Evaluation of a new press-fit in situ setting composite porous scaffold for cancellous bone repair: Towards a “surgeon-friendly” bone filler?
Source abstract
Abstract
In this study, a composite porous material obtained by coating a poly(ester urethane) foam with a calcium phosphate cement is proposed as novel cancellous bone filler with easy handling, in situ hardening and press-fitting properties. The coating can be applied to the foam in the surgical theater, allowing refinement of scaffold shape to the needs of the ongoing surgery. An innovative experiment was developed in order to determine the setting curve of the composite scaffold as well as the time of manipulation available to the surgeon without risk of material damage. This composite material is soft and can be press-fit in a cavity without damaging the scaffold in the first 5 min after coating application. The composite scaffold hardens quickly (22 min) and, once the cement has set, its compressive strength and fracture energy are increased by over an order of magnitude as compared to the initial poly(ester urethane) foam. This set of interesting properties makes calcium phosphate cement-coated elastomeric scaffolds a new promising strategy for cancellous bone filling.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Facial Trauma and Fracture Management · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (33)
Show source-provided references
1. Complete pelvic ring failure after posterior iliac bone graft harvesting10.1097/00007632-199910150-00006 ↗
2. Bone tissue engineering: state of the art and future trends10.1002/mabi.200400026 ↗
3. Polymer-bioceramic composites for tissue engineering scaffolds10.1007/s10853-008-2552-y ↗
4. Toughening of bio-ceramics scaffolds by polymer coating10.1016/j.jeurceramsoc.2006.10.016 ↗
5. Poly(d, l-lactic acid) coated 45S5 Bioglass®-based scaffolds: processing and characterization10.1002/jbm.a.30636 ↗
6. A three-phase, fully resorbable, polyester/calcium phosphate scaffold for bone tissue engineering: evolution of scaffold design10.1016/j.biomaterials.2006.11.025 ↗
7. Scaffolds in tissue engineering bone and cartilage10.1016/S0142-9612(00)00121-6 ↗
8. Factors affecting the structure and properties of an injectable self-setting calcium phosphate foam10.1002/jbm.a.30886 ↗
9. Fast setting calcium phosphate–chitosan scaffold: mechanical properties and biocompatibility10.1016/j.biomaterials.2004.04.043 ↗
10. Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles10.1016/j.biomaterials.2006.05.022 ↗
11. Effects of fibre reinforcement on the mechanical properties of brushite cement10.1016/j.actbio.2005.09.001 ↗
12. Self-hardening calcium phosphate cement-mesh composite: Reinforcement, macropores, and cell response10.1002/jbm.a.20124 ↗
13. Micro-architecture of calcium phosphate granules and fibrin glue composites for bone tissue engineering10.1016/j.biomaterials.2005.11.038 ↗
14. Preparation, degradation, and calcification of biodegradable polyurethane foams for bone graft substitutes10.1002/jbm.a.10148 ↗
15. Vertebroplasty and kyphoplasty: filler materials10.1016/j.spinee.2005.02.020 ↗
16. Properties of osteoconductive biomaterials: calcium phosphates10.1097/00003086-200202000-00009 ↗
17. Biomechanical and histological evaluation of a calcium phosphate cement10.2106/00004623-199808000-00004 ↗
18. Calcium phosphate cement: review of mechanical and biological properties10.1111/j.1532-849X.2006.00129.x ↗
19. Farsenol-modified biodegradable polyurethanes for cartilage tissue engineering10.1002/jbm.a.32385 ↗
20. Setting reaction and hardening of an apatitic calcium phosphate cement10.1177/00220345970760041201 ↗
21. Rheological properties of an apatitic bone cement during initial setting10.1023/A:1012832325957 ↗
22. Effect of calcium carbonate on clinical compliance of apatitic calcium phosphate bone cement10.1002/(SICI)1097-4636(199724)38:4<356::AID-JBM8>3.0.CO;2-N ↗
23. Effect of micro- and macroporosity of bone substitutes on their mechanical properties and cellular response10.1023/B:JMSM.0000004006.90399.b4 ↗
24. Driessens · 1990
25. Biomechanics of cellular solids10.1016/j.jbiomech.2004.09.027 ↗
26. Density and architecture have greater effects on the toughness of trabecular bone than damage10.1016/j.bone.2008.12.030 ↗
27. Fracture of bone tissue: the “hows” and the “whys”10.1016/j.medengphy.2008.09.007 ↗
28. Structure–property relations and cytotoxicity of isosorbide-based biodegradable polyurethane scaffolds for tissue repair and regeneration10.1002/jbm.a.31481 ↗
29. Biodegradable polyurethane cancellous bone graft substitutes in the treatment of iliac crest defects10.1002/jbm.a.30834 ↗
30. Regeneration of bicortical defects in the iliac crest of estrogen-deficient sheep, using new biodegradable polyurethane bone graft substitutes10.1002/jbm.a.30669 ↗
31. In vivo biocompatibility and vascularization of biodegradable porous polyurethane scaffolds for tissue engineering10.1016/j.actbio.2009.02.006 ↗
32. Of the in vivo behavior of calcium phosphate cements and glasses as bone substitutes10.1016/j.actbio.2008.04.023 ↗
33. Resorption patterns of calcium-phosphate cements in bone10.1002/jbm.a.10593 ↗