Multi-scale strengthened Fe-1Se alloy with antibacterial and antitumor properties for orthopedic applications
Source abstract
Abstract
Biodegradable Fe-Se alloys are promising for bone-cancer defect repair owing to their significant antitumor properties. However, the inadequate strength and plasticity of as-cast Fe-Se alloys necessitate further research to improve their mechanical properties. In this study, we prepared a high-strength Fe-1Se alloy using ultrahigh-pressure solution treatment. The microstructure of the ultrahigh-pressure solution-treated (UPST) Fe-1Se alloy consisted of body-centered cubic (BCC) α-Fe ferrite, martensite, and FeSe second phase. The solid solubility of Se in the α-Fe matrix of the UPST Fe-1Se alloy significantly increased to 0.53 at. %. Due to the combined strengthening effects of the martensite structure, FeSe nanoprecipitate clusters, and the supersaturated solid solution, the UPST Fe-1Se alloy exhibited a yield strength of 1072.1 ± 5.8 MPa, 4 times that of its solid-solution-treated (SST) counterpart under atmospheric pressure and around 7 times that of the extruded magnesium alloy WE43. Further, the UPST Fe-1Se alloy showed antibacterial capacity against Staphylococcus aureus, biocompatibility with pre-osteoblast MC3T3-E1 cells, and antitumor efficacy against osteosarcoma MG63 cells. In summary, the UPST Fe-1Se alloy has broad prospects in orthopedic applications based on its unique mechanical and biofunctional properties. STATEMENT OF SIGNIFICANCE: This work reports the multiple strengthening mechanisms, corrosion and degradation behaviors, biocompatibility, and biofunctionalities of an ultrahigh-pressure solution-treated Fe-1Se alloy. The microstructure of the alloy consisted of body-centered cubic α-Fe ferrite, martensite, and FeSe second phase. The solid solubility of Se in the α-Fe matrix of the alloy increased to 0.53 at. %. The alloy exhibited a compressive yield strength of ∼1072 MPa. Moreover, the alloy showed antibacterial capacity against S. aureus, biocompatibility in relation to pre-osteoblast MC3T3-E1 cells, and antitumor efficacy against osteosarcoma MG63 cells. In summary, the alloy has broad prospects in orthopedic applications due to its unique mechanical and biofunctional properties.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · High Entropy Alloys Studies · Titanium Alloys Microstructure and Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (74)
Show source-provided references
1. Novel bone tumor cell targeting nanosystem for chemo-photothermal therapy of malignant bone tumors
2. Self-assembly nanoparticles potentiate in-situ tumor vaccine of radiotherapy by regulating tumor immunogenicity and tumor-associated macrophages10.1016/j.cej.2024.154663 ↗
3. Prevention and treatment of radiotherapy-induced side effects10.1002/1878-0261.12750 ↗
4. The side effects of platinum-based chemotherapy drugs: a review for chemists10.1039/C8DT00838H ↗
5. New insights and perspectives into biodegradable metals in cardiovascular stents: a mini review
6. Technology, biodegradable Zn-3Cu and Zn-3Cu-0.2 Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications10.1016/j.jmst.2020.06.052 ↗
7. Moving research direction in the field of metallic bioresorbable stents-A mini-review
8. In vitro biodegradation behavior, mechanical properties, and cytotoxicity of biodegradable Zn-Mg alloy10.1002/jbm.b.33341 ↗
9. Additive manufacturing of biodegradable magnesium-based materials: design strategies, properties, and biomedical applications10.1016/j.jma.2022.12.001 ↗
10. Lithium-induced optimization mechanism for an ultrathin-strut biodegradable Zn-based vascular scaffold10.1002/adma.202301074 ↗
11. Mg-, Zn-, and Fe-based alloys with antibacterial properties as orthopedic implant materials
12. Additively manufactured biodegradable porous iron10.1016/j.actbio.2018.07.011 ↗
13. High strength, biodegradable and cytocompatible alpha tricalcium phosphate-iron composites for temporal reduction of bone fractures10.1016/j.actbio.2018.02.002 ↗
14. A biodegradable Zn-5Gd alloy with biomechanical compatibility, cytocompatibility, antibacterial ability, and in vitro and in vivo osteogenesis for orthopedic applications10.1016/j.actbio.2024.01.018 ↗
15. Biodegradable metals10.1016/j.mser.2014.01.001 ↗
16. Engineering, In vitro degradation, hemocompatibility, and cytocompatibility of nanostructured absorbable Fe-Mn-Ag alloys for biomedical application10.1021/acsbiomaterials.0c00263 ↗
17. Degradation behavior of austenite, ferrite, and martensite present in biodegradable Fe-based alloys in three protein-rich pseudo-physiological solutions
18. Additive manufacturing of bioactive and biodegradable porous iron-akermanite composites for bone regeneration10.1016/j.actbio.2022.06.009 ↗
19. FePt nanoparticles as an Fe reservoir for controlled Fe release and tumor inhibition10.1021/ja905938a ↗
20. interfaces, photothermal therapy nanomaterials boosting transformation of Fe (III) into Fe (II) in tumor cells for highly improving chemodynamic therapy10.1021/acsami.9b11291 ↗
21. The effect of Si addition and thermomechanical processing in an Fe-Mn alloy for biodegradable implants: mechanical performance and degradation behavior
22. Fabrication of a biodegradable Fe-Mn-Si alloy by field assisted sintering10.1016/j.apt.2020.10.012 ↗
23. A comparative study of powder metallurgical (PM) and wrought Fe-Mn-Si alloys10.1016/j.msea.2015.02.021 ↗
24. Mechanical and functional properties of Fe-Mn-Si biodegradable alloys fabricated by laser powder bed fusion: effect of heat treatment10.1016/j.msea.2024.146725 ↗
25. Downregulation of selenium-binding protein 1 is associated with poor prognosis in lung squamous cell carcinoma10.1186/s12957-016-0832-6 ↗
26. Metabolism of selenite in Human lung cancer cells: x-ray absorption and fluorescence studies10.1021/ja206203c ↗
27. Thermosensitive hydrogels for sustained-release of sorafenib and selenium nanoparticles for localized synergistic chemoradiotherapy10.1016/j.biomaterials.2019.05.031 ↗
28. Osteosarcoma cell apoptosis induced by selenium10.1016/S0736-0266(00)00079-6 ↗
29. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: a randomized controlled trial10.1001/jama.1996.03540240035027 ↗
30. The Se−Sn (selenium-tin) system
31. ZnSe nanostructures: synthesis, properties and applications10.1016/j.pmatsci.2016.07.005 ↗
32. Room temperature compressive properties and strengthening mechanism of Mg96.17Zn3.15Y0.50Zr0.18 alloy solidified under high pressure10.1016/j.jre.2019.05.015 ↗
33. Unique strengthening mechanisms of ultrahigh pressure Mg alloys
34. Improved mechanical and corrosion properties through high-pressure phase transition in a biodegradable Zn-1.5 Mn alloy10.1016/j.corsci.2024.112399 ↗
35. Ultrahigh strength and uniform corrosion in Zn-Li alloys through ultrahigh pressure supersaturated solid solution treatment for biodegradable orthopedic applications10.1007/s12598-024-02753-2 ↗
36. High-pressure quenching effect on martensitic transformation characteristics and mechanical properties of low-alloy medium-carbon steel10.1016/j.jmrt.2023.01.051 ↗
37. ASTM E8/E 8M-16Standard Test Methods For Tension Testing of Metallic Materials, ASTM International, West Conshohocken, PA, 2011.
38. ASTM G102-89Standard practice for calculation of corrosion rates and related information from electrochemical measurements, ASTM International, West Conshohocken, PA, 2015.
39. ASTM G31-72, Standard Practice For Laboratory Immersion Corrosion Testing of Metals, ASTM International, West Conshohocken, PA, 2004.
40. ASTM G31-12Standard Guide for Laboratory Immersion Corrosion Testing of Metals, ASTM International, West Conshohocken, PA, 2013.
41. DIN EN ISO 20645-2004, Textile Fabrics-Determination of Antibacterial Activity-Agar Diffusion Plate Test, International Organisation for Standardization, Geneva, Switzerland, 2004.
42. ISO 10993-5: 2009, Biological Evaluation of Medical Devices. Part 5: Tests for in Vitro Cytotoxicity, International Organisation For Standardization, Geneva, Switzerland, 2009.
43. The effect of high pressure on the martensitic reaction in iron-carbon alloys10.1016/0001-6160(62)90117-7 ↗
44. A biodegradable Zn-Se alloy with potent osteogenicity, antibacterial ability, and antitumor efficacy for bone-implant applications
45. Achieving exceptional work-hardening capability of additively-manufactured multiphase Fe-Mn alloys via multiple deformation mechanisms10.1016/j.ijplas.2023.103871 ↗
46. Additively manufactured hierarchical stainless steels with high strength and ductility10.1038/nmat5021 ↗
47. Multistage strain hardening through dislocation substructure and twinning in a high strength and ductile weight-reduced Fe-Mn-Al-C steel10.1016/j.actamat.2012.07.018 ↗
48. Stacking fault energy and deformation mechanisms in Fe-xMn-0.6C-yAl TWIP steel10.1016/j.msea.2016.08.106 ↗
49. Cluster mediated high strength and large ductility in a strip casting micro-alloyed steel[J]10.1016/j.actamat.2024.120102 ↗
50. Microstructural, corrosion and mechanical properties of a WE43 alloy: conventional extrusion versus SPD10.1016/j.jallcom.2023.173090 ↗
51. Novel processing of iron–manganese alloy-based biomaterials by inkjet 3-D printing10.1016/j.actbio.2013.04.016 ↗
52. Degradable metallic biomaterials: design and development of Fe–Mn alloys for stents10.1002/jbm.a.32224 ↗
53. The mechanical properties of cortical bone10.2106/00004623-197456050-00012 ↗
54. Characterization of chemical short-range order in VCoNi medium-entropy alloy processed by spark plasma sintering10.1016/j.scriptamat.2023.115463 ↗
55. Conditions of warm ausforming of low-alloy medium-carbon steel for making fully martensitic microstructure and its refining effect of martensite
56. Technology, effect of matrix carbon content and lath martensite microstructures on the tempered precipitates and impact toughness of a medium-carbon low-alloy steel10.1016/j.jmrt.2020.05.002 ↗
57. Influence of high-pressure quenching on the microstructure, martensite transformation, and mechanical properties of 0.2 mass% C steel10.2355/isijinternational.ISIJINT-2020-784 ↗
58. High pressure induced ultra-hard twinned lath martensite in binary Fe-15wt.% Cr alloy10.1016/j.scriptamat.2020.06.004 ↗
59. Formation of hierarchically structured martensites in pure iron with ultrahigh strength and stiffness10.1073/pnas.2408119121 ↗
60. A general mechanism of martensitic nucleation: part II. FCC→ BCC and other martensitic transformations
61. Ductile 2-GPa steels with hierarchical substructure10.1126/science.add7857 ↗
62. Diffraction analysis of α-Fe precipitates in a polycrystalline Cu-Fe alloy10.1016/j.matchar.2015.05.012 ↗
63. Design and evaluation a kind of functional biomaterial for bone tissue engineering: selenium/mesoporous bioactive glass nanospheres10.1016/j.jcis.2020.06.122 ↗
64. Staphylococcus aureus10.1016/B978-012677530-3/50258-0 ↗
65. materials, antibacterial biodegradable Mg-Ag alloys10.22203/eCM.v025a20 ↗
66. Influence of Cu2+ on sulfate-reducing bacteria associated with magnesium alloy10.2355/isijinternational.47.1647 ↗
67. Corrosion resistance and antibacterial properties of Ag-containing MAO coatings on AZ31 magnesium alloy formed by microarc oxidation10.1149/1.3301829 ↗
68. Characterisation of copper oxide nanoparticles for antimicrobial applications10.1016/j.ijantimicag.2008.12.004 ↗
69. Preliminary study of anti-infective function of a copper-bearing stainless steel10.1016/j.msec.2012.03.009 ↗
70. A biodegradable Fe-0.6 Se alloy with superior strength and effective antibacterial and antitumor capabilities for orthopedic applications10.1016/j.actbio.2024.10.012 ↗
71. The recent biological applications of selenium-based nanomaterials10.1016/j.nantod.2021.101205 ↗
72. Microstructure, mechanical properties, degradation behavior, and biocompatibility of porous Fe-Mn alloys fabricated by sponge impregnation and sintering techniques10.1016/j.actbio.2020.07.048 ↗
73. In vitro and in vivo mechanism of bone tumor inhibition by selenium-doped bone mineral nanoparticles10.1021/acsnano.6b03835 ↗
74. Redox-active selenium compounds-from toxicity and cell death to cancer treatment10.3390/nu7053536 ↗