The potential role of strontium ranelate in treating particle-induced osteolysis
Source abstract
Abstract
Ultra high molecular weight polyethylene (UHMWPE) wear-particle-induced osteolysis is one of the major issues affecting the long-term survival of total joint prostheses. Currently, there are no effective therapeutic options to prevent osteolysis from occurring. The aim of this study was to evaluate the role of strontium ranelate (SR) in reducing the risk of particle-induced osteolysis. Forty-eight C57BL/6J ultra-high molecular weight polyethylene (UHMWPE) particle-induced murine calvarial osteolysis models were used. The mice were randomized into four groups as: sham (Group 1), UHMWPE particles (Group 2), and SR with UHMWPE particles (Group 3 and Group 4). Groups 1 to 3 were sacrificed at two weeks and group 4 was sacrificed at the fourth week. The skulls were then analyzed with a high-resolution micro-CT. Histological evaluation was then conducted and osteoclast numbers were analyzed for comparison. Based on the micro-CT, percentage bone volume and trabecular thickness were found to be significantly higher in Group 4 than in Group 2 (p<0.001). Osteoclast numbers in SR treated groups (Group 3 and Group 4) were reduced when compared to groups that did not receive SR treatment (Group 2). These results indicated that SR treatment helps to increase bone volume percentage and trabecular thickness and also suppresses osteoclast proliferation. It is suggested that oral SR treatment could serve as an alternative therapy for preventing particle-induced osteolysis.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Orthopaedic implants and arthroplasty · Bone fractures and treatments · Orthopedic Infections and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (46)
Show source-provided references
1. What’s new in orthopaedic research10.2106/00004623-200208000-00038 ↗
2. The role of macrophages in osteolysis of total joint replacement10.1016/j.biomaterials.2004.04.035 ↗
3. Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies10.1186/ar2170 ↗
4. The cellular and molecular biology of periprosthetic osteolysis10.1097/01.blo.0000238813.95035.1b ↗
5. Ten years’ experience with alendronate for osteoporosis in postmenopausal women10.1056/NEJMoa030897 ↗
6. Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT10.1002/jor.20620 ↗
7. Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis10.1007/s00011-010-0229-x ↗
8. The effects of local and systemic alendronate delivery on wear debris-induced osteolysis in vivo10.1002/jor.21062 ↗
9. Risk of osteomyelitis of the jaw induced by oral bisphosphonates in patients taking medications for osteoporosis: a hospital-based cohort study in Japan10.1016/j.bone.2012.08.115 ↗
10. Bisphosphonate therapy for osteoporosis: benefits, risks, and drug holiday10.1016/j.amjmed.2012.06.023 ↗
11. Mechanisms of action and therapeutic potential of strontium in bone10.1007/s002230010055 ↗
12. Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants10.1007/s00198-008-0815-8 ↗
13. Strontium ranelate prevents bone loss in a rat model of localized muscle paralysis10.1007/s10439-011-0406-2 ↗
14. Strontium ranelate decreases the incidence of new caudal vertebral fractures in a growing mouse model with spontaneous fractures by improving bone microarchitecture10.1007/s00198-010-1193-6 ↗
15. Strontium ranelate improves implant osseointegration10.1016/j.bone.2010.01.379 ↗
16. Cross-linked polyethylene and bisphosphonate therapy for osteolysis in total hip arthroplasty: a case report10.1177/230949900401200121 ↗
17. The effect of simvastatin on polyethylene particle-induced osteolysis10.1016/j.biomaterials.2004.09.043 ↗
18. Generation of narrowly distributed ultra-high-molecular-weight polyethylene particles by surface texturing techniques10.1002/jbm.b.10067 ↗
19. Characterization of submicron polyethylene wear debris from synovial-fluid samples of revised knee replacements using a light-scattering technique10.1002/(SICI)1097-4636(199607)31:3<355::AID-JBM9>3.0.CO;2-L ↗
20. Documents FG. Endotoxin Testing Recommendations for Single-Use Intraocular Ophthalmic Devices – Draft Guidance for Industry and Food and Drug Administration Staff. 2014, .
21. Decrease in particle-induced osteolysis in ovariectomized mice10.1002/jor.20987 ↗
22. Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model10.1002/jor.21002 ↗
23. A new insight into the dissociating effect of strontium on bone resorption and formation10.1016/j.actbio.2011.02.013 ↗
24. Strontium ranelate inhibits titanium-particle-induced osteolysis by restraining inflammatory osteoclastogenesis in vivo10.1016/j.actbio.2014.07.025 ↗
25. Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures10.1007/s00198-014-2791-5 ↗
26. Bisphosphonates in the treatment of osteoporosis10.1136/bmj.e3211 ↗
27. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: treatment of peripheral osteoporosis (TROPOS) study10.1210/jc.2004-1774 ↗
28. The decrease of particle-induced osteolysis after a single dose of bisphosphonate10.1016/j.biomaterials.2004.06.010 ↗
29. Effects of alendronate on particle-induced osteolysis in a rat model10.2106/00004623-200202000-00011 ↗
30. The John Charnley award. Inhibition of wear debris mediated osteolysis in a canine total hip arthroplasty model
31. Alendronate reduces periprosthetic bone loss after uncemented primary total hip arthroplasty: a prospective randomized study10.1359/jbmr.2001.16.11.2126 ↗
32. Strontium ranelate: a novel mode of action optimizing bone formation and resorption10.1007/s00198-004-1753-8 ↗
33. Strontium ranelate increases cartilage matrix formation10.1359/jbmr.2001.16.2.299 ↗
34. Strontium ranelate: a review of its use in the treatment of postmenopausal osteoporosis10.2165/10481900-000000000-00000 ↗
35. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis10.1056/NEJMoa022436 ↗
36. Inhibiting wear particles-induced osteolysis with naringin
37. N-acetyl-L-cysteine inhibits wear particle-induced prosthesis loosening10.1016/j.jss.2010.12.006 ↗
38. Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis10.1016/j.fct.2008.08.016 ↗
39. Inhibitory effects of luteolin on titanium particle-induced osteolysis in a mouse model10.1016/j.actbio.2012.05.002 ↗
40. The aqueous extract of Angelica sinensis, a popular Chinese herb, inhibits wear debris-induced inflammatory osteolysis in mice10.1016/j.jss.2011.08.011 ↗
41. Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice10.1053/meta.2002.33360 ↗
42. Strontium ranelate decreases the incidence of new caudal vertebral fractures in a growing mouse model with spontaneous fractures by improving bone microarchitecture10.1007/s00198-010-1193-6 ↗
43. Polyethylene particles of a ‘critical size’ are necessary for the induction of cytokines by macrophages in vitro10.1016/S0142-9612(98)00140-9 ↗
44. Osteolysis in failed total knee arthroplasty: a comparison of mobile-bearing and fixed-bearing knees10.2106/00004623-200212000-00015 ↗
45. Particle size and morphology of UHMWPE wear debris in failed total knee arthroplasties – a comparison between mobile bearing and fixed bearing knees10.1016/S0736-0266(02)00015-3 ↗
46. Wear-pattern analysis in retrieved tibial inserts of mobile-bearing and fixed-bearing total knee prostheses10.1302/0301-620X.92B4.22560 ↗