Stable modification of poly(lactic acid) surface with neurite outgrowth-promoting peptides via hydrophobic collagen-like sequence
Source abstract
Abstract
Surface modification of poly(dl-lactic acid) (PLA) scaffolds has been performed using a biofunctional small peptide composed of collagen-like repetitive sequence and laminin-derived sequence (AG73-G(3)-(PPG)(5)) via hydrophobic interaction. The results of surface analysis suggest that AG73-G(3)-(PPG)(5) can be stably adsorbed onto PLA films via hydrophobic interaction at the (PPG)(5) region, and form an extracellular matrix-like layer composed of both structural and biosignalling sequences. In addition, neurite outgrowth of PC12 cells was observed on the AG73-G(3)-(PPG)(5)-adsorbed PLA film. These results indicate that AG73-G(3)-(PPG)(5) very effectively enhances neurite outgrowth activity on PLA films. The hydrophobic adsorption of collagen-like peptide bound to biosignalling molecules may be widely applied as a surface modifier of PLA films for tissue engineering.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: biodegradable polymer synthesis and properties · Collagen: Extraction and Characterization · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (34)
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