth of three cancer cell lines, HeLa, HepG2, and HT29, with respect to pristine salicylic acid molecules.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Nanoparticles: synthesis and applications · Vitamin C and Antioxidants Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratory of Integrated Micro- and Nanosystems, Belarusian State University of Informatics and Radioelectronics, P. Brovki str. 6, 220013 Minsk, Republic of Belarus
Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus, Academicheskaya str. 27, 220072 Minsk, Republic of Belarus
Department of Microbiology, Belarusian State University, Kurchatava str. 10, 220030 Minsk, Republic of Belarus
Laboratory of Applied Plasmonics, Belarusian State University of Informatics and Radioelectronics, P. Brovki str. 6, 220013 Minsk, Republic of Belarus
Scientific-Technical Center “Belmicrosystems”, Kazintsa str. 121 A, 220108 Minsk, Republic of Belarus
Funding
Belarusian Republican Foundation for Fundamental Research · Belarusian Fundamental Research of Ministry of Education for young scientists · Belarusian Fundamental Research Program · Polish National Agency for Academic Exchange EUROPARTNER
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