Pt/TiO2 brain biocompatible nanoparticles: GBM treatment using the C6 model in Wistar rats
Source abstract
Abstract
In the present work we synthesized inorganic oxide nanoparticle carriers of platinum compounds and tested their therapeutic effect on animal models in which C6 glioma cells have been inoculated. TiO(2)-containing Pt(NH(3))(4)Cl(2) complexes were synthesized using sol-gel methods. The platinum species are chemically bonded to the TiO(2) carrier, as shown by Fourier transform infrared spectroscopy of probe molecules. Treatment with TiO(2)-Pt nanoparticles reduces tumour growth rate by up to 56%, showing that a synergistic effect exists between the TiO(2) carrier and the platinum drug.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Gold and Silver Nanoparticles Synthesis and Applications · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (30)
Show source-provided references
1. The present and future of nanotechnology in human health care10.1016/j.nano.2006.11.008 ↗
2. Nanotechnology platforms and physiological challenges for cancer therapeutics10.1016/j.nano.2006.12.002 ↗
3. Nanomedicine for implants: a review of studies and necessary experimental tools10.1016/j.biomaterials.2006.08.049 ↗
4. Brain tumor. Part 210.1056/NEJM199105303242205 ↗
5. Nanoparticles in cancer therapy and diagnosis10.1016/S0169-409X(02)00044-3 ↗
6. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting10.1016/S0065-2571(00)00013-3 ↗
7. Polyethylene glycol-diacyllipid micelles demonstrate increased accumulation in subcutaneous tumors in mice10.1023/A:1020488012264 ↗
8. Introduction of cisplatin into polymeric micelles10.1016/0168-3659(95)00165-4 ↗
9. A long-circulating copolymer in “passive targeting” to solid tumors10.3109/10611869708995848 ↗
10. Radozs M, Shen Y, Tang H. Nanoparticles for cytoplasmatic drug delivery to cancer cells. Patent WO 2007/001356 A2; January 2007.
11. Small-scale systems for in vivo drug delivery10.1038/nbt876 ↗
12. Growth of hydroxyapatite in a biocompatible mesoporous ordered silica10.1016/j.actbio.2005.12.006 ↗
13. A nanostructured titania bioceramic implantable device capable of drug delivery to the temporal lobe of the brain10.1016/j.colsurfa.2006.10.060 ↗
14. Blockage of angiotensin II type I receptor decreases the synthesis of growth factors and induces apoptosis in C6 cultured cells and C6 rat glioma10.1038/sj.bjc.6602483 ↗
15. Animal models for brain tumors: historical perspectives and futures directions10.3171/jns.1994.80.5.0865 ↗
16. Vibrational spectroscopy in the study of oxide and sulfide catalysts (excluding zeolites)
17. Infrared spectra of pyridinium salts in solution – I. The region of middle frequencies10.1016/0584-8539(82)80014-7 ↗
18. Use of pyridine CH(D) vibrations for the study of Lewis acidity of metal oxides10.1016/j.apcata.2006.03.011 ↗
19. Infrared studies of phase transitions in ferroelectric (C5H5NH)5Bi2Br1110.1016/j.vibspec.2005.07.003 ↗
20. Stretching vibrations of metal–ligand bonds in some platinum(II) and platinum(IV) complexes10.1007/BF00747043 ↗
21. Ship-in-bottle synthesis of palladium carbonyl complexes in NaY and NaX zeolites via the direct carbonylation of Pd(NH3)42+10.1016/S1387-1811(98)00310-2 ↗
22. Characterization of oxide surfaces and zeolites by carbon monoxide as an IR probe molecule10.1016/S0360-0564(02)47008-3 ↗
23. Surface chemistry of titania (anatase) and titania-supported catalysts10.1039/cs9962500061 ↗
24. FTIR study of low-temperature CO adsorption on pure and ammonia-precovered TiO2 anatase10.1021/la962104m ↗
25. Infrared emission and theoretical study of carbon monoxide adsorbed on alumina-supported Rh, Ir, and Pt catalysts10.1021/jp055745b ↗
26. NaX-encaged Pt carbonyls: reversible substitution of CO ligands by oxygen and ammonia. Evidence for a conservation of the polynuclear Pt skeleton10.1039/b002364g ↗
27. Anionic Pt carbonyl complexes in faujasites: matrix effect10.1021/jp960892i ↗
28. The chemistry of dinuclear analogues of the anticancer drug cisplatin. A DFT/CDM study10.1021/ja055741k ↗
29. Cell cycle checkpoints and their impact on anticancer therapeutics strategies10.1002/jcb.10699 ↗
30. Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer