Degradation and drug release in calcium polyphosphate bioceramics: An MRI-based characterization
Source abstract
Abstract
Degradable, bioceramic bone implants made of calcium polyphosphate (CPP) hold potential for controlled release of therapeutic agents in the treatment of localized bone disease. Magnetic resonance imaging techniques for non-invasively mapping fluid distribution, T(1) and T(2) relaxation times and the apparent diffusion coefficient were performed in conjunction with a drug elution protocol to resolve free and bound water components within the material microstructure in two CPP formulations (G1 and G2). The T(2) maps provided the most accurate estimates of free and bound water, and showed that G1 disks contained a detectable free water component at all times, with drug release dominated by a Fickian diffusion mechanism. Drug release from G2 disks was characterized by a combined diffusional/structural relaxation mechanism, which may be related to the gradual infiltration of a free water component associated with swelling and/or chemical degradation.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone health and treatments · Bone health and osteoporosis research · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (36)
Show source-provided references
1. Pharmaceutical applications of magnetic resonance imaging (MRI)10.1016/j.addr.2005.01.024 ↗
2. Magnetic resonance imaging of controlled release pharmaceutical dosage forms10.1016/S1461-5347(98)00008-X ↗
3. Porous calcium polyphosphate scaffolds for bone substitute applications – in vitro characterization10.1016/S0142-9612(00)00261-1 ↗
4. Fabrication and characterization of porous calcium polyphosphate scaffolds10.1007/s10853-006-5182-2 ↗
5. Hydrogelation of calcium metaphosphate glass10.1246/cl.2001.820 ↗
6. A compaction route for low temperature processing of porous calcium polyphosphate matrices
7. Vancomycin release behaviour from amorphous calcium polyphosphate matrices intended for osteomyelitis treatment10.1016/j.biomaterials.2005.05.072 ↗
8. Compaction strategies for modifying the drug delivery capabilities of gelled calcium polyphosphate matrices10.1016/j.actbio.2007.09.007 ↗
9. Gelled calcium polyphosphate matrices delay antibiotic release10.1177/154405910608500712 ↗
10. Bacterial osteomyelitis in adults: evolving considerations in diagnosis and treatment10.1016/S0002-9343(96)00260-4 ↗
11. Introduction to adult posttraumatic osteomyelitis of the tibia10.1097/00003086-199903000-00003 ↗
12. The effect of processing on the structural characteristics of vancomycin-loaded amorphous calcium phosphate matrices10.1016/j.biomaterials.2004.11.010 ↗
13. Treatment of osteomyelitis with a biodegradable antibiotic implant
14. Porous calcium polyphosphate scaffolds for bone substitute applications – in vivo studies10.1016/S0142-9612(01)00336-2 ↗
15. In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads10.1097/00003086-199205000-00037 ↗
16. Shi · 2004
17. Haake · 1999
18. Blümich · 2000
19. Structure and behaviour in hydrophilic matrix sustained release dosage forms: 2. NMR-imaging studies of dimensional changes in the gel layer and core of HPMC tablets undergoing hydration10.1016/0168-3659(94)00016-6 ↗
20. Structure and behavior in hydrophilic matrix sustained release dosage forms: 4. Studies of water mobility and diffusion coefficients in the gel layer of HPMC tablets using NMR imaging10.1023/A:1016084224084 ↗
21. Magnetic resonance imaging and relaxometry to study water transport mechanisms in a commercially available gastrointestinal therapeutic system (GITS) tablet10.1016/j.ijpharm.2010.06.047 ↗
22. The distribution of water in degrading polyglycolide. Part II: magnetic resonance imaging and drug release10.1023/A:1023223220409 ↗
23. Investigation of hydrogel formation from hydroxypropylmethylcellulose (HPMC) by NMR spectroscopy and NMR imaging techniques10.1021/ma970076o ↗
24. Polymer mobilization and drug release during tablet swelling – a 1H NMR and NMR microimaging study10.1016/j.jconrel.2007.07.007 ↗
25. Quantitative solid-state NMR imaging of synthetic calcium phosphate implants10.1002/(SICI)1522-2594(199906)41:6<1214::AID-MRM18>3.0.CO;2-H ↗
26. Measurement of fluid ingress into calcium polyphosphate bioceramics using nuclear magnetic resonance microscopy10.1016/j.ssnmr.2007.10.003 ↗
27. Self-diffusion and molecular mobility in PVA-based dissolution-controlled systems for drug delivery10.1016/S0730-725X(98)00021-6 ↗
28. Understanding radiation damping in a simple way10.1002/(SICI)1099-0534(1997)9:3<173::AID-CMR4>3.0.CO;2-W ↗
29. Calculation of the self-diffusion coefficient of water10.1007/BF00743446 ↗
30. Complex-forming adsorbents based on kaolinite, aluminium oxide and polyphosphates for the extraction and concentration of heavy metal ions from water solutions10.1016/S0169-1317(01)00061-8 ↗
31. Callaghan · 1993
32. McGown E. UV absorbance measurements in SpectraMax microplate spectrophotometers (MaxLine application note #32). .
33. Djogbenou · 2008
34. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices10.1016/0168-3659(87)90035-6 ↗
35. Mechanistic evaluation of binary effects of magnesium stearate and talc as dissolution retardants at 85% drug loading in an experimental extended-release formulation10.1021/js970052v ↗
36. Pulsed field gradient NMR study of the diffusion of H2O and polyethylene glycol polymers in the supramolecular structure of wet cotton10.1021/jp027703i ↗